Artículo
Pasquinelli, V.; Townsend, J.C.; Jurado, J.O.; Alvarez, I.B.; Quiroga, M.F.; Barnes, P.F.; Samten, B.; García, V.E. "IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB" (2009) Journal of Infectious Diseases. 199(5):661-665
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Abstract:
Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-γ production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM+ T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-γ production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-γ production. Therefore, IL-17 and SLAM have opposing effects on IFN-γ production through CREB activation in persons with tuberculosis. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Registro:
| Documento: | Artículo |
| Título: | IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB |
| Autor: | Pasquinelli, V.; Townsend, J.C.; Jurado, J.O.; Alvarez, I.B.; Quiroga, M.F.; Barnes, P.F.; Samten, B.; García, V.E. |
| Filiación: | Department of Biological Chemistry, School of Sciences, University of Buenos Aires, Buenos Aires, Argentina Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX, United States Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX, United States Department of Medicine, University of Texas Health Center, Tyler, TX, United States Dept. of Biological Chemistry, School of Sciences, University of Buenos Aires, Intendente Guiraldes 2160, Capital Federal, 1428, Buenos Aires, Argentina |
| Palabras clave: | CD150 antigen; cyclic AMP responsive element binding protein; gamma interferon; interleukin 17; article; cell activation; clinical article; controlled study; human; human cell; peripheral blood mononuclear cell; priority journal; protein expression; protein phosphorylation; protein synthesis; T lymphocyte; tuberculosis; Antigens, CD; Cyclic AMP Response Element-Binding Protein; Gene Expression Regulation, Bacterial; Humans; Interferon-gamma; Interleukin-17; Phosphorylation; Receptors, Cell Surface; Tuberculosis |
| Año: | 2009 |
| Volumen: | 199 |
| Número: | 5 |
| Página de inicio: | 661 |
| Página de fin: | 665 |
| DOI: | http://dx.doi.org/10.1086/596742 |
| Título revista: | Journal of Infectious Diseases |
| Título revista abreviado: | J. Infect. Dis. |
| ISSN: | 00221899 |
| CODEN: | JIDIA |
| CAS: | cyclic AMP responsive element binding protein, 130428-87-4, 130939-96-7; gamma interferon, 82115-62-6; Antigens, CD; CD150 antigen, 169535-43-7; CREB1 protein, human; Cyclic AMP Response Element-Binding Protein; Interferon-gamma, 82115-62-6; Interleukin-17; Receptors, Cell Surface |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221899_v199_n5_p661_Pasquinelli |
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Citas:
---------- APA ----------
Pasquinelli, V., Townsend, J.C., Jurado, J.O., Alvarez, I.B., Quiroga, M.F., Barnes, P.F., Samten, B.,..., García, V.E. (2009) . IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB. Journal of Infectious Diseases, 199(5), 661-665.http://dx.doi.org/10.1086/596742
---------- CHICAGO ----------
Pasquinelli, V., Townsend, J.C., Jurado, J.O., Alvarez, I.B., Quiroga, M.F., Barnes, P.F., et al. "IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB" . Journal of Infectious Diseases 199, no. 5 (2009) : 661-665.http://dx.doi.org/10.1086/596742
---------- MLA ----------
Pasquinelli, V., Townsend, J.C., Jurado, J.O., Alvarez, I.B., Quiroga, M.F., Barnes, P.F., et al. "IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB" . Journal of Infectious Diseases, vol. 199, no. 5, 2009, pp. 661-665.http://dx.doi.org/10.1086/596742
---------- VANCOUVER ----------
Pasquinelli, V., Townsend, J.C., Jurado, J.O., Alvarez, I.B., Quiroga, M.F., Barnes, P.F., et al. IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB. J. Infect. Dis. 2009;199(5):661-665.http://dx.doi.org/10.1086/596742
