Abstract:
Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated. © 2013 HeteroCorporation.
Registro:
Documento: |
Artículo
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Título: | Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety |
Autor: | Barradas, J.S.; Errea, M.I.; Sepúlveda, C.; Damonte, E.B.; D'Accorso, N.B. |
Filiación: | CIHIDECAR-CONICET, Departamento de Química Orgánica, Universidad de Buenos Aires, Pabellõn 2, 1428 Buenos Aires, Argentina Departamento de Ingeniería Química, Instituto Tecnolõgico de Buenos Aires, Av. Eduardo Madero 399, 1106 Buenos Aires, Argentina Departamento de Química Biolõgica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellõn 2, 1428 Buenos Aires, Argentina
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Año: | 2014
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Volumen: | 51
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Número: | 1
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Página de inicio: | 96
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Página de fin: | 100
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DOI: |
http://dx.doi.org/10.1002/jhet.1957 |
Título revista: | Journal of Heterocyclic Chemistry
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Título revista abreviado: | J. Heterocycl. Chem.
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ISSN: | 0022152X
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CODEN: | JHTCA
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022152X_v51_n1_p96_Barradas |
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Citas:
---------- APA ----------
Barradas, J.S., Errea, M.I., Sepúlveda, C., Damonte, E.B. & D'Accorso, N.B.
(2014)
. Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety. Journal of Heterocyclic Chemistry, 51(1), 96-100.
http://dx.doi.org/10.1002/jhet.1957---------- CHICAGO ----------
Barradas, J.S., Errea, M.I., Sepúlveda, C., Damonte, E.B., D'Accorso, N.B.
"Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety"
. Journal of Heterocyclic Chemistry 51, no. 1
(2014) : 96-100.
http://dx.doi.org/10.1002/jhet.1957---------- MLA ----------
Barradas, J.S., Errea, M.I., Sepúlveda, C., Damonte, E.B., D'Accorso, N.B.
"Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety"
. Journal of Heterocyclic Chemistry, vol. 51, no. 1, 2014, pp. 96-100.
http://dx.doi.org/10.1002/jhet.1957---------- VANCOUVER ----------
Barradas, J.S., Errea, M.I., Sepúlveda, C., Damonte, E.B., D'Accorso, N.B. Microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety. J. Heterocycl. Chem. 2014;51(1):96-100.
http://dx.doi.org/10.1002/jhet.1957