Abstract:
Abstract: A soluble fraction from rat brain neuronal perikarya was shown to contain both the specific and nonspecific forms of the enzyme acetylcholines‐terase (EC's 3.1.1.7. and 3.1.1.8., respectively). The ratio of the enzyme activities varied along the course of brain development: the nonspecific form being predominant from 1 to 15 days of age and the specific one showing the pattern of rising activity from day 15 onward. We suggest a possible relationship between this changing in cholinesterase activities and the establishment of synapses within the rat cerebral cortex. Copyright © 1982, Wiley Blackwell. All rights reserved
Registro:
Documento: |
Artículo
|
Título: | Postnatal Changes in the Activity Ratio of Specific and Nonspecific Cholinesterases from Neuronal Perikarya |
Autor: | Ochoa, E.L.M.; Brusco, A.; Idoyaga‐Vargas, V.P.; Carminatti, H. |
Filiación: | Institute de Biologiu Celular, Facultud de Medicinu, Buenos Aires, Argentina Instituto de Investigaciones Bioquimicas “Fundacion Cumpomur”, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina
|
Palabras clave: | Acetylcholinesterase; Neurons; Postnatal development; cholinesterase; animal experiment; central nervous system; in vitro study; nerve cell; nervous system; postnatal development; rat; Acetylcholinesterase; Animal; Brain; BW 284 C 51; Cholinesterases; Gallamine Triethiodide; Neurons; Osmolar Concentration; Rats; Subcellular Fractions; Support, Non-U.S. Gov't; Synapses |
Año: | 1982
|
Volumen: | 38
|
Número: | 5
|
Página de inicio: | 1236
|
Página de fin: | 1240
|
DOI: |
http://dx.doi.org/10.1111/j.1471-4159.1982.tb07896.x |
Título revista: | Journal of Neurochemistry
|
Título revista abreviado: | J. Neurochem.
|
ISSN: | 00223042
|
CAS: | cholinesterase, 9001-08-5; Acetylcholinesterase, EC 3.1.1.7; BW 284 C 51, 402-40-4; Cholinesterases, EC 3.1.1.8; Gallamine Triethiodide, 65-29-2
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223042_v38_n5_p1236_Ochoa |
Referencias:
- Appel, S.H., Day, E.D., Cellular and subcellular fractionation (1976) Busic Neurochrmistt‐y, pp. 34-59. , Siegel G. J., Albers R. W., Katzrnan R., Agranoff B. W., eds, pp., Little, Brown and Co, Boston
- Austin, L., Berry, W.K., Two selective inhibitors of cholinesterase (1953) Biochem. J., 54, pp. 695-698
- Changeux, J.P., Responses of acetylcholinesterase from Torpedo marmorata to salts and curararizing drugs (1966) Mol. Phurmucol., 2, pp. 369-392
- Davis, R., Koelle, G.B., Electron microscope localization of acetylcholinesterase and butirylcholinesterase in the superior cervical ganglion of the rat (1981) J. Cell Biol., 88, pp. 581-590
- Ellman, G.L., Courtney, K.D., Andres, V., Featherstone, K.M., A.ew and rapid colorimetric determination of acetyl‐cholinesterase activity (1961) Biochem. Pharmacol., 7, pp. 88-95
- Gomez, C.J., Pasquini, J.M., Soto, E.F., De Robertis, E., Binding of d‐[dimethyl‐ 14 C]tubocurarine acetylcho‐linesterase and proteolipids in subcellular membranes of cerebral cortex of the developing rat (1970) Journal of Neurochemistry, 17, pp. 1485-1492
- Hemminki, K., Hemminki, E., Giacobini, E., Activity on enzymes related to neurotransmission in neuronal and glial fractions (1973) Int. J. Neurosci., 5, pp. 87-90
- Idoyaga‐Vargas, V., Carminatti, H., Postnatal changes in dolichol pathway enzyme activities in cerebral cortex neurons (1982) Biochem. J., 202, pp. 87-95
- Idoyaga‐Vargas, V., Santiago, J.C., Petiet, P., Sellinger, O.Z., The early postnatal development of the neuronal lysosome (1972) Journal of Neurochemistry, 19, pp. 2533-2543
- Idoyaga‐Vargas, V., Belocopitow, E., Mentaberry, A., Carminatti, H., A.hosphatase acting on dolichyl phosphate in membranes from neuronal perikarya (1980) FEBS Lett., 122, pp. 63-66
- Johnson, D.E., Sellinger, O.Z., Protein synthesis in neurons and glial cells of the deveIoping rat brain: An in vivo study (1971) J. Neurochem., 18, pp. 1445-1460
- Knusel, A., Lehner, B., Kuenzle, C.C., Kistler, G.S., Isolation of neuronal nuclei from rat brain cortex (1973) J. Cell Biol., 59, pp. 762-765
- Koelle, G.B., Significance of acetylcholinesterase in central synaptic transmission (1969) Fed. Proc., 28, pp. 95-100
- Koelle, G.B., Koelle, W.A., Smyrl, E.G., Effects of inactivation of butirylcholinesterase on steady state and regenerating levels of ganglionic acetylcholinesterase (1977) J. Neurochem., 28, pp. 313-319
- Koelle, W.A., Smyrl, E.G., Kuch, G.A., Siddons, V.E., Koelle, G.B., Effects of protection of butiryl‐cholinesterase on regeneration of ganglionic acetylcholin‐esterase (1977) J. Neurochem., 28, pp. 307-312
- Kohl, H.H., Sellinger, O.Z., Protein synthesis in neuronal perikarya isolated from cerebral cortex of the im‐mature rat (1971) J. Neurochem., 19, pp. 699-711
- Krnjevic, K., Silver, A., A histochemical study of cholinergic fibres in the cerebral cortex (1965) J Anat, 99, pp. 711-759
- Krnjevic, K., Silver, A., Acetylcholinesterase in the developing fore brain (1966) J. Anfit., 100, pp. 63-89
- Lapetina, E.G., Soto, E.F., De Robertis, E., Gangliosides and acetylcholinesterase in isolated membranes of the rat brain cortex (1967) Biochim. Biophy. Acta, 135, pp. 33-43
- Lehmann, J., Fibiger, H.C., Minireview acetylcholinesterase and the cholinergic neuron (1979) Life Sci., 25, pp. 1939-1947
- Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
- Nachmansohn, D., Rothenberg, M.A., Studies on cholinesterase I. On the specificity of the enzyme in nerve tissue (1945) J. Biol. Chem., 158, pp. 653-666
- Ochoa, E.L.M., Discopyge tschudi electric organ acetylcholinesterase: Extraction and demonstration of multiple molecular forms (1980) Comp. Biochem. Physioi., 66, pp. 99-103
- Potter, L.T., Acetylcholine, choline acetyl transferase and acetylcholinesterase (1970) Handbook of Neurochemistry, 4, pp. 263-284. , Lajtha A., eds, pp., Plenum Press, New York
- Rieger, F., Vigny, M., Solubilization and physicochemical characterization of rat brain acetylcholinesterase: development and maturation of its molecular forms (1976) J. Neurochem., 27, pp. 121-129
- Rodriguez de Lores Arnaiz, G., Subcellular localization of cholinesterase in brain (1964) J. Hisrochem. Cytochem., 12, pp. 696-699
- Rodriguez de Lores Arnaiz, G., De Robertis, E., Properties of the isolated nerve endings (1972) Curr. Top. Memhr. Trunsp., 3, pp. 237-271
- Rosenberry, T., Acetylcholinesterase (1975) Advances in Enzymology, 43, pp. 103-218. , Meister A., eds, pp., Wiley, New York
- Sellinger, O.Z., Azcurra, J.M., Johnson, D.E., Ohlsson, W.G., Lodin, Z., Independence of protein synthesis and drug uptake in nerve cell bodies and dial cells isolated by a new technique (1971) Nature, 230, pp. 253-256
- Vigny, M., Gisiger, V., Massoulie, J., Nonspecific cholinesterase and acetylcholinesterase in rat tissues, molecular forms, structural and catalytic properties and significance of the two enzyme systems (1978) Proc. Natl. Acud. Sci. USA., 5, pp. 2588-2592
Citas:
---------- APA ----------
Ochoa, E.L.M., Brusco, A., Idoyaga‐Vargas, V.P. & Carminatti, H.
(1982)
. Postnatal Changes in the Activity Ratio of Specific and Nonspecific Cholinesterases from Neuronal Perikarya. Journal of Neurochemistry, 38(5), 1236-1240.
http://dx.doi.org/10.1111/j.1471-4159.1982.tb07896.x---------- CHICAGO ----------
Ochoa, E.L.M., Brusco, A., Idoyaga‐Vargas, V.P., Carminatti, H.
"Postnatal Changes in the Activity Ratio of Specific and Nonspecific Cholinesterases from Neuronal Perikarya"
. Journal of Neurochemistry 38, no. 5
(1982) : 1236-1240.
http://dx.doi.org/10.1111/j.1471-4159.1982.tb07896.x---------- MLA ----------
Ochoa, E.L.M., Brusco, A., Idoyaga‐Vargas, V.P., Carminatti, H.
"Postnatal Changes in the Activity Ratio of Specific and Nonspecific Cholinesterases from Neuronal Perikarya"
. Journal of Neurochemistry, vol. 38, no. 5, 1982, pp. 1236-1240.
http://dx.doi.org/10.1111/j.1471-4159.1982.tb07896.x---------- VANCOUVER ----------
Ochoa, E.L.M., Brusco, A., Idoyaga‐Vargas, V.P., Carminatti, H. Postnatal Changes in the Activity Ratio of Specific and Nonspecific Cholinesterases from Neuronal Perikarya. J. Neurochem. 1982;38(5):1236-1240.
http://dx.doi.org/10.1111/j.1471-4159.1982.tb07896.x