Artículo

La versión final de este artículo es de uso interno. El editor solo permite incluir en el repositorio el artículo en su versión post-print. Por favor, si usted la posee enviela a
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Insects trigger a multifaceted innate immune response to fight microbial infections. We show that in the yellow mealworm, Tenebrio molitor, septic injuries induce the synthesis of N-β-alanyldopamine (NBAD), which is known as the main sclerotization precursor of insect brown cuticles. We demonstrate that NBAD synthase is induced in the epidermis of the mealworm and of the Medfly, Ceratitis capitata, by infection with Escherichia coli. Our results indicate that synthesis of NBAD seems to be a novel component of the overall innate immune response in insects. © 2007 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:The role of N-β-alanyldopamine synthase in the innate immune response of two insects
Autor:Schachter, J.; Pérez, M.M.; Quesada-Allué, L.A.
Filiación:Department of Biological Chemistry, FCEyN, University of Buenos Aires, Patricias Argentinas 435, Buenos Aires 1405, Argentina
Palabras clave:β-alanine; Ceratitis capitata; Insect immunity; N-β-alanyldopamine; Tenebrio molitor; catecholamine beta alanyl ligase; catecholamine-beta-alanyl ligase; dopamine; drug derivative; insect protein; ligase; N(beta) alanyldopamine; N(beta)-alanyldopamine; unclassified drug; beetle; enzyme activity; fly; immune response; larva; animal; article; enzyme induction; enzymology; epidermis; Escherichia coli; immunology; innate immunity; larva; Mediterranean fruit fly; metabolism; microbiology; physiology; Tenebrio; time; Animals; Ceratitis capitata; Dopamine; Enzyme Induction; Epidermis; Escherichia coli; Immunity, Natural; Insect Proteins; Larva; Ligases; Tenebrio; Time Factors; Ceratitis capitata; Escherichia coli; Hexapoda; Tenebrio; Tenebrio molitor
Año:2007
Volumen:53
Número:11
Página de inicio:1188
Página de fin:1197
DOI: http://dx.doi.org/10.1016/j.jinsphys.2007.06.010
Título revista:Journal of Insect Physiology
Título revista abreviado:J. Insect Physiol.
ISSN:00221910
CODEN:JIPHA
CAS:dopamine, 51-61-6, 62-31-7; ligase, 9080-13-1; Dopamine, 51-61-6; Insect Proteins; Ligases, 6.-; N(beta)-alanyldopamine, 54653-62-2; catecholamine-beta-alanyl ligase, 6.3.2.
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221910_v53_n11_p1188_Schachter

Referencias:

  • Agaisse, H., Petersen, U.M., Boutros, M., Mathey-Prevot, B., Perrimon, N., Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury (2003) Developmental Cell, 5, pp. 441-450
  • Ashida, M., Brey, P.T., Role of the integument in insect defense: pro-phenol oxidase cascade in the cuticular matrix (1995) Proceedings of the National Academy of Sciences of the United States of America, 92, pp. 10698-10702
  • Brennan, C.A., Delaney, J.R., Schneider, D.S., Anderson, K.V., Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body (2007) Current Biology, 17, pp. 67-72
  • Eriksson, B.M., Persson, B.A., Determination of catecholamines in rat heart tissue and plasma samples by liquid chromatography with electrochemical detection (1982) Journal of Chromatography, 228, pp. 143-154
  • Ferrandon, D., Imler, J.L., Hoffman, J.A., Sensing infection in Drosophila: toll and beyond (2004) Seminars in Immunology, 16, pp. 43-53
  • Hoffmann, J.A., The immune response of Drosophila (2003) Nature, 426, pp. 33-38
  • Hoffmann, J.A., Reichardt, J.M., Drosophila innate immunity: an evolutionary perspective (2002) Nature Immunology, 3, pp. 121-126
  • Hopkins, T.L., Kramer, K.J., Insect cuticle sclerotization (1992) Annual Review of Entomology, 37, pp. 273-302
  • Hopkins, T.L., Morgan, T.D., Aso, Y., Kramer, K.J., N-β-alanyldopamine: major role in insect cuticle tanning (1982) Science, 217, pp. 363-366
  • Hopkins, T.L., Starkey, S.R., Beckage, N.E., Tyrosine and catecholamine levels in the hemolymph of tobacco hornworm larvae, Manduca sexta, parasitized by the braconid wasp, Cotesia congregata, and in the developing parasitoids (1998) Archives of Insect Biochemistry and Physiology, 38, pp. 193-201
  • Kano, Y., Natori, S., Sarcophagine β-alanyl-l-tyrosine synthesis in the fat body of Sarcophaga peregrina larvae (1984) Journal of Biochemistry, 95, pp. 1041-1046
  • Kim, M.H., Joo, C.H., Cho, M.Y., Kwon, T.H., Lee, K.M., Natori, S., Lee, T.H., Lee, B.L., Bacterial-injection-induced syntheses of N-β-alanyldopamine and dopa decarboxilase in the hemolymph of coleopteran insect, Tenebrio molitor larvae (2000) European Journal of Biochemistry, 269, pp. 2599-2608
  • Kramer, K.J., Hopkins, Y.L., Tyrosine metabolism for insect cuticle tanning (1987) Archives of Insect Biochemistry and Physiology, 6, pp. 279-301
  • Leem, J.Y., Nishimura, C., Kurata, S., Shimada, I., Kobayashi, A., Natori, S., Purification and characterization of N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine, a novel antibacterial substance of Sarcophaga peregrina (flesh fly) (1996) Journal of Biological Chemistry, 271, pp. 13573-13577
  • Lemaitre, B., Reichardt, J.M., Hoffmann, J.A., Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms (1997) Proceedings of the National Academy of Sciences of the United States of America, 94, pp. 14614-14619
  • Meylaers, K., Cerstiaens, A., Vierstrate, E., Baderman, G., Michiels, W.D., De Loof, A., Schoofs, L., Antimicrobial compounds of low molecular mass are constitutively present in insects: characterisation of β-alanyl-tyrosine (2003) Current Pharmaceutical Design, 9, pp. 159-174
  • Nappi, A.J., Ottaviani, E., Cytotoxicity and cytotoxic molecules in invertebrates (2000) Bioessays, 22, pp. 469-480
  • Natori, S., Shiraishi, H., Horis, S., Kobayashi, A., The roles of Sarcophaga defense molecules in immunity and metamorphosis (1999) Developmental and Comparative Immunology, 23, pp. 317-328
  • Pérez, M., Wappner, P., Quesada-Allué, L.A., Catecholamine-β-alanyl ligase in the medfly Ceratitis capitata (2002) Insect Biochemistry and Molecular Biology, 32, pp. 617-625
  • Pérez, M., Schachter, J., Quesada-Allué, L.A., Constitutive activity of N-β-alanyl-catecholamine ligase in insect brain (2004) Neuroscience Letter, 368, pp. 186-191
  • Rabossi, A., Wappner, P., Quesada-Allué, L.A., Larva to pharate adult transformation in the medfly Ceratitis capitata (Wiedemann) (Diptera; Tephritidae) (1992) Canadian Entomologist, 124, pp. 1139-1147
  • Rabossi, A., Ación, L., Quesada-Allué, L.A., Metamorphosis-associated proteolysis in Ceratitis capitata (2000) Entomologia Experimentalis et Applicata, 94, pp. 57-65
  • Royet, J., Reichardt, J.M., Hoffmann, J.A., Sensing and signaling during infection in Drosophila (2005) Current Opinion in Immunology, 17, pp. 11-17
  • Tzou, P., De Gregorio, E., Lemaitre, B., How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions (2002) Current Opinion in Microbiology, 5, pp. 102-110
  • Wappner, P., Kramer, K.J., Hopkins, T.L., Cladera, J.L., Manso, F., Quesada-Allué, L.A., Role of catecholamines and β-alanine in puparial color of wild type and melanic mutants of the Mediterranean fruit fly (Ceratitis capitata) (1996) Journal of Insect Physiology, 42, pp. 455-461
  • Wappner, P., Kramer, K.J., Manso, F., Hopkins, T.L., Quesada-Allué, L.A., N-β-alanyldopamine metabolism in wild type and niger mutant strains of the Mediterranean fruit fly Ceratitis capitata (1996) Insect Biochemistry and Molecular Biology, 26, pp. 585-592
  • Willis, J.H., Morphogenetic action of insect hormones (1974) Annual Review of Entomology, 19, pp. 97-115
  • Yamasaki, N., Aso, Y., Tsukamoto, T., A convenient method for the preparation of N-β-alanyldopamine as substrate of phenol-oxidase (1990) Agricultural and Biological Chemistry, 54, pp. 833-836

Citas:

---------- APA ----------
Schachter, J., Pérez, M.M. & Quesada-Allué, L.A. (2007) . The role of N-β-alanyldopamine synthase in the innate immune response of two insects. Journal of Insect Physiology, 53(11), 1188-1197.
http://dx.doi.org/10.1016/j.jinsphys.2007.06.010
---------- CHICAGO ----------
Schachter, J., Pérez, M.M., Quesada-Allué, L.A. "The role of N-β-alanyldopamine synthase in the innate immune response of two insects" . Journal of Insect Physiology 53, no. 11 (2007) : 1188-1197.
http://dx.doi.org/10.1016/j.jinsphys.2007.06.010
---------- MLA ----------
Schachter, J., Pérez, M.M., Quesada-Allué, L.A. "The role of N-β-alanyldopamine synthase in the innate immune response of two insects" . Journal of Insect Physiology, vol. 53, no. 11, 2007, pp. 1188-1197.
http://dx.doi.org/10.1016/j.jinsphys.2007.06.010
---------- VANCOUVER ----------
Schachter, J., Pérez, M.M., Quesada-Allué, L.A. The role of N-β-alanyldopamine synthase in the innate immune response of two insects. J. Insect Physiol. 2007;53(11):1188-1197.
http://dx.doi.org/10.1016/j.jinsphys.2007.06.010