Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated. © 2013 HeteroCorporation.
Documento: | Artículo |
Título: | Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety |
Autor: | Barradas, J.S.; Errea, M.I.; Sepúlveda, C.; Damonte, E.B.; D'Accorso, N.B. |
Filiación: | CIHIDECAR-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Pabellón 2, Ciudad Universitaria 1428 Buenos Aires Argentina Departamento de Ingeniería Química Instituto Tecnológico de Buenos Aires Av. Eduardo Madero 399 1106 Buenos Aires Argentina IQUIBICEN-CONICET-Laboratorio de Virología- Departamento de Química biológica, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Pabellón 2, Ciudad Universitaria 1428 Buenos Aires Argentina |
Idioma: | Inglés |
Año: | 2013 |
DOI: | http://dx.doi.org/10.1002/jhet.1957 |
Título revista: | Journal of Heterocyclic Chemistry |
Título revista abreviado: | J. Heterocycl. Chem. |
ISSN: | 0022152X |
CODEN: | JHTCA |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022152X_v_n_p_Barradas |