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Abstract:

The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index.

Registro:

Documento: Artículo
Título:Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation
Autor:Trujillo, V.; Masseroni, M.L.; Levin, G.; Surez, M.M.
Filiación:Facultad de Ciencias Exactas, Fsicas y Naturales, Universidad Nacional de Crdoba, Crdoba, Argentina
Centro de Investigaciones Endocrinolgicas (CEDIE-CONICET), Hospital de Nios R. Gutirrez, Buenos Aires, Argentina
Idioma: Inglés
Palabras clave:Anxiety; Catecholamines; Early maternal separation; Plus maze; Tianeptine; Variable chronic stress; adrenalin; noradrenalin; tianeptine; adrenalin blood level; animal experiment; anxiety; article; catecholamine blood level; chronic stress; controlled study; high performance liquid chromatography; low drug dose; male; maternal deprivation; maze test; nonhuman; noradrenalin blood level; rat; Adrenal Cortex Hormones; Adrenal Medulla; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Anxiety; Anxiety, Separation; Behavior, Animal; Catecholamines; Chronic Disease; Female; Male; Maternal Deprivation; Rats; Rats, Wistar; Stress, Psychological; Thiazepines
Año:2009
Volumen:119
Número:8
Página de inicio:1210
Página de fin:1227
DOI: http://dx.doi.org/10.1080/00207450802324713
Título revista:International Journal of Neuroscience
Título revista abreviado:Int. J. Neurosci.
ISSN:00207454
CODEN:IJNUB
CAS:adrenalin, 51-43-4, 55-31-2, 6912-68-1; noradrenalin, 1407-84-7, 51-41-2; tianeptine, 66981-73-5; Adrenal Cortex Hormones; Antidepressive Agents, Tricyclic; Catecholamines; Thiazepines; tianeptine, 66981-73-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00207454_v119_n8_p1210_Trujillo

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Citas:

---------- APA ----------
Trujillo, V., Masseroni, M.L., Levin, G. & Surez, M.M. (2009) . Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation. International Journal of Neuroscience, 119(8), 1210-1227.
http://dx.doi.org/10.1080/00207450802324713
---------- CHICAGO ----------
Trujillo, V., Masseroni, M.L., Levin, G., Surez, M.M. "Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation" . International Journal of Neuroscience 119, no. 8 (2009) : 1210-1227.
http://dx.doi.org/10.1080/00207450802324713
---------- MLA ----------
Trujillo, V., Masseroni, M.L., Levin, G., Surez, M.M. "Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation" . International Journal of Neuroscience, vol. 119, no. 8, 2009, pp. 1210-1227.
http://dx.doi.org/10.1080/00207450802324713
---------- VANCOUVER ----------
Trujillo, V., Masseroni, M.L., Levin, G., Surez, M.M. Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation. Int. J. Neurosci. 2009;119(8):1210-1227.
http://dx.doi.org/10.1080/00207450802324713