Artículo

Cardinal, M.V.; Lauricella, M.A.; Ceballos, L.A.; Lanati, L.; Marcet, P.L.; Levin, M.J.; Kitron, U.; Gürtler, R.E.; Schijman, A.G. "Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina" (2008) International Journal for Parasitology. 38(13):1533-1543
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Genetic diversity of Trypanosoma cruzi populations and parasite transmission dynamics have been well documented throughout the Americas, but few studies have been conducted in the Gran Chaco ecoregion, one of the most highly endemic areas for Chagas disease, caused by T. cruzi. In this study, we assessed the distribution of T. cruzi lineages (identified by PCR strategies) in Triatoma infestans, domestic dogs, cats, humans and sylvatic mammals from two neighbouring rural areas with different histories of transmission and vector control in northern Argentina. Lineage II predominated amongst the 99 isolates characterised and lineage I amongst the six isolates obtained from sylvatic mammals. T. cruzi lineage IIe predominated in domestic habitats; it was found in 87% of 54 isolates from Tr. infestans, in 82% of 33 isolates from dogs, and in the four cats found infected. Domestic and sylvatic cycles overlapped in the study area in the late 1980s, when intense domestic transmission occurred, and still overlap marginally. The introduction of T. cruzi from sylvatic into domestic habitats is likely to occur very rarely in the current epidemiological context. The household distribution of T. cruzi lineages showed that Tr. infestans, dogs and cats from a given house compound shared the same parasite lineage in most cases. Based on molecular evidence, this result lends further support to the importance of dogs and cats as domestic reservoir hosts of T. cruzi. We believe that in Argentina, this is the first time that lineage IIc has been isolated from naturally infected domestic dogs and Tr. infestans. © 2008 Australian Society for Parasitology Inc.

Registro:

Documento: Artículo
Título:Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina
Autor:Cardinal, M.V.; Lauricella, M.A.; Ceballos, L.A.; Lanati, L.; Marcet, P.L.; Levin, M.J.; Kitron, U.; Gürtler, R.E.; Schijman, A.G.
Filiación:Laboratorio de Eco-Epidemiología, Departamento de Ecología, Genética y Evolución, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto Nacional de Parasitología Dr. Mario Fatala Chabén-ANLIS, Buenos Aires, Argentina
Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI-CONICET), Vuelta de Obligado 2490 Buenos Aires, Argentina
Department of Environmental Studies, Emory University, Atlanta, United States
Palabras clave:Cats; Chagas disease; Dogs; Lineage; Surveillance; Triatoma infestans; Trypanosoma cruzi; Vector control; canid; Chagas disease; disease vector; epidemiology; felid; genetic variation; parasite transmission; protozoan; rural area; spatial distribution; adult; animal experiment; animal model; Argentina; article; controlled study; disease transmission; domestic animal; geographical variation (species); household; human; molecular epidemiology; mouse; nonhuman; polymerase chain reaction; rural area; Trypanosoma cruzi; trypanosomiasis; vector control; Adult; Aged; Animals; Animals, Domestic; Animals, Wild; Argentina; Cat Diseases; Cats; Chagas Disease; Dog Diseases; Dogs; Feces; Female; Humans; Male; Middle Aged; Molecular Epidemiology; Rural Health; Triatoma; Trypanosoma cruzi; Young Adult; Argentina; South America; Canis familiaris; Mammalia; Triatoma infestans; Trypanosoma cruzi
Año:2008
Volumen:38
Número:13
Página de inicio:1533
Página de fin:1543
DOI: http://dx.doi.org/10.1016/j.ijpara.2008.04.010
Título revista:International Journal for Parasitology
Título revista abreviado:Int. J. Parasitol.
ISSN:00207519
CODEN:IJPYB
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00207519_v38_n13_p1533_Cardinal

Referencias:

  • Barnabé, C., Brissé, S., Tibayrenc, M., Population structure and genetic typing of Trypanosoma cruzi, the agent of Chagas disease: a multilocus enzyme electrophoresis approach (2000) Parasitology, 120, pp. 513-526
  • Barreto, M.P., 1975. Possible role of wild mammals and triatomines in the transmission of Trypanosoma cruzi to man. In: New Approaches in American Trypanosomiasis Research. Washington, PAHO/WHO, (Scientific Publication n° 318) pp. 307-318; Bosseno, M.F., Telleria, J., Vargas, F., Yaksic, N., Noireau, F., Morin, A., Brenière, S.F., Trypanosoma cruzi: study of the distribution of two widespread clonal genotypes in Bolivian Triatoma infestans vectors shows a high frequency of mixed infections (1996) Exp. Parasitol., 83, pp. 275-282
  • Brenière, S.F., Bosseno, M.F., Noireau, F., Yacsik, N., Liegeard, P., Aznar, C., Hontebeyrie, M., Integrate study of a Bolivian population infected by Trypanosoma cruzi, the agent of Chagas disease (2002) Mem. Inst. Oswaldo Cruz, 97, pp. 289-295
  • Brisse, S., Verhoef, J., Tibayrenc, M., Characterisation of large and small subunit rRNA and mini-exon genes further supports the distinction of six Trypanosoma cruzi lineages (2001) Int. J. Parasitol., 31, pp. 1218-1226
  • Burgos, J.M., Begher, S.B., Freitas, J.M., Bisio, M., Duffy, T., Altcheh, J., Teijeiro, R., Schijman, A.G., Molecular diagnosis and typing of Trypanosoma cruzi populations and lineages in cerebral Chagas disease in a patient with AIDS (2005) Am. J. Trop. Med. Hyg., 73, pp. 1016-1018
  • Burgos, J.M., Altcheh, J., Bisio, M., Duffy, T., Valadares, H.M., Seidenstein, M.E., Piccinali, R., Schijman, A.G., Direct molecular profiling of minicircle signatures and lineages of Trypanosoma cruzi bloodstream populations causing congenital Chagas disease (2007) Int. J. Parasitol., 37, pp. 1319-1327
  • Burgos, J.M., Begher, S., Valadares Silva, H., Bisio, M., Duffy, T., Levin, M.J., Macedo, A.M., Schijman, A.G., Case report: molecular identification of Trypanosoma cruzi I tropism for central nervous system in Chagas reactivation due to AIDS (2008) Am. J. Trop. Med. Hyg., 78, pp. 294-297
  • Carcavallo, R.U., Martinez, A., Entomoepidemiología de la República Argentina (1968) Investigaciones Científicas de las Fuerzas Armadas Argentinas, 1, pp. 76-92
  • Cardinal, M.V., Castañera, M.B., Lauricella, M.A., Cecere, M.C., Ceballos, L.A., Vazquez-Prokopec, G.M., Kitron, U., Gürtler, R.E., A prospective study of the effects of sustained vector surveillance following community-wide insecticide application on Trypanosoma cruzi infection of dogs and cats in rural northwestern Argentina (2006) Am. J. Trop. Med. Hyg., 75, pp. 753-761
  • Cardinal, M.V., Lauricella, M.A., Marcet, P.L., Orozco, M.M., Kitron, U., Gürtler, R.E., Impact of community-based vector control on house infestation and Trypanosoma cruzi infection in Triatoma infestans, dogs and cats in the Argentine Chaco (2007) Acta Trop., 103, pp. 201-211
  • Ceballos, L.A., Cardinal, M.V., Vazquez-Prokopec, G.M., Lauricella, M.A., Orozco, M.M., Cortinas, R., Schijman, A.G., Gürtler, R.E., Long-term reduction of Trypanosoma cruzi infection in sylvatic mammals following deforestation and sustained vector surveillance in northwestern Argentina (2006) Acta Trop., 98, pp. 286-296
  • Cohen, J.E., Gürtler, R.E., Modeling household transmission of American Trypanosomiasis (2001) Science, 293, pp. 694-698
  • Chapman, M.D., Baggaley, R.C., Godfrey-Fausset, P.F., Malpas, T.J., White, G., Canese, J., Miles, M.A., Trypanosoma cruzi from the Paraguayan Chaco: isoenzyme profiles of strains isolated at Makthlawaiya (1984) J. Protozool., 31, pp. 482-486
  • Cortez, M.R., Pinho, A.P., Cuervo, P., Alfaro, F., Solano, M., Xavier, S.C., D'Andrea, P.S., Jansen, A.M., Trypanosoma cruzi (Kinetoplastida Trypanosomatidae): ecology of the transmission cycle in the wild environment of the Andean valley of Cochabamba, Bolivia (2006) Exp. Parasitol., 114, pp. 305-313
  • De Luca d'Oro, G.M., Gardenal, C.N., Perret, B., Crisci, J.V., Montamat, E.E., Genetic structure of Trypanosoma cruzi populations from Argentina estimated from enzyme polymorphism (1993) Parasitology, 107, pp. 405-410
  • Diosque, P., Barnabé, C., Padilla, A., Marco, J., Cardozo, R., Cimino, R., Nasserd, J., Basombrío, M., Multilocus enzyme electrophoresis analysis of Trypanosoma cruzi isolates from a geographically restricted endemic area for Chagas' disease in Argentina (2003) Int. J. Parasitol., 33, pp. 997-1003
  • Diotaiuti, L., Pereira, A.S., Loiola, C.F., Fernandes, A.J., Schofield, C.J., Dujardin, J.P., Pinto Dias, J.C., Chiari, E., Inter-relation of sylvatic and domestic transmission of Trypanosoma cruzi in areas with and without domestic vectorial transmission in Minas Gerais, Brazil (1995) Mem. Inst. Oswaldo Cruz, 90, pp. 443-448
  • dos Santos, A.H., da Silva, I.G., Rassi, A., A comparative study between natural and artificial xenodiagnosis in chronic Chagas' disease patients (1995) Rev. Soc. Bras. Med. Trop., 28, pp. 367-373
  • Gürtler, R.E., Cecere, M.C., Castañera, M.B., Canale, D.M., Lauricella, M.A., Chuit, R., Cohen, J.E., Segura, E.L., Probability of infection with Trypanosoma cruzi of the vector Triatoma infestans fed on infected humans and dogs in northwest Argentina (1996) Am. J. Trop. Med. Hyg., 55, pp. 24-31
  • Gürtler, R.E., Cohen, J.E., Cecere, M.C., Chuit, R., Shifting host choices of the vector of Chagas diseaseTriatoma infestans in relation to the availability of hosts in houses in north-west Argentina (1997) J. Appl. Ecol., 34, pp. 699-715
  • Gürtler, R.E., Cecere, M.C., Lauricella, M.A., Petersen, R.M., Canale, D., Castañera, M.B., Chuit, R., Cohen, J.E., Incidence of Trypanosoma cruzi infection among children following domestic reinfestation after insecticide spraying in rural northwestern Argentina (2005) Am. J. Trop. Med. Hyg., 73, pp. 95-103
  • Gürtler, R.E., 2007. Eco-epidemiología regional de la transmisión vectorial: Enfermedad de Chagas en el Gran Chaco. In: Silveira, A.C., (Ed.), La enfermedad de Chagas. A la puerta de los 100 años del conocimiento de una endemia americana ancestral. Organización Panamericana de la Salud- Fundación Mundo Sano. Buenos Aires, pp. 137-155; Gürtler, R.E., Cecere, M.C., Lauricella, M.A., Cardinal, M.V., Kitron, U., Cohen, J.E., Domestic dogs and cats as sources of Trypanosoma cruzi infection in rural northwestern Argentina (2007) Parasitology, 134, pp. 69-82
  • Gürtler, R.E., Kitron, U., Cecere, M.C., Segura, E.L., Cohen, J.E., Sustainable vector control and management of Chagas disease in the Gran Chaco, Argentina (2007) Proc. Nat. Acad. Sci. USA, 104, pp. 16194-16199
  • Herrera, H.M., Rademaker, V., Abreu, U.G.P., D'Andrea, P.S., Jansen, A.M., Variables that modulate the spatial distribution of Trypanosoma cruzi and Trypanosoma evansi in the Brazilian Pantanal (2007) Acta Trop., 102, pp. 55-62
  • Higo, H., Miura, S., Horio, M., Mimori, T., Hamano, S., Agatsuma, T., Yanagi, T., Himeno, K., Genotypic variation among lineages of Trypanosoma cruzi and its geographic aspects (2004) Parasitol. Int., 53, pp. 337-344
  • Hoff, R., Mott, K.E., Franca Silva, J., Menezes, V., Hoff, J.N., Barret, T.V., Sherlock, I., Prevalence of parasitemia and seroreactivity to Trypanosoma cruzi in a rural population of northeast Brazil (1979) Am. J. Trop. Med. Hyg., 28, pp. 461-466
  • Lauricella, M.A., Stariolo, R.L., Riarte, A.R., Segura, E.L., Gürtler, R.E., Distribution and pathogenicity of Trypanosoma cruzi isolated from peridomestic populations of Triatoma infestans and Triatoma guasayana from rural western Argentina (2005) Mem. Inst. Oswaldo Cruz, 100, pp. 123-129
  • Macedo, A.M., Machado, C.R., Oliveira, R.P., Pena, S.D.J., Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of Chagas disease (2004) Mem. Inst. Oswaldo Cruz, 99, pp. 1-12
  • Marcet, P.L., Duffy, T., Cardinal, M.V., Lauricella, M.A., Levin, M.J., Kitron, U., Gürtler, R.E., Schijman, A.G., PCR-based screening and typing of Trypanosoma cruzi lineages directly from faecal samples of triatomine bugs from northwestern Argentina (2006) Parasitology, 132, pp. 1-9
  • Miles, M.A., Yeo, M., Gaunt, M., Genetic diversity of Trypanosoma cruzi and the epidemiology of Chagas disease (2003) Molecular Mechanisms in the Pathogenesis of Chagas Disease, pp. 1-15. , Kelly J.M. (Ed), Eurekah.com & Kluwer Academic/Plenum Publishers
  • Minter, D.M., 1976. Effects on transmission to man of the presence of domestic animals in infested households, In: Pan American Health Organization, New Approaches in American Trypanosomiasis Research. Washington, DC, Scientific Publication No. 318, 330-337; Montamat, E.E., Arauzo, S., Cazzulo, J.J., Subias, E., Characterization by electrophoretic zymograms of 19 Trypanosoma cruzi clones derived from two chronic chagasic patients (1987) Comp. Biochem. Physiol., 87, pp. 417-422
  • Montamat, E.E., De Luca d'Oro, G., Perret, B., Rivas, C., Characterization of Trypanosoma cruzi from Argentina by electrophoretic zymograms (1992) Acta Trop., 50, pp. 125-133
  • Montamat, E.E., De Luca d'Oro, G.M., Gallerano, R.H., Sosa, R., Blanco, A., Characterization of Trypanosoma cruzi populations by zymodemes: correlation with clinical picture (1996) Am. J. Trop. Med. Hyg., 55, pp. 625-628
  • Noireau, F., Flores, R., Gutierrez, T., Abad-Franch, F., Flores, E., Vargas, F., Natural ecotopes of Triatoma infestans dark morph and other sylvatic triatomines in the Bolivian Chaco (2000) Trans. R. Soc. Trop. Med. Hyg., 94, pp. 23-27
  • Rozas, M., Botto-Mahan, C., Coronado, X., Ortiz, S., Cattan, P.E., Solari, A., Coexistence of Trypanosoma cruzi genotypes in wild and periodomestic mammals in Chile (2007) Am. J. Trop. Med. Hyg., 77, pp. 647-653
  • Schijman, A.G., Altcheh, J., Burgos, J.M., Biancardi, M., Bisio, M., Levin, M., Freilij, H., Aetiological treatment of congenital Chagas disease diagnosed and monitored by the polymerase chain reaction (2003) J. Antimicrob. Chemother., 52, pp. 441-449
  • Schijman, A.G., Lauricella, M.A., Marcet, P.L., Duffy, T., Cardinal, M.V., Bisio, M., Levin, M.J., Gürtler, R.E., Differential detection of Blastocrithidia triatomae and Trypanosoma cruzi by amplification of 24s alpha ribosomal RNA genes in faeces of sylvatic triatomine species from rural northwestern Argentina (2006) Acta Trop., 99, pp. 50-54
  • Schweigmann, N.J., Pietrokovsky, S., Bottazzi, V., Conti, O., Bujas, M.A., Wisnivesky-Colli, C., Estudio de la prevalencia de infección por Trypanosoma cruzi en zarigüeyas (Didelphis albiventris) en Santiago del Estero, Argentina (1999) Rev. Panam. Salud Pública, 6, pp. 371-377
  • Telleria, J., Lafay, B., Virreira, M., Barnabé, C., Tibayrenc, M., Svoboda, M., Trypanosoma cruzi: sequence analysis of the variable region of kinetoplast minicircles (2006) Exp. Parasitol., 45, pp. 221-229
  • Tibayrenc, M., Genetic subdivisions within Trypanosoma cruzi (Discrete Typing Units) and their relevance for molecular epidemiology and experimental evolution (2003) Kinetoplastid Biol. Dis., 2, p. 12
  • Vazquez-Prokopec, G.M., Ceballos, L.A., Marcet, P.L., Cecere, M.C., Cardinal, M.V., Kitron, U., Gürtler, R.E., Seasonal variations in active dispersal of natural populations of Triatoma infestans in rural north-western Argentina (2006) Med. Vet. Entomol., 20, pp. 273-279
  • Wisnivesky-Colli, C., Schweigmann, N.J., Alberti, A., Pietrokovsky, S.M., Conti, O., Montoya, S., Riarte, A., Rivas, C., Sylvatic American trypanosomiasis in Argentina. Trypanosoma cruzi infection in mammals from the Chaco forest in Santiago del Estero (1992) Trans. R. Soc. Trop. Med. Hyg., 86, pp. 38-41
  • Yeo, M., Acosta, M., Llewellyn, M., Sánchez, H., Adamson, S., Miles, G., López, E., Miles, M.A., Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids (2005) Int. J. Parasitol., 35, pp. 225-233
  • Yeo, M., Lewis, M.D., Carrasco, H.J., Acosta, M., Llewellyn, M., da Silva Valente, S.A., de Costa Valente, V., Miles, M.A., Resolution of multiclonal infections of Trypanosoma cruzi from naturally infected triatomine bugs and from experimentally infected mice by direct plating on a sensitive solid medium (2007) Int. J. Parasitol., 37, pp. 111-120

Citas:

---------- APA ----------
Cardinal, M.V., Lauricella, M.A., Ceballos, L.A., Lanati, L., Marcet, P.L., Levin, M.J., Kitron, U.,..., Schijman, A.G. (2008) . Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina. International Journal for Parasitology, 38(13), 1533-1543.
http://dx.doi.org/10.1016/j.ijpara.2008.04.010
---------- CHICAGO ----------
Cardinal, M.V., Lauricella, M.A., Ceballos, L.A., Lanati, L., Marcet, P.L., Levin, M.J., et al. "Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina" . International Journal for Parasitology 38, no. 13 (2008) : 1533-1543.
http://dx.doi.org/10.1016/j.ijpara.2008.04.010
---------- MLA ----------
Cardinal, M.V., Lauricella, M.A., Ceballos, L.A., Lanati, L., Marcet, P.L., Levin, M.J., et al. "Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina" . International Journal for Parasitology, vol. 38, no. 13, 2008, pp. 1533-1543.
http://dx.doi.org/10.1016/j.ijpara.2008.04.010
---------- VANCOUVER ----------
Cardinal, M.V., Lauricella, M.A., Ceballos, L.A., Lanati, L., Marcet, P.L., Levin, M.J., et al. Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina. Int. J. Parasitol. 2008;38(13):1533-1543.
http://dx.doi.org/10.1016/j.ijpara.2008.04.010