Abstract:
Among the biologically required first row, late d-block metals from MnII to ZnII, the catalytic and structural reach of ZnII ensures that this essential micronutrient touches nearly every major metabolic process or pathway in the cell. Zn is also toxic in excess, primarily because it is a highly competitive divalent metal and will displace more weakly bound transition metals in the active sites of metalloenzymes if left unregulated. The vertebrate innate immune system uses several strategies to exploit this "Achilles heel" of microbial physiology, but bacterial evolution has responded in kind. This review highlights recent insights into transcriptional, transport, and trafficking mechanisms that pathogens use to "win the fight" over zinc and thrive in an otherwise hostile environment. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.
Registro:
Documento: |
Artículo
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Título: | Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface |
Autor: | Capdevila, D.A.; Wang, J.; Giedroc, D.P. |
Filiación: | Dept. of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN 47405-7102, United States Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405-7102, United States Departamento de Quimica Inorganica, Analitica y Quimica Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, C1428EHA, Argentina
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Palabras clave: | Manganese; Pathogens; Structural metals; Transition metals; Zinc; Achilles heel; Bacterial evolution; Divalent metals; Hostile environments; Innate immune systems; Metabolic process; Metalloenzymes; Microbial physiology; Metals; bacillithiol; cyanocobalamin; glutathione; reactive oxygen metabolite; RNA polymerase; siderophore; thiol derivative; unclassified drug; zinc ion; zinc; Acinetobacter baumannii; allostasis; allosterism; Bacillus subtilis; bacterial outer membrane; bacterial strain; bioavailability; carboxy terminal sequence; cation transport; cytoplasm; DNA binding; Escherichia coli; host pathogen interaction; hydrolysis; in vivo study; molecular recognition; Mycobacterium tuberculosis; nonhuman; priority journal; Salmonella enterica; Shigella sonnei; Short Survey; Staphylococcus aureus; Streptococcus pneumoniae; Streptomyces coelicolor; transcription regulation; zinc efflux; zinc homeostasis; zinc metallostasis; zinc uptake; animal; bacterial phenomena and functions; bacterium; host pathogen interaction; human; metabolism; physiology; Animals; Bacteria; Bacterial Physiological Phenomena; Host-Pathogen Interactions; Humans; Zinc |
Año: | 2016
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Volumen: | 291
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Número: | 40
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Página de inicio: | 20858
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Página de fin: | 20868
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DOI: |
http://dx.doi.org/10.1074/jbc.R116.742023 |
Título revista: | Journal of Biological Chemistry
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Título revista abreviado: | J. Biol. Chem.
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ISSN: | 00219258
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CODEN: | JBCHA
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CAS: | cyanocobalamin, 53570-76-6, 68-19-9, 8064-09-3; glutathione, 70-18-8; RNA polymerase, 9014-24-8; thiol derivative, 13940-21-1; zinc ion, 23713-49-7; zinc, 7440-66-6, 14378-32-6; Zinc
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219258_v291_n40_p20858_Capdevila |
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Citas:
---------- APA ----------
Capdevila, D.A., Wang, J. & Giedroc, D.P.
(2016)
. Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface. Journal of Biological Chemistry, 291(40), 20858-20868.
http://dx.doi.org/10.1074/jbc.R116.742023---------- CHICAGO ----------
Capdevila, D.A., Wang, J., Giedroc, D.P.
"Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface"
. Journal of Biological Chemistry 291, no. 40
(2016) : 20858-20868.
http://dx.doi.org/10.1074/jbc.R116.742023---------- MLA ----------
Capdevila, D.A., Wang, J., Giedroc, D.P.
"Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface"
. Journal of Biological Chemistry, vol. 291, no. 40, 2016, pp. 20858-20868.
http://dx.doi.org/10.1074/jbc.R116.742023---------- VANCOUVER ----------
Capdevila, D.A., Wang, J., Giedroc, D.P. Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface. J. Biol. Chem. 2016;291(40):20858-20868.
http://dx.doi.org/10.1074/jbc.R116.742023