Artículo
Abstract:
The major natural reservoir of Junin virus, the aetiological agent of Argentine haemorrhagic fever, is the cricetid Calomys musculinus. Neonatal animals experimentally infected with Junin virus (XJCl3 strain) developed typical disease and approximately 80% of them died. Most survivors become persistently infected. Antigenically variant viruses were isolated from the blood and brain of infected cricetids during the acute and chronic stages of the disease. These variants could be distinguished from the parental strain by kinetic neutralization assays using polyclonal antibodies. Some biological properties were shared with the parental virus strain including its virulence for newborn C. musculinus. These variant viruses may play a major role in chronic disease since we have shown that a viral isolate from an infected brain was poorly neutralized by serum obtained from the same animal.
Registro:
| Documento: | Artículo |
| Título: | Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays |
| Autor: | Alche, L.E.; Coto, C.E. |
| Filiación: | Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Laboratorio de Virologia, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina |
| Palabras clave: | antigenic variation; Junin virus; nonhuman; Animalia; Argentina (fish); Calomys musculinus; Cricetinae; Junin virus |
| Año: | 1988 |
| Volumen: | 69 |
| Número: | 8 |
| Página de inicio: | 2123 |
| Página de fin: | 2127 |
| DOI: | http://dx.doi.org/10.1099/0022-1317-69-8-2123 |
| Título revista: | Journal of General Virology |
| Título revista abreviado: | J. GEN. VIROL. |
| ISSN: | 00221317 |
| CODEN: | JGVIA |
| PDF: | https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00221317_v69_n8_p2123_Alche.pdf |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221317_v69_n8_p2123_Alche |
Citas:
---------- APA ----------
Alche, L.E. & Coto, C.E. (1988) . Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays. Journal of General Virology, 69(8), 2123-2127.http://dx.doi.org/10.1099/0022-1317-69-8-2123
---------- CHICAGO ----------
Alche, L.E., Coto, C.E. "Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays" . Journal of General Virology 69, no. 8 (1988) : 2123-2127.http://dx.doi.org/10.1099/0022-1317-69-8-2123
---------- MLA ----------
Alche, L.E., Coto, C.E. "Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays" . Journal of General Virology, vol. 69, no. 8, 1988, pp. 2123-2127.http://dx.doi.org/10.1099/0022-1317-69-8-2123
---------- VANCOUVER ----------
Alche, L.E., Coto, C.E. Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays. J. GEN. VIROL. 1988;69(8):2123-2127.http://dx.doi.org/10.1099/0022-1317-69-8-2123
