Artículo

Guerra, F.K.; Eijan, A.M.; Puricelli, L.; Alonso, D.F.; De Kier Joffé, E.B.; Kornblihtt, A.R.; Charreau, E.H.; Elizalde, P.V. "Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability" (1996) International Journal of Cancer. 65(6):812-820
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Abstract:

We studied the expression of insulin-like growth factors I (IGF-I) and II (IGF-II) and their receptors (IGF-R) in 2 related murine mammary adenocarcinoma in vivo lines, M3 and MM3 with different metastasizing ability. We further investigated the effects of IGFs on the secretion of a key enzyme in the metastatic cascade, the urokinase-type plasminogen activator (uPA) in M3 and MM3 cells. M3 is a spontaneous mammary tumor originated in BALB/c mice, with a 40% incidence of lung metastases. MM3 variant, obtained by successive s.c. implants of M3 lung metastases into syngeneic mice, shows a 95% incidence of lung metastases. Similar levels of expression of IGF-I protein were found in M3 and MM3 tumors, whereas IGF-II expression was 4-fold higher in MM3. RNAse protection assays showed similar levels of IGF-I mRNA in M3 and MM3 tumors and revealed a 4-fold increase in IGF-II transcripts in MM3 tumors compared with M3. Authentic IGF-I and II messages were also found in primary cultures of M3 and MM3 cells. IGF-I mRNA levels were similar in both cultures and, as described for solid tumors a 5-fold increase in IGF-II message was detected in MM3 cells. The presence of type I and mannose-6-phosphate (Man-6P)/type II IGF-R was demonstrated in both M3 and MM3 tumors. A 2-fold increase of type I IGF-R was detected in MM3 tumors compared with M3. Man-6P/ type II IGF-R levels were 2-fold lower in MM3 tumors than in M3. As observed in tumor membranes, type I IGF-R concentrations were higher and Man-6P/type II IGF-R lower in cultures of MM3 epithelial cells compared with MM3 cells. In addition, we found that IGF-I enhanced secreted uPA activity in both M3 and MM3 cells while IGF-II only stimulated uPA secretion in MM3 cells.

Registro:

Documento: Artículo
Título:Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability
Autor:Guerra, F.K.; Eijan, A.M.; Puricelli, L.; Alonso, D.F.; De Kier Joffé, E.B.; Kornblihtt, A.R.; Charreau, E.H.; Elizalde, P.V.
Filiación:Inst. de Biol. y Med. Experimental, Buenos Aires, Argentina
Inst. Invest. Ing. Genet. y Biol. M., Buenos Aires, Argentina
Inst. de Oncologí A.H. Roffo, Buenos Aires, Argentina
Inst. de Biol. y Med. Experimental, Obligado 2490, Buenos Aires 1428, Argentina
Palabras clave:somatomedin b; somatomedin c; somatomedin receptor; urokinase; animal experiment; animal model; article; breast adenocarcinoma; controlled study; female; gene expression; metastasis potential; mouse; nonhuman; priority journal; Adenocarcinoma; Animals; Cell Division; Female; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Receptor, IGF Type 1; Receptor, IGF Type 2; RNA, Messenger; Tumor Cells, Cultured; Urinary Plasminogen Activator
Año:1996
Volumen:65
Número:6
Página de inicio:812
Página de fin:820
DOI: http://dx.doi.org/10.1002/(SICI)1097-0215(19960315)65:6<812::AID-IJC18>3.0.CO;2-5
Título revista:International Journal of Cancer
Título revista abreviado:INT. J. CANCER
ISSN:00207136
CODEN:IJCNA
CAS:Insulin-Like Growth Factor I, 67763-96-6; Insulin-Like Growth Factor II, 67763-97-7; Receptor, IGF Type 1, EC 2.7.1.112; Receptor, IGF Type 2; RNA, Messenger; Urinary Plasminogen Activator, EC 3.4.21.73
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00207136_v65_n6_p812_Guerra

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Citas:

---------- APA ----------
Guerra, F.K., Eijan, A.M., Puricelli, L., Alonso, D.F., De Kier Joffé, E.B., Kornblihtt, A.R., Charreau, E.H.,..., Elizalde, P.V. (1996) . Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability. International Journal of Cancer, 65(6), 812-820.
http://dx.doi.org/10.1002/(SICI)1097-0215(19960315)65:6<812::AID-IJC18>3.0.CO;2-5
---------- CHICAGO ----------
Guerra, F.K., Eijan, A.M., Puricelli, L., Alonso, D.F., De Kier Joffé, E.B., Kornblihtt, A.R., et al. "Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability" . International Journal of Cancer 65, no. 6 (1996) : 812-820.
http://dx.doi.org/10.1002/(SICI)1097-0215(19960315)65:6<812::AID-IJC18>3.0.CO;2-5
---------- MLA ----------
Guerra, F.K., Eijan, A.M., Puricelli, L., Alonso, D.F., De Kier Joffé, E.B., Kornblihtt, A.R., et al. "Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability" . International Journal of Cancer, vol. 65, no. 6, 1996, pp. 812-820.
http://dx.doi.org/10.1002/(SICI)1097-0215(19960315)65:6<812::AID-IJC18>3.0.CO;2-5
---------- VANCOUVER ----------
Guerra, F.K., Eijan, A.M., Puricelli, L., Alonso, D.F., De Kier Joffé, E.B., Kornblihtt, A.R., et al. Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability. INT. J. CANCER. 1996;65(6):812-820.
http://dx.doi.org/10.1002/(SICI)1097-0215(19960315)65:6<812::AID-IJC18>3.0.CO;2-5