Abstract:
This paper reports the in vitro antifungal activity of propolis extracts from the province of Tucumán (Argentina) as well as the identification of their main antifungal compounds and botanical origin. The antifungal activity was determined by the microdilution technique, using reference microorganisms and clinical isolates. All dermatophytes and yeasts tested were strongly inhibited by different propolis extracts (MICs between 16 and 125 μg mL -1). The most susceptible species were Microsporum gypseum, Trichophyton mentagrophytes, and Trichophyton rubrum. The main bioactive compounds were 2′,4′-dihydroxy-3′-methoxychalcone 2 and 2′,4′-dihydroxychalcone 3. Both displayed strong activity against clinical isolates of T. rubrum and T. mentagrophytes (MICs and MFCs between 1.9 and 2.9 μg mL-1). Additionally, galangin 5, pinocembrin 6, and 7-hydroxy-8-methoxyflavanone 9 were isolated from propolis samples and Zuccagnia punctata exudates, showing moderate antifungal activity. This is the first study matching the chemical profile of Z punctata Cav. exudates with their corresponding propolis, giving strong evidence on the botanical origin of the studied propolis. © 2009 American Chemical Society.
Registro:
Documento: |
Artículo
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Título: | Argentinean propolis from Zuccagnia punctata cav. (Caesalpinieae) exudates: Phytochemical characterization and antifungal activity |
Autor: | Agüero, M.B.; Gonzalez, M.; Lima, B.; Svetaz, L.; Sánchez, M.; Zacchino, S.; Feresin, G.E.; Schmeda-Hirschmann, G.; Palermo, J.; Daniel Wunderlin, A.N.D.; Tapia, A. |
Filiación: | Instituto de Biotecnología - Instituto de Ciencias Básicas, Universidad Nacional de San Juan, Avenida Libertador General San Martín 1109 (O), 5400 San Juan, Argentina Facultad de Ciencias Exactas y Tecnología, Universidad Nacional de Tucumán, Avenida Roca 1700, CP 4000 San Miguel de Tucumán, Argentina Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Del Rosario, Suipacha 531, CP 2000 Rosario, Argentina UMYMFOR, Departamento de Química Orgánica, Ciudad Universitaria, Piso 3, Pabellón 2, Buenos Aires 1428, Argentina Labofatorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile Facultad Ciencias Químicas-ISIDSA-CIBICI, Universidad Nacional de Córdoba-CONICET, Ciudad Universitaria, 5000 Córdoba, Argentina
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Palabras clave: | Antifungal activity; Argentinean propolis; Chalcones; HPLC-ESI-MS/MS; Arthroderma benhamiae; Arthroderma gypseum; Arthrodermataceae; Caesalpinieae; Trichophyton rubrum; Zuccagnia punctata |
Año: | 2010
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Volumen: | 58
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Número: | 1
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Página de inicio: | 194
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Página de fin: | 201
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DOI: |
http://dx.doi.org/10.1021/jf902991t |
Título revista: | Journal of Agricultural and Food Chemistry
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Título revista abreviado: | J. Agric. Food Chem.
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ISSN: | 00218561
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CODEN: | JAFCA
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00218561_v58_n1_p194_Aguero |
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Citas:
---------- APA ----------
Agüero, M.B., Gonzalez, M., Lima, B., Svetaz, L., Sánchez, M., Zacchino, S., Feresin, G.E.,..., Tapia, A.
(2010)
. Argentinean propolis from Zuccagnia punctata cav. (Caesalpinieae) exudates: Phytochemical characterization and antifungal activity. Journal of Agricultural and Food Chemistry, 58(1), 194-201.
http://dx.doi.org/10.1021/jf902991t---------- CHICAGO ----------
Agüero, M.B., Gonzalez, M., Lima, B., Svetaz, L., Sánchez, M., Zacchino, S., et al.
"Argentinean propolis from Zuccagnia punctata cav. (Caesalpinieae) exudates: Phytochemical characterization and antifungal activity"
. Journal of Agricultural and Food Chemistry 58, no. 1
(2010) : 194-201.
http://dx.doi.org/10.1021/jf902991t---------- MLA ----------
Agüero, M.B., Gonzalez, M., Lima, B., Svetaz, L., Sánchez, M., Zacchino, S., et al.
"Argentinean propolis from Zuccagnia punctata cav. (Caesalpinieae) exudates: Phytochemical characterization and antifungal activity"
. Journal of Agricultural and Food Chemistry, vol. 58, no. 1, 2010, pp. 194-201.
http://dx.doi.org/10.1021/jf902991t---------- VANCOUVER ----------
Agüero, M.B., Gonzalez, M., Lima, B., Svetaz, L., Sánchez, M., Zacchino, S., et al. Argentinean propolis from Zuccagnia punctata cav. (Caesalpinieae) exudates: Phytochemical characterization and antifungal activity. J. Agric. Food Chem. 2010;58(1):194-201.
http://dx.doi.org/10.1021/jf902991t