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Abstract:

Pregabalin (PGB) is extensively prescribed to treat neurological and neuropsychiatrical conditions such as neuropathic pain, anxiety disorders, and epilepsy. Although PGB is known to bind selectively to the α2δ subunit of voltage-gated calcium channels, there is little understanding about how it exerts its therapeutic effects. In this article, we analyzed the effects of an in vivo chronic treatment with PGB over the physiology of dentate gyrus granule cells (DGGCs) using ex vivo electrophysiological and morphological analysis in adult mice. We found that PGB decreases neuronal excitability of DGGCs. In addition, PGB accelerates maturation of adult-born DGGCs, an effect that would modify dentate gyrus plasticity. Together, these findings suggest that PGB reduces activity in the dentate gyrus and modulates overall network plasticity, which might contribute to its therapeutic effects. (Figure presented.). Cover Image for this issue: doi: 10.1111/jnc.13783. © 2016 International Society for Neurochemistry

Registro:

Documento: Artículo
Título:Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells
Autor:Lempel, A.A.; Coll, L.; Schinder, A.F.; Uchitel, O.D.; Piriz, J.
Filiación:Instituto de Fisiología Biología Molecular y Neurociencias (IFIBYNE, UBA-CONICET), Buenos Aires, Argentina
Fundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA – CONICET), Buenos Aires, Argentina
Instituto de Fisiología y Biofísica “Houssay” (IFIBIO “Houssay”, UBA-CONICET), Buenos Aires, Argentina
Palabras clave:dentate gyrus; Gabapentin; neurogenesis; Pregabalin; pregabalin; retrovirus vector; 4 aminobutyric acid; calcium channel; pregabalin; adult; animal cell; animal experiment; animal tissue; Article; brain electrophysiology; brain function; cell maturation; controlled study; dentate hilus; drug mechanism; ex vivo study; excitatory postsynaptic potential; granule cell; in vivo study; male; mouse; nerve cell excitability; nerve cell plasticity; neuroanatomy; neuromodulation; newborn; nonhuman; priority journal; synaptic transmission; whole cell patch clamp; aging; animal; C57BL mouse; cell granule; dentate gyrus; drug effects; epilepsy; metabolism; nerve cell; neuralgia; physiology; Aging; Animals; Calcium Channels; Cytoplasmic Granules; Dentate Gyrus; Epilepsy; gamma-Aminobutyric Acid; Mice, Inbred C57BL; Neuralgia; Neurons; Pregabalin
Año:2017
Volumen:140
Número:2
Página de inicio:257
Página de fin:267
DOI: http://dx.doi.org/10.1111/jnc.13740
Título revista:Journal of Neurochemistry
Título revista abreviado:J. Neurochem.
ISSN:00223042
CODEN:JONRA
CAS:pregabalin, 148553-50-8; 4 aminobutyric acid, 28805-76-7, 56-12-2; Calcium Channels; gamma-Aminobutyric Acid; Pregabalin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223042_v140_n2_p257_Lempel

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Citas:

---------- APA ----------
Lempel, A.A., Coll, L., Schinder, A.F., Uchitel, O.D. & Piriz, J. (2017) . Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells. Journal of Neurochemistry, 140(2), 257-267.
http://dx.doi.org/10.1111/jnc.13740
---------- CHICAGO ----------
Lempel, A.A., Coll, L., Schinder, A.F., Uchitel, O.D., Piriz, J. "Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells" . Journal of Neurochemistry 140, no. 2 (2017) : 257-267.
http://dx.doi.org/10.1111/jnc.13740
---------- MLA ----------
Lempel, A.A., Coll, L., Schinder, A.F., Uchitel, O.D., Piriz, J. "Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells" . Journal of Neurochemistry, vol. 140, no. 2, 2017, pp. 257-267.
http://dx.doi.org/10.1111/jnc.13740
---------- VANCOUVER ----------
Lempel, A.A., Coll, L., Schinder, A.F., Uchitel, O.D., Piriz, J. Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells. J. Neurochem. 2017;140(2):257-267.
http://dx.doi.org/10.1111/jnc.13740