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Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response. © 2012 The Authors. Journal of Neurochemistry © 2012 International Society for Neurochemistry.


Documento: Artículo
Título:Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
Autor:Galigniana, N.M.; Ballmer, L.T.; Toneatto, J.; Erlejman, A.G.; Lagadari, M.; Galigniana, M.D.
Filiación:Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina
Departamento de Química Biolõgica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:depression; glucocorticoid receptor; Hsp90; Hypothalamic- Pituitary-Adrenal axis; immunophilin; tetratricopeptide repeat domain; chaperone; fk 506 binding protein; fk 506 binding protein 51; glucocorticoid; glucocorticoid receptor; heat shock protein 90; immunophilin; mineralocorticoid receptor; peptidylprolyl isomerase; steroid receptor; unclassified drug; anxiety disorder; Cushing disease; depression; disease association; disease course; drug resistance; genetic association; genetic variability; hormone response; human; Human immunodeficiency virus infection; hypothalamus hypophysis adrenal system; immune response; mental stress; mood disorder; nonhuman; posttraumatic stress disorder; priority journal; protein binding; protein defect; protein domain; protein expression; protein function; protein polymorphism; protein structure; protein targeting; regulatory mechanism; review; risk factor; signal transduction; stress; Animals; Anxiety Disorders; Glucocorticoids; Humans; Mood Disorders; Peptidylprolyl Isomerase; Receptors, Steroid; Stress Disorders, Post-Traumatic; Tacrolimus Binding Proteins
Página de inicio:4
Página de fin:18
Título revista:Journal of Neurochemistry
Título revista abreviado:J. Neurochem.
CAS:peptidylprolyl isomerase, 95076-93-0; Glucocorticoids; Peptidylprolyl Isomerase,; Receptors, Steroid; Tacrolimus Binding Proteins, 5.2.1.-; tacrolimus binding protein 5,


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---------- APA ----------
Galigniana, N.M., Ballmer, L.T., Toneatto, J., Erlejman, A.G., Lagadari, M. & Galigniana, M.D. (2012) . Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51. Journal of Neurochemistry, 122(1), 4-18.
---------- CHICAGO ----------
Galigniana, N.M., Ballmer, L.T., Toneatto, J., Erlejman, A.G., Lagadari, M., Galigniana, M.D. "Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51" . Journal of Neurochemistry 122, no. 1 (2012) : 4-18.
---------- MLA ----------
Galigniana, N.M., Ballmer, L.T., Toneatto, J., Erlejman, A.G., Lagadari, M., Galigniana, M.D. "Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51" . Journal of Neurochemistry, vol. 122, no. 1, 2012, pp. 4-18.
---------- VANCOUVER ----------
Galigniana, N.M., Ballmer, L.T., Toneatto, J., Erlejman, A.G., Lagadari, M., Galigniana, M.D. Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51. J. Neurochem. 2012;122(1):4-18.