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Díaz, M.E.; Miquet, J.G.; Rossi, S.P.; Irene, P.E.; Sotelo, A.I.; Frungieri, M.B.; Turyn, D.; González, L. "GH administration patterns differently regulate epidermal growth factor signaling" (2014) Journal of Endocrinology. 221(2):309-323
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Abstract:

GH administration protocols imply frequent s.c. injections, resulting in suboptimal compliance. Therefore, there is interest in developing delivery systems for sustained release of the hormone. However, GH has different actions depending on its continuous or pulsatile plasma concentration pattern. GH levels and circulating concentration patterns could be involved in the regulation of epidermal growth factor receptor (EGFR) expression in liver. Aberrant expression of this receptor and/or its hyperactivation has been associated with the pathogenesis of different types of carcinoma. Considering that one of the adverse effects associated with GH overexpression and chronic use of GH is the increased incidence of malignancies, the aim of this study was to analyze the effects of GH plasma concentration patterns on EGFR expression and signaling in livers of mice. For this purpose, GH was administered by s.c. daily injections to produce an intermittent plasma pattern or by osmotic pumps to provoke a continuously elevated GH concentration. Intermittent injections of GH induced upregulation of liver EGFR content, augmented the response to EGF, and the induction of proteins involved in promotion of cell proliferation in female mice. In contrast, continuous GH delivery in male mice was associated with diminished EGFR in liver and decreased EGF-induced signaling and expression of early genes. The results indicate that sustained delivery systems that allow continuous GH plasma patterns would be beneficial in terms of treatment safety with regard to the actions of GH on EGFR signaling and its promitogenic activity. © 2014 Society for Endocrinology.

Registro:

Documento: Artículo
Título:GH administration patterns differently regulate epidermal growth factor signaling
Autor:Díaz, M.E.; Miquet, J.G.; Rossi, S.P.; Irene, P.E.; Sotelo, A.I.; Frungieri, M.B.; Turyn, D.; González, L.
Filiación:Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Universidad de Buenos Aires, Junín 956, 1113 Ciudad de Buenos Aires, Argentina
Instituto de Biología y Medicina Experimental, CONICET, Vuelta de Obligado 2490, 1428 Ciudad de Buenos Aires, Argentina
Palabras clave:Epidermal growth factor; Growth hormone; Intracellular signaling; Liver; epidermal growth factor; growth hormone; EGFR protein, mouse; epidermal growth factor; epidermal growth factor receptor; growth hormone; adult; animal cell; animal experiment; animal model; article; cell activation; cell proliferation; controlled study; drug blood level; drug safety; female; gene expression; liver; male; mouse; nonhuman; osmotic pump; priority journal; protein content; protein expression; protein phosphorylation; signal transduction; upregulation; animal; blood; cell cycle; drug administration; drug effect; gene expression regulation; genetics; infusion pump; injection; intracellular signaling; metabolism; signal transduction; epidermal growth factor; growth hormone; intracellular signaling; liver; Animals; Cell Cycle; Drug Administration Schedule; Epidermal Growth Factor; Female; Gene Expression Regulation; Growth Hormone; Infusion Pumps; Injections; Male; Mice; Receptor, Epidermal Growth Factor; Signal Transduction
Año:2014
Volumen:221
Número:2
Página de inicio:309
Página de fin:323
DOI: http://dx.doi.org/10.1530/JOE-13-0447
Título revista:Journal of Endocrinology
Título revista abreviado:J. Endocrinol.
ISSN:00220795
CODEN:JOENA
CAS:epidermal growth factor, 62229-50-9; growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; epidermal growth factor receptor, 79079-06-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00220795_v221_n2_p309_Diaz

Referencias:

  • Biller, B.M., Ji, H.J., Ahn, H., Savoy, C., Siepl, E.C., Popovic, V., Coculescu, M., Cook, D.M., 12-Month effects of onceweekly sustained-release growth hormone treatment in adults with GH deficiency (2013) Pituitary, 16, pp. 311-318. , (doi:10.1007/s11102-012-0422-8)
  • Buettner, R., Mora, L.B., Jove, R., Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention (2002) Clinical Cancer Research, 8, pp. 945-954
  • Burgess, A.W., EGFR family: structure physiology signaling and therapeutic target (2008) Growth Factors, 26, pp. 263-274. , (doi:10.1080/08977190802312844)
  • Cavaggioni, A., Mucignat-Caretta, C., Major urinary proteins, a(2U-globulins and aphrodisin (2000) Biochimica et Biophysica Acta, 1482, pp. 218-228. , (doi:10.1016/S0167-4838(00)00149-7)
  • Clark, R.G., Robinson, I.C., Paradoxical growth-promoting effects induced by patterned infusions of somatostatin in female rats (1988) Endocrinology, 122, pp. 2675-2682. , (doi:10.1210/endo-122-6-2675)
  • Curran, T., Bravo, R., Müller, R., Transient induction of c-fos and c-myc in an immediate consequence of growth factor stimulation (1985) Cancer Surveys, 4, pp. 655-681
  • Díaz, M.E., González, L., Miquet, J.G., Martínez, C.S., Sotelo, A.I., Bartke, A., Turyn, D., Growth hormone modulation of EGF-induced PI3K-Akt pathway in mice liver (2012) Cellular Signalling, 24, pp. 514-523. , (doi:10.1016/j.cellsig.2011.10.001)
  • Ekberg, S., Carlsson, L., Carlsson, B., Billig, H., Jansson, J.O., Plasma growth hormone pattern regulates epidermal growth factor (EGF) receptor messenger ribonucleic acid levels and EGF binding in the rat liver (1989) Endocrinology, 125, pp. 2158-2166. , (doi:10.1210/endo-125-4-2158)
  • Fresno Vara, J.A., Casado, E., de Castro, J., Cejas, P., Belda-Iniesta, C., González-Barón, M., PI3K/Akt signalling pathway and cancer (2004) Cancer Treatment Reviews, 30, pp. 193-204. , (doi:10.1016/j.ctrv.2003.07.007)
  • Frungieri, M.B., Weidinger, S., Meineke, V., Kohn, F.M., Mayerhofer, A., Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARg: possible relevance to human fibrotic disorders (2002) PNAS, 99, pp. 15072-15077. , (doi:10.1073/pnas.232422999)
  • González, L., Díaz, M.E., Miquet, J.G., Sotelo, A.I., Fernández, D., Dominici, F.P., Bartke, A., Turyn, D., GH modulates hepatic epidermal growth factor signaling in the mouse (2010) Journal of Endocrinology, 204, pp. 299-309. , (doi:10.1677/JOE-09-0372)
  • Guren, T.K., Odegard, J., Abrahamsen, H., Thoresen, G.H., Susa, M., Andersson, Y., OØstby, E., Christoffersen, T., EGF receptor-mediated, c-Srcdependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes (2003) Journal of Cellular Physiology, 196, pp. 113-123. , (doi:10.1002/jcp.10282)
  • Henson, E.S., Gibson, S.B., Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy (2006) Cellular Signalling, 12, pp. 2089-2097. , (doi:10.1016/j.cellsig
  • Herrington, J., Carter-Su, C., Signaling pathways activated by the growth hormone receptor (2001) Trends in Endocrinology and Metabolism, 12, pp. 252-257. , (doi:10.1016/S1043-2760(01)00423-4)
  • Huang, Y., Kim, S.O., Jiang, J., Frank, S.J., Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling (2003) Journal of Biological Chemistry, 278, pp. 18902-18913. , (doi:10.1074/jbc.M300939200)
  • Huang, Y., Chang, Y., Wang, X., Jiang, J., Frank, S.J., Growth hormone alters epidermal growth factor receptor binding affinity via activation of extracellular signal-regulated kinases in 3T3-F442A cells (2004) Endocrinology, 145, pp. 3297-3306. , (doi:10.1210/en.2003-1658)
  • Huang, Y., Li, X., Jiang, J., Frank, S.J., Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells (2006) Oncogene, 25, pp. 7565-7576. , (doi:10.1038/sj.onc.1209740)
  • Ito, Y., Takeda, T., Sakon, M., Tsujimoto, M., Higashiyama, S., Noda, K., Miyoshi, E., Matsuura, N., Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma (2001) British Journal of Cancer, 84, pp. 1377-1383. , (doi:10.1054/bjoc.2000.1580)
  • Jaffe, C.A., Ocampo-Lim, B., Guo, W., Krueger, K., Sugahara, I., DeMott-Friberg, R., Bermann, M., Barkan, A.L., Regulatory mechanisms of growth hormone secretion are sexually dimorphic (1998) Journal of Clinical Investigation, 102, pp. 153-164. , (doi:10.1172/JCI2908)
  • Jaffe, C.A., Turgeon, D.K., Lown, K., Demott-Friberg, R., Watkins, P.B., Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans (2002) American Journal of Physiology. Endocrinology and Metabolism, 283, pp. 1008-1015. , (doi:10.1152/ajpendo.00513.2001)
  • Jansson, J.O., Edén, S., Isaksson, O., Sexual dimorphism in the control of growth hormone secretion (1985) Endocrine Reviews, 6, pp. 128-150. , (doi:10.1210/edrv-6-2-128)
  • Jansson, J.O., Ekberg, S., Hoath, S.B., Beamer, W.G., Frohman, L.A., Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice (1988) Journal of Clinical Investigation, 82, pp. 1871-1876. , (doi:10.1172/JCI113804)
  • Jenkins, P.J., Cancers associated with acromegaly (2006) Neuroendocrinology, 83, pp. 218-223. , (doi:10.1159/000095531)
  • Johansson, S., Husman, B., Norstedt, G., Andersson, G., Growth hormone regulates the rodent hepatic epidermal growth factor receptor at a pretranslational level (1989) Journal of Molecular Endocrinology, 3, pp. 113-120. , (doi:10.1677/jme.0.0030113)
  • Johansson, J.O., Oscarsson, J., Bjarnason, R., Bengtsson, B.A., Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GH-deficient adults: I. Effects on insulin-like growth factor-I (IGF-I), GH and IGF binding proteins, and glucose homeostasis (1996) Metabolism, 45, pp. 362-369. , (doi:10.1016/S0026-0495(96)90292-9)
  • Johnson, D., al-Shawi, R., Bishop, J.O., Sexual dimorphism and growth hormone induction of murine pheromone-binding proteins (1995) Journal of Molecular Endocrinology, 14, pp. 21-34. , (doi:10.1677/jme.0.0140021)
  • Karlsson, H., Gustafsson, J.A., Mode, A., Cis desensitizes GH induced Stat5 signaling in rat liver cells (1999) Molecular and Cellular Endocrinology, 154, pp. 37-43. , (doi:10.1016/S0303-7207(99)00101-X)
  • Kashimata, M., Hiramatsu, M., Minami, N., Differential secretory rhythm of growth hormone controls the number of hepatic epidermal growth factor receptors in the rat (1989) Journal of Endocrinology, 123, pp. 75-81. , (doi:10.1677/joe.0.1230075)
  • Kemp, S.F., Frindik, J.P., Emerging options in growth hormone therapy: an update (2011) Drug Design, Development and Therapy, 5, pp. 411-419. , (doi:10.2147/DDDT.S23140)
  • Kwak, H.H., Shim, W.S., Choi, M.K., Son, M.K., Kim, Y.J., Yang, H.C., Kim, T.H., Kang, S.H., Development of a sustained-release recombinant human growth hormone formulation (2009) Journal of Controlled Release, 137, pp. 160-165. , (doi:10.1016/j.jconrel.2009.03.014)
  • Laron, Z., Growth hormone therapy: emerging dilemmas (2011) Pediatric Endocrinology Reviews, 8, pp. 364-373
  • Laursen, T., Gravholt, C.H., Heickendorff, L., Drustrup, J., Kappelgaard, A.M., Jørgensen, J.O., Christiansen, J.S., Long-term effects of continuous subcutaneous infusion versus daily subcutaneous injections of growth hormone (GH) on the insulin-like growth factor system, insulin sensitivity, body composition, and bone and lipoproteinmetabolism in GH-deficient adults (2001) Journal of Clinical Endocrinology and Metabolism, 86, pp. 1222-1228. , (doi:10.1210/jcem.86.3.73)
  • Li, X., Huang, Y., Jiang, J., Frank, S.J., ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling (2008) Cellular Signalling, 20, pp. 2145-2155. , (doi:10.1016/j.cellsig.2008.08.006)
  • Lin, C.P., Liu, C.R., Lee, C.N., Chan, T.S., Liu, H.E., Targeting c-Myc as a novel approach for hepatocellular carcinoma (2010) World Journal of Hepatology, 2, pp. 16-20. , (doi:10.4254/wjh.v2.i1.16)
  • Liu, Z., Yan, R., Al-Salman, A., Shen, Y., Bu, Y., Ma, J., Luo, D.X., Wilber, A., Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells (2012) Biochemical Journal, 442, pp. 273-282. , (doi:10.1042/BJ20111322)
  • MacLeod, J.N., Pampori, N.A., Shapiro, B.H., Sex differences in the ultradian pattern of plasma growth hormone concentrations in mice (1991) Endocrinology, 131, pp. 395-399. , (doi:10.1677/joe.0.1310395)
  • Miquet, J.G., González, L., Matos, M.N., Hansen, C., Louis, A., Bartke, A., Turyn, D., Sotelo, A.I., Transgenic mice overexpressing GH exhibit hepatic upregulation of GH-signaling mediators involved in cell proliferation (2008) Journal of Endocrinology, 198, pp. 317-330. , (doi:10.1677/JOE-08-0002)
  • Miquet, J.G., Freund, T., Martinez, C.S., González, L., Diaz, M.E., Micucci, G.P., Zotta, E., Turyn, D., Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone (2013) Cell Cycle, 12, pp. 1042-1057. , (doi:10.4161/cc.24026)
  • Normanno, N., De Luca, A., Bianco, C., Strizzi, L., Mancino, M., Maiello, M.R., Carotenuto, A., Salomon, D.S., Epidermal growth factor receptor (EGFR) signaling in cancer (2006) Gene, 366, pp. 2-16. , (doi:10.1016/j.gene.2005.10.018)
  • Norstedt, G., Palmiter, R., Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver (1984) Cell, 36, pp. 805-812. , (doi:10.1016/0092-8674(84)90030-8)
  • Osaki, M., Oshimura, M., Ito, H., PI3K-Akt pathway: its functions and alterations in human cancer (2004) Apoptosis, 9, pp. 667-676. , (doi:10.1023/B:APPT.0000045801.15585.dd)
  • Park, M.R., Seo, B.B., Song, S.C., Dual ionic interaction system based on polyelectrolyte complex and ionic, injectable, and thermosensitive hydrogel for sustained release of human growth hormone (2013) Biomaterials, 34, pp. 1327-1336. , (doi:10.1016/j.biomaterials.2012.10.033)
  • Péter, F., Bidlingmaier, M., Savoy, C., Ji, H.J., Saenger, P.H., Three-year efficacy and safety of LB03002, a once-weekly sustained-release growth hormone (GH) preparation, in prepubertal children with GH deficiency (GHD) (2012) Journal of Clinical Endocrinology and Metabolism, 97, pp. 400-407. , (doi:10.1210/jc.2011-2234)
  • Pfaffl, M.W., A new mathematical model for relative quantification in realtime RT-PCR (2001) Nucleic Acids Research, 29, pp. e45. , (doi:10.1093/nar/29.9.e45)
  • Quesnelle, K.M., Boehm, A.L., Grandis, J.R., STAT mediated EGFR signaling in cancer (2007) Journal of Cellular Biochemistry, 102, pp. 311-319. , (doi:10.1002/jcb.21475)
  • Ram, P.A., Waxman, D.J., Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone (2000) Journal of Biological Chemistry, 275, pp. 39487-39496. , (doi:10.1074/jbc.M004755200)
  • Riese, D.J., Stern, D.F., Specificity within the EGF family/ErbB receptor family signaling network (1998) BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology, 20, pp. 41-48. , (doi:10.1002/(SICI)1521-1878(199801)20:1!41::AID-BIES7O3.0.CO;2-V)
  • Singh, A.B., Harris, R.C., Autocrine, paracrine and juxtacrine signaling by EGFR ligands (2005) Cellular Signalling, 17, pp. 1183-1193. , (doi:10.1016/j.cellsig.2005.03.026)
  • Siobhan, L., Shereen, E., Acromegaly: re-thinking the cancer risk (2008) Reviews in Endocrine&Metabolic Disorders, 9, pp. 41-58. , (doi:10.1007/s11154-007-9063-z)
  • Soucek, L., Whitfield, J., Martins, C.P., Finch, A.J., Murphy, D.J., Sodir, N.M., Karnezis, A.N., Evan, G.I., Modelling Myc inhibition as a cancer therapy (2008) Nature, 455, pp. 679-683. , (doi:10.1038/nature07260)
  • Udy, G.B., Towers, R.P., Snell, R.G., Wilkins, R.J., Park, S.H., Ram, P.A., Waxman, D.J., Davey, H.W., Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression (1997) PNAS, 94, pp. 7239-7244. , (doi:10.1073/pnas.94.14.7239)
  • Veldhuis, J.D., Bowers, C.Y., Human GH pulsatility: an ensemble property regulated by age and gender (2003) Journal of Endocrinological Investigation, 26, pp. 799-813. , (doi:10.1007/BF03345229)
  • Waxman, D.J., O'Connor, C., Growth hormone regulation of sex-dependent liver gene expression (2006) Molecular Endocrinology, 20, pp. 2613-2629. , (doi:10.1210/me.2006-0007)
  • Waxman, D.J., Pampori, N.A., Ram, P.A., Agrawal, A.K., Shapiro, B.H., Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450 (1991) PNAS, 88, pp. 6868-6872. , (doi:10.1073/pnas.88.15.6868)
  • Wei, Y., Wang, Y., Kang, A., Wang, W., Ho, S.V., Gao, J., Ma, G., Su, Z., A novel sustained-release formulation of recombinant human growth hormone and its pharmacokinetic, pharmacodynamic and safety profiles (2012) Molecular Pharmaceutics, 9, pp. 2039-2048. , (doi:10.1021/mp300126t)
  • Wells, A., EGF receptor (1999) International Journal of Biochemistry&Cell Biology, 31, pp. 637-643. , (doi:10.1016/S1357-2725(99)00015-1)
  • Yuen, M.F., Wu, P.C., Lai, V.C., Lau, J.Y., Lai, C.L., Expression of c-Myc, c-Fos, and c-Jun in hepatocellular carcinoma (2001) Cancer, 91, pp. 106-112. , (doi:10.1002/1097-0142(20010101)91:1!106::AID-CNCR14O3.0.CO;2-2)

Citas:

---------- APA ----------
Díaz, M.E., Miquet, J.G., Rossi, S.P., Irene, P.E., Sotelo, A.I., Frungieri, M.B., Turyn, D.,..., González, L. (2014) . GH administration patterns differently regulate epidermal growth factor signaling. Journal of Endocrinology, 221(2), 309-323.
http://dx.doi.org/10.1530/JOE-13-0447
---------- CHICAGO ----------
Díaz, M.E., Miquet, J.G., Rossi, S.P., Irene, P.E., Sotelo, A.I., Frungieri, M.B., et al. "GH administration patterns differently regulate epidermal growth factor signaling" . Journal of Endocrinology 221, no. 2 (2014) : 309-323.
http://dx.doi.org/10.1530/JOE-13-0447
---------- MLA ----------
Díaz, M.E., Miquet, J.G., Rossi, S.P., Irene, P.E., Sotelo, A.I., Frungieri, M.B., et al. "GH administration patterns differently regulate epidermal growth factor signaling" . Journal of Endocrinology, vol. 221, no. 2, 2014, pp. 309-323.
http://dx.doi.org/10.1530/JOE-13-0447
---------- VANCOUVER ----------
Díaz, M.E., Miquet, J.G., Rossi, S.P., Irene, P.E., Sotelo, A.I., Frungieri, M.B., et al. GH administration patterns differently regulate epidermal growth factor signaling. J. Endocrinol. 2014;221(2):309-323.
http://dx.doi.org/10.1530/JOE-13-0447