Artículo

Baidanoff, F.M.; Plano, S.A.; Doctorovich, F.; Suárez, S.A.; Golombek, D.A.; Chiesa, J.J. "N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms" (2014) Journal of Neurochemistry. 129(1):60-71
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Abstract:

Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a twofold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of FBJ murine osteosarcoma viral oncogene and period1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-h delay). Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. © 2013 International Society for Neurochemistry.

Registro:

Documento: Artículo
Título:N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
Autor:Baidanoff, F.M.; Plano, S.A.; Doctorovich, F.; Suárez, S.A.; Golombek, D.A.; Chiesa, J.J.
Filiación:Laboratorio de Cronobiología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes/CONICET, Bernal, Argentina
Departamento de Quimica Inorganica, Analitica y Quimica Fisica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:circadian; jet lag; N-nitrosomelatonin; nitric oxide; suprachiasmatic nucleus; melatonin; melatonin derivative; n nitrosomelatonin; nitrate; nitric oxide; nitric oxide synthase; nitrite; PER1 protein; protein c fos; unclassified drug; adult; animal experiment; animal model; animal tissue; article; chronobiology; circadian rhythm; controlled study; drug mechanism; immunoreactivity; in vivo study; jet lag; light dark cycle; locomotion; male; nonhuman; photic synchronization; photoperiodicity; priority journal; suprachiasmatic nucleus; Cricetinae; Mammalia; Murinae; circadian; jet lag; N-nitrosomelatonin; nitric oxide; suprachiasmatic nucleus; Animals; Circadian Rhythm; Cricetinae; Male; Melatonin; Mesocricetus; Motor Activity; Nitroso Compounds; Photic Stimulation; Photoperiod; Suprachiasmatic Nucleus
Año:2014
Volumen:129
Número:1
Página de inicio:60
Página de fin:71
DOI: http://dx.doi.org/10.1111/jnc.12613
Título revista:Journal of Neurochemistry
Título revista abreviado:J. Neurochem.
ISSN:00223042
CODEN:JONRA
CAS:melatonin, 73-31-4; nitrate, 14797-55-8; nitric oxide, 10102-43-9; nitric oxide synthase, 125978-95-2; nitrite, 14797-65-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223042_v129_n1_p60_Baidanoff

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Citas:

---------- APA ----------
Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A. & Chiesa, J.J. (2014) . N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms. Journal of Neurochemistry, 129(1), 60-71.
http://dx.doi.org/10.1111/jnc.12613
---------- CHICAGO ----------
Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A., Chiesa, J.J. "N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms" . Journal of Neurochemistry 129, no. 1 (2014) : 60-71.
http://dx.doi.org/10.1111/jnc.12613
---------- MLA ----------
Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A., Chiesa, J.J. "N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms" . Journal of Neurochemistry, vol. 129, no. 1, 2014, pp. 60-71.
http://dx.doi.org/10.1111/jnc.12613
---------- VANCOUVER ----------
Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A., Chiesa, J.J. N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms. J. Neurochem. 2014;129(1):60-71.
http://dx.doi.org/10.1111/jnc.12613