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Abstract:

A new charge transfer (CT) complex [(DAPH) + (DNB) - ] consisting of 2,6-diaminopyridine (DAP) as donor and 3,5-dinitrobenzoic acid (DNB-H) as acceptor, was synthesized and characterized by FTIR, 1 H and 13 C NMR, ESI mass spectroscopic and X-ray crystallographic techniques. The hydrogen bonding (N + -H⋯O - ) plays an important role to consolidate the cation and anion together. CT complex shows a considerable interaction with Calf thymus DNA. The CT complex was also tested for its antibacterial activity against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and two Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa strains by using Tetracycline as standard, and antifungal property against Aspergillus niger, Candida albicans, and Penicillium sp. by using Nystatin as standard. The results were compared with standard drugs and significant conclusions were obtained. A polymeric net work through H-bonding interactions between neighboring moieties was observed. This has been attributed to the formation of 1:1 type CT complex. © 2012 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies
Autor:Khan, I.M.; Ahmad, A.; Kumar, S.
Filiación:Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202 002, India
DQIAQF/INQUIMAE, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:2,6-Diaminopyridine; 3,5-Dinitrobenzoic acid; 13 C NMR; 1 H NMR; Charge transfer; DNA-binding; 2,6-Diaminopyridine; Anti-bacterial activity; Anti-fungal properties; Antimicrobial study; Aspergillus niger; Bacillus Subtilis; Calf thymus DNA; Candida albicans; Charge transfer complex; CT complex; DNA-binding; Esi mass; FTIR; Gram-negative bacteria; Gram-positive bacterium; H-bonding interaction; Penicillium sp; Pseudomonas aeruginosa; Spectroscopic characterization; Staphylococcus aureus; Structural investigation; Aspergillus; Charge transfer; Escherichia coli; Hydrogen bonds; Nuclear magnetic resonance spectroscopy; X ray crystallography; Bacteria; Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Negibacteria; Penicillium; Penicillium sp.; Posibacteria; Pseudomonas aeruginosa; Staphylococcus aureus
Año:2013
Volumen:1035
Página de inicio:38
Página de fin:45
DOI: http://dx.doi.org/10.1016/j.molstruc.2012.09.016
Título revista:Journal of Molecular Structure
Título revista abreviado:J. Mol. Struct.
ISSN:00222860
CODEN:JMOSB
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222860_v1035_n_p38_Khan

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Citas:

---------- APA ----------
Khan, I.M., Ahmad, A. & Kumar, S. (2013) . Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies. Journal of Molecular Structure, 1035, 38-45.
http://dx.doi.org/10.1016/j.molstruc.2012.09.016
---------- CHICAGO ----------
Khan, I.M., Ahmad, A., Kumar, S. "Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies" . Journal of Molecular Structure 1035 (2013) : 38-45.
http://dx.doi.org/10.1016/j.molstruc.2012.09.016
---------- MLA ----------
Khan, I.M., Ahmad, A., Kumar, S. "Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies" . Journal of Molecular Structure, vol. 1035, 2013, pp. 38-45.
http://dx.doi.org/10.1016/j.molstruc.2012.09.016
---------- VANCOUVER ----------
Khan, I.M., Ahmad, A., Kumar, S. Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies. J. Mol. Struct. 2013;1035:38-45.
http://dx.doi.org/10.1016/j.molstruc.2012.09.016