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Abstract:

Disinhibition syndromes, ranging from mildly inappropriate social behavior to full blown mania, may result from lesions to specific brain areas. Several studies in patients with closed head injuries, brain tumors, stroke lesions, and focal epilepsy have demonstrated a significant association between disinhibition syndromes and dysfunction of orbitofrontal and basotemporal cortices of the right hemisphere. Based on the phylogenetic origin of these cortical areas and their main connections with dorsal regions related to visuospatial functions, somatosensation, and spatial memory, the orbitofrontal and basotemporal cortices may selectively inhibit or release motor, instinctive, affective, and intellectual behaviors elaborated in the dorsal cortex. Thus, dysfunction of these heteromodal ventral brain areas may result in disinhibited behaviors.

Registro:

Documento: Artículo
Título:Mechanism of disinhibition after brain lesions
Autor:Starkstein, S.E.; Robinson, R.G.
Filiación:Department of Neuropsychiatry, Raul Carrea Inst. of Neurol. Res., Montaneses 2325, 1428 Buenos Aires, Argentina
Department of Psychiatry, University of Iowa, Iowa City, IA 52242, United States
Palabras clave:affect; brain cortex; brain injury; frontal lobe; human; inhibition kinetics; intelligence; mania; short survey; social behavior; temporal lobe; Adult; Animals; Bipolar Disorder; Brain Diseases; Brain Injuries; Cerebral Cortex; Delirium, Dementia, Amnestic, Cognitive Disorders; Female; Frontal Lobe; Functional Laterality; Humans; Inhibition (Psychology); Male; Neural Pathways; Risk Factors; Temporal Lobe
Año:1997
Volumen:185
Número:2
Página de inicio:108
Página de fin:114
DOI: http://dx.doi.org/10.1097/00005053-199702000-00007
Título revista:Journal of Nervous and Mental Disease
Título revista abreviado:J. NERV. MENT. DIS.
ISSN:00223018
CODEN:JNMDA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223018_v185_n2_p108_Starkstein

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Citas:

---------- APA ----------
Starkstein, S.E. & Robinson, R.G. (1997) . Mechanism of disinhibition after brain lesions. Journal of Nervous and Mental Disease, 185(2), 108-114.
http://dx.doi.org/10.1097/00005053-199702000-00007
---------- CHICAGO ----------
Starkstein, S.E., Robinson, R.G. "Mechanism of disinhibition after brain lesions" . Journal of Nervous and Mental Disease 185, no. 2 (1997) : 108-114.
http://dx.doi.org/10.1097/00005053-199702000-00007
---------- MLA ----------
Starkstein, S.E., Robinson, R.G. "Mechanism of disinhibition after brain lesions" . Journal of Nervous and Mental Disease, vol. 185, no. 2, 1997, pp. 108-114.
http://dx.doi.org/10.1097/00005053-199702000-00007
---------- VANCOUVER ----------
Starkstein, S.E., Robinson, R.G. Mechanism of disinhibition after brain lesions. J. NERV. MENT. DIS. 1997;185(2):108-114.
http://dx.doi.org/10.1097/00005053-199702000-00007