Artículo

Stuart, K.; Brun, R.; Croft, S.; Fairlamb, A.; Gürtler, R.E.; McKerrow, J.; Reed, S.; Tarleton, R. "Kinetoplastids: Related protozoan pathogens, different diseases" (2008) Journal of Clinical Investigation. 118(4):1301-1310
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Abstract:

Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these "neglected diseases" are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better.

Registro:

Documento: Artículo
Título:Kinetoplastids: Related protozoan pathogens, different diseases
Autor:Stuart, K.; Brun, R.; Croft, S.; Fairlamb, A.; Gürtler, R.E.; McKerrow, J.; Reed, S.; Tarleton, R.
Filiación:Seattle Biomedical Research Institute, University of Washington, Seattle, WA, United States
Swiss Tropical Institute, Basel, Switzerland
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
School of Life Sciences, University of Dundee, Dundee, United Kingdom
Departamento de Ecología, Genética Y Evolución, Universidad de Buenos Aires, Buenos Aires, Argentina
Sandler Center for Basic Research in Parasitic Diseases, UCSF, San Francisco, CA, United States
Infectious Disease Research Institute, Seattle, WA, United States
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United States
Seattle Biomedical Research Institute, 307 Westlake Avenue N, Seattle, WA, United States
Palabras clave:amphotericin B lipid complex; benznidazole; eflornithine; insecticide; interleukin 1; interleukin 10; interleukin 12; interleukin 18; Leishmania vaccine; meglumine antimonate; melarsoprol; miltefosine; nifurtimox; paromomycin; pentamidine isethionate; stibogluconate sodium; suramin; toll like receptor 4; toll like receptor 7; toll like receptor 8; toll like receptor 9; transforming growth factor beta; Chagas disease; continuous infusion; flagellate; gene sequence; genome; human; infection control; Leishmania; Leishmania braziliensis; Leishmania donovani; Leishmania infantum; Leishmania major; Leishmania mexicana; Leishmania tropica; leishmaniasis; nonhuman; patient compliance; priority journal; protozoon; review; teratogenicity; Trypanosoma; Trypanosoma brucei; Trypanosoma cruzi; Trypanosoma gambiense; unspecified side effect; Animals; Antiprotozoal Agents; Genetic Vectors; Genome, Protozoan; Humans; Kinetoplastida; Mastigophora Infections; Protozoan Vaccines
Año:2008
Volumen:118
Número:4
Página de inicio:1301
Página de fin:1310
DOI: http://dx.doi.org/10.1172/JCI33945
Título revista:Journal of Clinical Investigation
Título revista abreviado:J. Clin. Invest.
ISSN:00219738
CODEN:JCINA
CAS:benznidazole, 22994-85-0; eflornithine, 67037-37-0, 70052-12-9; interleukin 12, 138415-13-1; interleukin 18, 189304-55-0; meglumine antimonate, 133-51-7; melarsoprol, 494-79-1; miltefosine, 58066-85-6; nifurtimox, 23256-30-6; paromomycin, 11035-13-5, 1263-89-4, 1390-73-4, 51795-47-2, 54597-56-7, 7542-37-2, 84420-34-8; pentamidine isethionate, 140-64-7; stibogluconate sodium, 16037-91-5; suramin, 129-46-4, 145-63-1; toll like receptor 4, 203811-83-0; toll like receptor 9, 352486-49-8, 390883-32-6; Antiprotozoal Agents; Protozoan Vaccines
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219738_v118_n4_p1301_Stuart

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Citas:

---------- APA ----------
Stuart, K., Brun, R., Croft, S., Fairlamb, A., Gürtler, R.E., McKerrow, J., Reed, S.,..., Tarleton, R. (2008) . Kinetoplastids: Related protozoan pathogens, different diseases. Journal of Clinical Investigation, 118(4), 1301-1310.
http://dx.doi.org/10.1172/JCI33945
---------- CHICAGO ----------
Stuart, K., Brun, R., Croft, S., Fairlamb, A., Gürtler, R.E., McKerrow, J., et al. "Kinetoplastids: Related protozoan pathogens, different diseases" . Journal of Clinical Investigation 118, no. 4 (2008) : 1301-1310.
http://dx.doi.org/10.1172/JCI33945
---------- MLA ----------
Stuart, K., Brun, R., Croft, S., Fairlamb, A., Gürtler, R.E., McKerrow, J., et al. "Kinetoplastids: Related protozoan pathogens, different diseases" . Journal of Clinical Investigation, vol. 118, no. 4, 2008, pp. 1301-1310.
http://dx.doi.org/10.1172/JCI33945
---------- VANCOUVER ----------
Stuart, K., Brun, R., Croft, S., Fairlamb, A., Gürtler, R.E., McKerrow, J., et al. Kinetoplastids: Related protozoan pathogens, different diseases. J. Clin. Invest. 2008;118(4):1301-1310.
http://dx.doi.org/10.1172/JCI33945