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De Kowalewski, D.G.; Contreras, R.H.; De Los Santos, C. "13C- and 1H-NMR spectra of 2-pyridone derivatives" (1989) Journal of Molecular Structure. 213(C):201-212
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Abstract:

13C- and 1H-NMR spectroscopy was used to obtain njHH, nJCH and δC-13 for a series of substituted 2-hydroxypyridines (3-hydroxy; 4-hydroxy; 5-chloro; 3-methyl-5-chloro; 6-chloro; 6-amino; 6-hydroxy). It is shown that the additivity of δC-13 and 1JCH values provides a valuable criterion for differentiating between quinoidal and aromatic structures and in defining conformations. The first conclusion is based on the fact that for 3-substituted compounds there is accordance between experimental values and the additivity 1JCH and δC-13 values calculated for 2-pyridone. In the 6-substituted compounds there is marked deviation from additivity in 1JCH. On the other hand, it seems that the substituent effect on δC-13 in the hypothetical 2-hydroxypyridine and the real 2-pyridone are markedly different for C6, since there is no accordance between additivity and experimental values for the chemical shifts of this carbon. These conclusions are in agreement with results obtained from IR and pK studies and quantum-chemical calculations which indicate that a substituent in position 3 favours a pyridone structure, while a pyridinol structure is favoured when the substituent is at ring-position 6. © 1989.

Registro:

Documento: Artículo
Título:13C- and 1H-NMR spectra of 2-pyridone derivatives
Autor:De Kowalewski, D.G.; Contreras, R.H.; De Los Santos, C.
Filiación:Depto. de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Lab. de Fitoquímica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Año:1989
Volumen:213
Número:C
Página de inicio:201
Página de fin:212
DOI: http://dx.doi.org/10.1016/0022-2860(89)85120-8
Título revista:Journal of Molecular Structure
Título revista abreviado:J. Mol. Struct.
ISSN:00222860
CODEN:JMOSB
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222860_v213_nC_p201_DeKowalewski

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Citas:

---------- APA ----------
De Kowalewski, D.G., Contreras, R.H. & De Los Santos, C. (1989) . 13C- and 1H-NMR spectra of 2-pyridone derivatives. Journal of Molecular Structure, 213(C), 201-212.
http://dx.doi.org/10.1016/0022-2860(89)85120-8
---------- CHICAGO ----------
De Kowalewski, D.G., Contreras, R.H., De Los Santos, C. "13C- and 1H-NMR spectra of 2-pyridone derivatives" . Journal of Molecular Structure 213, no. C (1989) : 201-212.
http://dx.doi.org/10.1016/0022-2860(89)85120-8
---------- MLA ----------
De Kowalewski, D.G., Contreras, R.H., De Los Santos, C. "13C- and 1H-NMR spectra of 2-pyridone derivatives" . Journal of Molecular Structure, vol. 213, no. C, 1989, pp. 201-212.
http://dx.doi.org/10.1016/0022-2860(89)85120-8
---------- VANCOUVER ----------
De Kowalewski, D.G., Contreras, R.H., De Los Santos, C. 13C- and 1H-NMR spectra of 2-pyridone derivatives. J. Mol. Struct. 1989;213(C):201-212.
http://dx.doi.org/10.1016/0022-2860(89)85120-8