Artículo

Perez Di Giorgio, J.; Soto, G.; Alleva, K.; Jozefkowicz, C.; Amodeo, G.; Muschietti, J.P.; Ayub, N.D. "Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses" (2013) Journal of Membrane Biology:1-19
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Abstract:

Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence between eukaryotic AQPs and organismal trees identifying 32 orthologous clusters in plants and animals (Soto et al. Gene 503:165-176, 2012). In this article, we discuss in depth the methodological strength, the ability to predict functionality and the AQP community perception about the different paradigms of AQP evolution. Moreover, we show an updated review of AQPs transport functions in association with phylogenetic analyses. Finally, we discuss the possible effect of AQP data integration in the understanding of water and solute transport in eukaryotic cells. © 2013 Springer Science+Business Media New York.

Registro:

Documento: Artículo
Título:Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
Autor:Perez Di Giorgio, J.; Soto, G.; Alleva, K.; Jozefkowicz, C.; Amodeo, G.; Muschietti, J.P.; Ayub, N.D.
Filiación:Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Dr. Hector Torres (INGEBI-, Vuelta de Obligado 2490, Buenos Aires, C1428ADN, Argentina
Instituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA, CONICET-UBA), Intendente Güiraldes 2160, Ciudad Universitaria, Pabellón II, Buenos Aires, C1428EGA, Argentina
Departamento de Biodiversidad y Biologia Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, Ciudad Universitaria, Pabellón II, Buenos Aires, C1428EGA, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Avda. Rivadavia 1917, Buenos Aires, C1033AAJ, Argentina
Instituto de Genética Ewald A. Favret (CICVyA-INTA), De los reseros S/N, Castelar, Buenos Aires, CC25 (1712), Argentina
Idioma: Inglés
Palabras clave:Aquaporin; Evolution; Function; Integration
Año:2013
Página de inicio:1
Página de fin:19
DOI: http://dx.doi.org/10.1007/s00232-013-9618-8
Título revista:Journal of Membrane Biology
Título revista abreviado:J. Membr. Biol.
ISSN:00222631
CODEN:JMBBB
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222631_v_n_p1_PerezDiGiorgio

Citas:

---------- APA ----------
Perez Di Giorgio, J., Soto, G., Alleva, K., Jozefkowicz, C., Amodeo, G., Muschietti, J.P. & Ayub, N.D. (2013) . Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses. Journal of Membrane Biology, 1-19.
http://dx.doi.org/10.1007/s00232-013-9618-8
---------- CHICAGO ----------
Perez Di Giorgio, J., Soto, G., Alleva, K., Jozefkowicz, C., Amodeo, G., Muschietti, J.P., et al. "Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses" . Journal of Membrane Biology (2013) : 1-19.
http://dx.doi.org/10.1007/s00232-013-9618-8
---------- MLA ----------
Perez Di Giorgio, J., Soto, G., Alleva, K., Jozefkowicz, C., Amodeo, G., Muschietti, J.P., et al. "Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses" . Journal of Membrane Biology, 2013, pp. 1-19.
http://dx.doi.org/10.1007/s00232-013-9618-8
---------- VANCOUVER ----------
Perez Di Giorgio, J., Soto, G., Alleva, K., Jozefkowicz, C., Amodeo, G., Muschietti, J.P., et al. Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses. J. Membr. Biol. 2013:1-19.
http://dx.doi.org/10.1007/s00232-013-9618-8