Abstract:
Disinhibition syndromes, ranging from mildly inappropriate social behavior to full blown mania, may result from lesions to specific brain areas. Several studies in patients with closed head injuries, brain tumors, stroke lesions, and focal epilepsy have demonstrated a significant association between disinhibition syndromes and dysfunction of orbitofrontal and basotemporal cortices of the right hemisphere. Based on the phylogenetic origin of these cortical areas and their main connections with dorsal regions related to visuospatial functions, somatosensation, and spatial memory, the orbitofrontal and basotemporal cortices may selectively inhibit or release motor, instinctive, affective, and intellectual behaviors elaborated in the dorsal cortex. Thus, dysfunction of these heteromodal ventral brain areas may result in disinhibited behaviors.
Registro:
Documento: |
Artículo
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Título: | Mechanism of disinhibition after brain lesions |
Autor: | Starkstein, S.E.; Robinson, R.G. |
Filiación: | Department of Neuropsychiatry, Raul Carrea Inst. of Neurol. Res., Montaneses 2325, 1428 Buenos Aires, Argentina Department of Psychiatry, University of Iowa, Iowa City, IA 52242, United States
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Palabras clave: | affect; brain cortex; brain injury; frontal lobe; human; inhibition kinetics; intelligence; mania; short survey; social behavior; temporal lobe; Adult; Animals; Bipolar Disorder; Brain Diseases; Brain Injuries; Cerebral Cortex; Delirium, Dementia, Amnestic, Cognitive Disorders; Female; Frontal Lobe; Functional Laterality; Humans; Inhibition (Psychology); Male; Neural Pathways; Risk Factors; Temporal Lobe |
Año: | 1997
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Volumen: | 185
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Número: | 2
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Página de inicio: | 108
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Página de fin: | 114
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DOI: |
http://dx.doi.org/10.1097/00005053-199702000-00007 |
Título revista: | Journal of Nervous and Mental Disease
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Título revista abreviado: | J. NERV. MENT. DIS.
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ISSN: | 00223018
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CODEN: | JNMDA
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223018_v185_n2_p108_Starkstein |
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Citas:
---------- APA ----------
Starkstein, S.E. & Robinson, R.G.
(1997)
. Mechanism of disinhibition after brain lesions. Journal of Nervous and Mental Disease, 185(2), 108-114.
http://dx.doi.org/10.1097/00005053-199702000-00007---------- CHICAGO ----------
Starkstein, S.E., Robinson, R.G.
"Mechanism of disinhibition after brain lesions"
. Journal of Nervous and Mental Disease 185, no. 2
(1997) : 108-114.
http://dx.doi.org/10.1097/00005053-199702000-00007---------- MLA ----------
Starkstein, S.E., Robinson, R.G.
"Mechanism of disinhibition after brain lesions"
. Journal of Nervous and Mental Disease, vol. 185, no. 2, 1997, pp. 108-114.
http://dx.doi.org/10.1097/00005053-199702000-00007---------- VANCOUVER ----------
Starkstein, S.E., Robinson, R.G. Mechanism of disinhibition after brain lesions. J. NERV. MENT. DIS. 1997;185(2):108-114.
http://dx.doi.org/10.1097/00005053-199702000-00007