Artículo

Pereda, M.P.; Ledda, M.F.; Goldberg, V.; Chervín, A.; Carrizo, G.; Molina, H.; Müller, A.; Renner, U.; Podhajcer, O.; Arzt, E.; Stalla, G.K. "High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells" (2000) Journal of Clinical Endocrinology and Metabolism. 85(1):263-269
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Abstract:

Beside the digestion of the extracellular matrix during tumor invasion and metastasis, more recently, new functions for matrix metalloproteinases (MMPs) have been proposed. We studied the expression and function of these enzymes in pituitary cells. We observed the activities of MMP-2 and MMP-9 together with expression of membrane-type MMP and tissue inhibitor of metalloproteinase-1 in all types of human pituitary adenomas. We found surprisingly high levels of MMP activity and low levels of tissue inhibitor of metalloproteinases, indicating a high level of extracellular matrix-degrading activity in pituitary adenomas. To examine the function of metalloproteinase activity in pituitary cells we used the synthetic MMP inhibitor batimastat. These studies demonstrate that MMPs secreted by pituitary cells can release growth factors anchored to the extracellular matrix that, in turn, control pituitary cell proliferation and hormone secretion. These results define a new additional mechanism for the control of pituitary hormone secretion and indicate new potential therapeutic targets for pituitary adenomas.

Registro:

Documento: Artículo
Título:High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells
Autor:Pereda, M.P.; Ledda, M.F.; Goldberg, V.; Chervín, A.; Carrizo, G.; Molina, H.; Müller, A.; Renner, U.; Podhajcer, O.; Arzt, E.; Stalla, G.K.
Filiación:Department of Endocrinology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
Fundacion Campomar, CONICET, Universidad de Buenos Aires, Patricias Argentinas 435, 1405 Buenos Aires, Argentina
Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Buenos Aires, 1427 Buenos Aires, Argentina
Hospital Santa Lucía, 1232 Buenos Aires, Argentina
Hospital Ramos Mejía, 1221 Buenos Aires, Argentina
Department of Neurosurgery, University of Munich, 81377 Munich, Germany
Laboratory Fisiología y Biología Molecular, Universidad de Buenos Aires, Ciudad Universitaria (E.A.), 1428 Buenos Aires, Argentina
Department of Endocrinology, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
Palabras clave:batimastat; matrix metalloproteinase; adult; aged; article; cell proliferation; drug use; enzyme activity; female; growth regulation; human; hypophysis adenoma; hypophysis function; major clinical study; male; priority journal; Adenoma; Adult; Aged; Aged, 80 and over; Animals; Blotting, Northern; Cell Division; Female; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Middle Aged; Phenylalanine; Pituitary Gland; Pituitary Hormones; Pituitary Neoplasms; Protease Inhibitors; Rats; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured; Tumor Stem Cells
Año:2000
Volumen:85
Número:1
Página de inicio:263
Página de fin:269
DOI: http://dx.doi.org/10.1210/jc.85.1.263
Título revista:Journal of Clinical Endocrinology and Metabolism
Título revista abreviado:J. Clin. Endocrinol. Metab.
ISSN:0021972X
CODEN:JCEMA
CAS:batimastat, 130370-60-4; Matrix Metalloproteinase 2, EC 3.4.24.24; Matrix Metalloproteinase 9, EC 3.4.24.35; Matrix Metalloproteinases, EC 3.4.24.-; Phenylalanine, 63-91-2; Pituitary Hormones; Protease Inhibitors; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2, 127497-59-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0021972X_v85_n1_p263_Pereda

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Citas:

---------- APA ----------
Pereda, M.P., Ledda, M.F., Goldberg, V., Chervín, A., Carrizo, G., Molina, H., Müller, A.,..., Stalla, G.K. (2000) . High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells. Journal of Clinical Endocrinology and Metabolism, 85(1), 263-269.
http://dx.doi.org/10.1210/jc.85.1.263
---------- CHICAGO ----------
Pereda, M.P., Ledda, M.F., Goldberg, V., Chervín, A., Carrizo, G., Molina, H., et al. "High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells" . Journal of Clinical Endocrinology and Metabolism 85, no. 1 (2000) : 263-269.
http://dx.doi.org/10.1210/jc.85.1.263
---------- MLA ----------
Pereda, M.P., Ledda, M.F., Goldberg, V., Chervín, A., Carrizo, G., Molina, H., et al. "High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells" . Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 1, 2000, pp. 263-269.
http://dx.doi.org/10.1210/jc.85.1.263
---------- VANCOUVER ----------
Pereda, M.P., Ledda, M.F., Goldberg, V., Chervín, A., Carrizo, G., Molina, H., et al. High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells. J. Clin. Endocrinol. Metab. 2000;85(1):263-269.
http://dx.doi.org/10.1210/jc.85.1.263