Artículo

Chemes, L.B.; Glavina, J.; Faivovich, J.; De Prat-Gay, G.; Sánchez, I.E. "Evolution of linear motifs within the papillomavirus E7 oncoprotein" (2012) Journal of Molecular Biology. 422(3):336-346
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Abstract:

Many protein functions can be traced to linear sequence motifs of less than five residues, which are often found within intrinsically disordered domains. In spite of their prevalence, their role in protein evolution is only beginning to be understood. The study of papillomaviruses has provided many insights on the evolution of protein structure and function. We have chosen the papillomavirus E7 oncoprotein as a model system for the evolution of functional linear motifs. The multiple functions of E7 proteins from paradigmatic papillomavirus types can be explained to a large extent in terms of five linear motifs within the intrinsically disordered N-terminal domain and two linear motifs within the globular homodimeric C-terminal domain. We examined the motif inventory of E7 proteins from over 200 known papillomavirus types and found that the motifs reported for paradigmatic papillomavirus types are absent from many uncharacterized E7 proteins. Several motif pairs occur more often than expected, suggesting that linear motifs may evolve and function in a cooperative manner. The E7 linear motifs have appeared or disappeared multiple times during papillomavirus evolution, confirming the evolutionary plasticity of short functional sequences. Four of the motifs appeared several times during papillomavirus evolution, providing direct evidence for convergent evolution. Interestingly, the evolution pattern of a motif is independent of its location in a globular or disordered domain. The correlation between the presence of some motifs and virus host specificity and tissue tropism suggests that linear motifs play a role in the adaptive evolution of papillomaviruses. © 2012 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Evolution of linear motifs within the papillomavirus E7 oncoprotein
Autor:Chemes, L.B.; Glavina, J.; Faivovich, J.; De Prat-Gay, G.; Sánchez, I.E.
Filiación:Protein Structure-Function and Engineering Laboratory, Fundación Instituto Leloir, IIBBA-CONICET, Patricias Argentinas 435 (1405), Buenos Aires, Argentina
Protein Physiology Laboratory, Departamento de Química Biológica, Ciudad Universitaria, Intendente Güiraldes 2160, 1428 Buenos Aires, Argentina
División Herpetología, Museo Argentino de Ciencias Naturales-CONICET, Ángel Gallardo 470, C1405DJR, Buenos Aires, Argentina
Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:adaptive evolution; convergent evolution; intrinsic disorder; sequence motif; virus; homodimer; protein E7; amino terminal sequence; article; carboxy terminal sequence; convergent evolution; enzyme phosphorylation; gene mutation; genetic variability; molecular evolution; nonhuman; Papilloma virus; papillomavirus infection; PDZ domain; phenotype; phylogeny; priority journal; protein domain; protein function; protein motif; viral tropism; virus cell interaction; virus virulence; Amino Acid Motifs; Amino Acid Sequence; Evolution, Molecular; Molecular Sequence Data; Papillomaviridae; Papillomavirus E7 Proteins; Protein Structure, Tertiary; Sequence Alignment; Papillomaviridae
Año:2012
Volumen:422
Número:3
Página de inicio:336
Página de fin:346
DOI: http://dx.doi.org/10.1016/j.jmb.2012.05.036
Título revista:Journal of Molecular Biology
Título revista abreviado:J. Mol. Biol.
ISSN:00222836
CODEN:JMOBA
CAS:Papillomavirus E7 Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222836_v422_n3_p336_Chemes

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Citas:

---------- APA ----------
Chemes, L.B., Glavina, J., Faivovich, J., De Prat-Gay, G. & Sánchez, I.E. (2012) . Evolution of linear motifs within the papillomavirus E7 oncoprotein. Journal of Molecular Biology, 422(3), 336-346.
http://dx.doi.org/10.1016/j.jmb.2012.05.036
---------- CHICAGO ----------
Chemes, L.B., Glavina, J., Faivovich, J., De Prat-Gay, G., Sánchez, I.E. "Evolution of linear motifs within the papillomavirus E7 oncoprotein" . Journal of Molecular Biology 422, no. 3 (2012) : 336-346.
http://dx.doi.org/10.1016/j.jmb.2012.05.036
---------- MLA ----------
Chemes, L.B., Glavina, J., Faivovich, J., De Prat-Gay, G., Sánchez, I.E. "Evolution of linear motifs within the papillomavirus E7 oncoprotein" . Journal of Molecular Biology, vol. 422, no. 3, 2012, pp. 336-346.
http://dx.doi.org/10.1016/j.jmb.2012.05.036
---------- VANCOUVER ----------
Chemes, L.B., Glavina, J., Faivovich, J., De Prat-Gay, G., Sánchez, I.E. Evolution of linear motifs within the papillomavirus E7 oncoprotein. J. Mol. Biol. 2012;422(3):336-346.
http://dx.doi.org/10.1016/j.jmb.2012.05.036