Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Mutations in N-RAS and B-RAF, which commonly occur in melanomas, result in constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated protein kinase (ERK) signaling. Active ERK increases expression and activity of the c-Jun transcription factor, linking ERK and Jun N-terminal kinase (JNK) cascades. Here, we show that c-Jun regulates transcription of phosphoinositide-dependent kinase 1 (PDK1) with a concomitant impact on Akt and protein kinase C (PKC) activity and related substrates. Inhibition of c-Jun reduces PDK1 expression and attenuates Akt and PKC activity, which can be restored by exogenous PDK1. c-Jun regulation of PDK1 in melanoma contributes to growth rate and the ability to form tumors in mice. Correspondingly, increased levels of c-Jun in melanoma cell lines coincide with up-regulation of PDK1 and phosphorylation of PKC and Akt. The identification of c-Jun as a transcriptional regulator of PDK1 expression highlights key mechanisms underlying c-Jun oncogenic activity, and provides new insight into the nature of up-regulated Akt and PKC in melanoma. © 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

Registro:

Documento: Artículo
Título:c-Jun regulates phosphoinositide-dependent kinase 1 transcription: Implication for Akt and protein kinase C activities melanoma tumorigenesis
Autor:Lopez-Bergami, P.; Kim, H.; Dewing, A.; Goydos, J.; Aaronson, S.; Ronai, Z.
Filiación:Signal Transduction Program, The Burnham Institute for Medical Research, La Jolla, CA 92037, United States
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, United States
Division of Surgical Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States
10901 N. Torrey Pines Rd., La Jolla, CA 92037, United States
Instituto de Biologia y Medicina Experimental, Vuelta de Obligado 2490, Buenos Aires 1428, Argentina
Palabras clave:Extracellular signal-regulated protein kinase; Jun N-terminal kinase; Melanoma cells; Mitogen activated protein kinase; Oncogenic activities; Phosphoinositide-dependent kinase 1; Protein kinase c activities; Transcriptional regulator; Tumorigenesis; Up-regulation; Cell culture; Dermatology; Enzyme activity; Phosphorylation; Transcription; Transcription factors; Oncology; phosphoinositide dependent protein kinase 1; protein c jun; protein kinase B; protein kinase C; animal experiment; animal model; article; carcinogenesis; controlled study; enzyme activity; enzyme phosphorylation; human; human cell; melanoma; mouse; nonhuman; priority journal; protein function; regulatory mechanism; transcription regulation; tumor growth; upregulation; Animals; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-jun; Transcription, Genetic; Transplantation, Heterologous; Mus
Año:2010
Volumen:285
Número:2
Página de inicio:903
Página de fin:913
DOI: http://dx.doi.org/10.1074/jbc.M109.075630
Título revista:Journal of Biological Chemistry
Título revista abreviado:J. Biol. Chem.
ISSN:00219258
CODEN:JBCHA
CAS:protein kinase B, 148640-14-6; protein kinase C, 141436-78-4; Extracellular Signal-Regulated MAP Kinases, 2.7.11.24; JNK Mitogen-Activated Protein Kinases, 2.7.11.24; Protein-Serine-Threonine Kinases, 2.7.11.1; Proto-Oncogene Proteins c-akt, 2.7.11.1; Proto-Oncogene Proteins c-jun; pyruvate dehydrogenase (acetyl-transferring) kinase, 2.7.11.2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219258_v285_n2_p903_LopezBergami

Referencias:

  • Vogt, P.K., (2001) Oncogene, 20, pp. 2365-2377
  • Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., Davis, N., Dicks, E., Ewing, R., Floyd, Y., Gray, K., Hall, S., Hawes, R., Hughes, J., Kosmidou, V., Menzies, A., Mould, C., Parker, A., Stevens, C., Watt, S., Hooper, S., Wilson, R., Jayatilake, H., Gusterson, B. A., Cooper, C., Shipley, J., Hargrave, D., Pritchard-Jones, K., Maitland, N., Chenevix-Trench, G., Riggins, G. J., Bigner, D. D., Palmieri, G., Cossu, A., Flanagan, A., Nicholson, A., Ho, J. W., Leung, S. Y., Yuen, S. T., Weber, B. L., Seigler, H. F., Darrow, T. L., Paterson, H., Marais, R., Marshall, C. J., Wooster, R., Stratton, M. R., and Futreal, P. A. (2002) Nature 417, 949-954; Gorden, A., Osman, I., Gai, W., He, D., Huang, W., Davidson, A., Houghton, A.N., Polsky, D., (2003) Cancer Res, 63, pp. 3955-3957
  • Lopez-Bergami, P., Huang, C., Goydos, J.S., Yip, D., Bar-Eli, M., Herlyn, M., Smalley, K.S., Ronai, Z., (2007) Cancer Cell, 11, pp. 447-460
  • Behrens, A., Jochum, W., Sibilia, M., Wagner, E.F., (2000) Oncogene, 19, pp. 2657-2663
  • Mariani, O., Brennetot, C., Coindre, J.M., Gruel, N., Ganem, C., Delattre, O., Stern, M.H., Aurias, A., (2007) Cancer Cell, 11, pp. 361-374
  • Vleugel, M.M., Greijer, A.E., Bos, R., van der Wall, E., van Diest, P.J., (2006) Hum. Pathol, 37, pp. 668-674
  • Maeno, K., Masuda, A., Yanagisawa, K., Konishi, H., Osada, H., Saito, T., Ueda, R., Takahashi, T., (2006) Oncogene, 25, pp. 271-277
  • Eferl, R., Ricci, R., Kenner, L., Zenz, R., David, J.P., Rath, M., Wagner, E.F., (2003) Cell, 112, pp. 181-192
  • Bhoumik, A., Jones, N., Ronai, Z., (2004) Proc. Natl. Acad. Sci. U.S.A, 101, pp. 4222-4227
  • Matthews, C.P., Birkholz, A.M., Baker, A.R., Perella, C.M., Beck Jr., G.R., Young, M.R., Colburn, N.H., (2007) Cancer Res, 67, pp. 2430-2438
  • Mora, A., Komander, D., van Aalten, D.M., Alessi, D.R., (2004) Semin. Cell Dev. Biol, 15, pp. 161-170
  • Storz, P., Toker, A., (2002) Front. Biosci, 7, pp. d886-d902
  • Alessi, D.R., James, S.R., Downes, C.P., Holmes, A.B., Gaffney, P.R., Reese, C.B., Cohen, P., (1997) Curr. Biol, 7, pp. 261-269
  • Huang, J., Manning, B.D., (2009) Biochem. Soc. Trans, 37, pp. 217-222
  • Makris, C., Voisin, L., Giasson, E., Tudan, C., Kaplan, D.R., Meloche, S., (2002) Oncogene, 21, pp. 7891-7896
  • López-Bergami, P., Habelhah, H., Bhoumik, A., Zhang, W., Wang, L.H., Ronai, Z., (2005) Mol. Cell, 19, pp. 309-320
  • Wick, M.J., Ramos, F.J., Chen, H., Quon, M.J., Dong, L.Q., Liu, F., (2003) J. Biol. Chem, 278, pp. 42913-42919
  • Chan, T.O., Rodeck, U., Chan, A.M., Kimmelman, A.C., Rittenhouse, S.E., Panayotou, G., Tsichlis, P.N., (2002) Cancer Cell, 1, pp. 181-191
  • Lopez-Bergami, P., Ronai, Z., (2008) Int. J. Biochem. Cell Biol, 40, pp. 1055-1064
  • Newton, A.C., (2003) Biochem. J, 370, pp. 361-371
  • Johnson, R., Spiegelman, B., Hanahan, D., Wisdom, R., (1996) Mol. Cell. Biol, 16, pp. 4504-4511
  • Chen, B.K., Chang, W.C., (2000) Proc. Natl. Acad. Sci. U.S.A, 97, pp. 10406-10411
  • Kardassis, D., Papakosta, P., Pardali, K., Moustakas, A., (1999) J. Biol. Chem, 274, pp. 29572-29581
  • Melnikova, I.N., Gardner, P.D., (2001) J. Biol. Chem, 276, pp. 19040-19045
  • Wang, Y.N., Chang, W.C., (2003) J. Biol. Chem, 278, pp. 45848-45857
  • Wasylyk, B., Wasylyk, C., Flores, P., Begue, A., Leprince, D., Stehelin, D., (1990) Nature, 346, pp. 191-193
  • Logan, S.K., Garabedian, M.J., Campbell, C.E., Werb, Z., (1996) J. Biol. Chem, 271, pp. 774-782
  • Bassuk, A.G., Leiden, J.M., (1995) Immunity, 3, pp. 223-237
  • Majérus, M.A., Bibollet-Ruche, F., Telliez, J.B., Wasylyk, B., Bailleul, B., (1992) Nucleic Acids Res, 20, pp. 2699-2703
  • Feldman, R.I., Wu, J.M., Polokoff, M.A., Kochanny, M.J., Dinter, H., Zhu, D., Biroc, S.L., Arnaiz, D.O., (2005) J. Biol. Chem, 280, pp. 19867-19874
  • Flynn, P., Mellor, H., Casamassima, A., Parker, P.J., (2000) J. Biol. Chem, 275, pp. 11064-11070
  • Wick, M.J., Dong, L.Q., Riojas, R.A., Ramos, F.J., Liu, F., (2000) J. Biol. Chem, 275, pp. 40400-40406
  • Balendran, A., Hare, G.R., Kieloch, A., Williams, M.R., Alessi, D.R., (2000) FEBS Lett, 484, pp. 217-223
  • Vivanco, I., Palaskas, N., Tran, C., Finn, S.P., Getz, G., Kennedy, N.J., Jiao, J., Sawyers, C.L., (2007) Cancer Cell, 11, pp. 555-569
  • Maurer, M., Su, T., Saal, L.H., Koujak, S., Hopkins, B.D., Barkley, C.R., Wu, J., Parsons, R., (2009) Cancer Res, 69, pp. 6299-6306
  • Vasudevan, K. M., Barbie, D. A., Davies, M. A., Rabinovsky, R., McNear, C. J., Kim, J. J., Hennessy, B. T., Tseng, H., Pochanard, P., Kim, S. Y., Dunn, I. F., Schinzel, A. C., Sandy, P., Hoersch, S., Sheng, Q., Gupta, P. B., Boehm, J. S., Reiling, J. H., Silver, S., Lu, Y., Stemke-Hale, K., Dutta, B., Joy, C., Sahin, A. A., Gonzalez-Angulo, A. M., Lluch, A., Rameh, L. E., Jacks, T., Root, D. E., Lander, E. S., Mills, G. B., Hahn, W. C., Sellers, W. R., and Garraway, L. A. (2009) Cancer Cell 16, 21-32; Lawlor, M.A., Mora, A., Ashby, P.R., Williams, M.R., Murray-Tait, V., Malone, L., Prescott, A.R., Alessi, D.R., (2002) EMBO J, 21, pp. 3728-3738
  • Jiang, T., Qiu, Y., (2003) J. Biol. Chem, 278, pp. 15789-15793
  • Lopez-Bergami, P., Fitchman, B., Ronai, Z., (2008) Photochem. Photobiol, 84, pp. 289-306

Citas:

---------- APA ----------
Lopez-Bergami, P., Kim, H., Dewing, A., Goydos, J., Aaronson, S. & Ronai, Z. (2010) . c-Jun regulates phosphoinositide-dependent kinase 1 transcription: Implication for Akt and protein kinase C activities melanoma tumorigenesis. Journal of Biological Chemistry, 285(2), 903-913.
http://dx.doi.org/10.1074/jbc.M109.075630
---------- CHICAGO ----------
Lopez-Bergami, P., Kim, H., Dewing, A., Goydos, J., Aaronson, S., Ronai, Z. "c-Jun regulates phosphoinositide-dependent kinase 1 transcription: Implication for Akt and protein kinase C activities melanoma tumorigenesis" . Journal of Biological Chemistry 285, no. 2 (2010) : 903-913.
http://dx.doi.org/10.1074/jbc.M109.075630
---------- MLA ----------
Lopez-Bergami, P., Kim, H., Dewing, A., Goydos, J., Aaronson, S., Ronai, Z. "c-Jun regulates phosphoinositide-dependent kinase 1 transcription: Implication for Akt and protein kinase C activities melanoma tumorigenesis" . Journal of Biological Chemistry, vol. 285, no. 2, 2010, pp. 903-913.
http://dx.doi.org/10.1074/jbc.M109.075630
---------- VANCOUVER ----------
Lopez-Bergami, P., Kim, H., Dewing, A., Goydos, J., Aaronson, S., Ronai, Z. c-Jun regulates phosphoinositide-dependent kinase 1 transcription: Implication for Akt and protein kinase C activities melanoma tumorigenesis. J. Biol. Chem. 2010;285(2):903-913.
http://dx.doi.org/10.1074/jbc.M109.075630