Abstract:
Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a twofold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of FBJ murine osteosarcoma viral oncogene and period1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-h delay). Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. © 2013 International Society for Neurochemistry.
Registro:
Documento: |
Artículo
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Título: | N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms |
Autor: | Baidanoff, F.M.; Plano, S.A.; Doctorovich, F.; Suárez, S.A.; Golombek, D.A.; Chiesa, J.J. |
Filiación: | Laboratorio de Cronobiología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes/CONICET, Bernal, Argentina Departamento de Quimica Inorganica, Analitica y Quimica Fisica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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Palabras clave: | circadian; jet lag; N-nitrosomelatonin; nitric oxide; suprachiasmatic nucleus; melatonin; melatonin derivative; n nitrosomelatonin; nitrate; nitric oxide; nitric oxide synthase; nitrite; PER1 protein; protein c fos; unclassified drug; adult; animal experiment; animal model; animal tissue; article; chronobiology; circadian rhythm; controlled study; drug mechanism; immunoreactivity; in vivo study; jet lag; light dark cycle; locomotion; male; nonhuman; photic synchronization; photoperiodicity; priority journal; suprachiasmatic nucleus; Cricetinae; Mammalia; Murinae; circadian; jet lag; N-nitrosomelatonin; nitric oxide; suprachiasmatic nucleus; Animals; Circadian Rhythm; Cricetinae; Male; Melatonin; Mesocricetus; Motor Activity; Nitroso Compounds; Photic Stimulation; Photoperiod; Suprachiasmatic Nucleus |
Año: | 2014
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Volumen: | 129
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Número: | 1
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Página de inicio: | 60
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Página de fin: | 71
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DOI: |
http://dx.doi.org/10.1111/jnc.12613 |
Título revista: | Journal of Neurochemistry
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Título revista abreviado: | J. Neurochem.
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ISSN: | 00223042
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CODEN: | JONRA
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CAS: | melatonin, 73-31-4; nitrate, 14797-55-8; nitric oxide, 10102-43-9; nitric oxide synthase, 125978-95-2; nitrite, 14797-65-0
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223042_v129_n1_p60_Baidanoff |
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Citas:
---------- APA ----------
Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A. & Chiesa, J.J.
(2014)
. N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms. Journal of Neurochemistry, 129(1), 60-71.
http://dx.doi.org/10.1111/jnc.12613---------- CHICAGO ----------
Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A., Chiesa, J.J.
"N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms"
. Journal of Neurochemistry 129, no. 1
(2014) : 60-71.
http://dx.doi.org/10.1111/jnc.12613---------- MLA ----------
Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A., Chiesa, J.J.
"N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms"
. Journal of Neurochemistry, vol. 129, no. 1, 2014, pp. 60-71.
http://dx.doi.org/10.1111/jnc.12613---------- VANCOUVER ----------
Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A., Chiesa, J.J. N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms. J. Neurochem. 2014;129(1):60-71.
http://dx.doi.org/10.1111/jnc.12613