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Abstract:

1. 1. Taking into account available experimental data. a mechanism of action for aminolaevulinate dehydratase is proposed. 2. 2. Besides the formation of a Schiff base between the substrate and the enzyme, the existence of a minimal functional dimer necessary for activity is also considered, as well as certain characteristics of the type of interactions involved in the inter-subunit contact sites and the role of histidine residues in the transport of protons from and to the active center. © 1978.

Registro:

Documento: Artículo
Título:Delta aminolaevulinate dehydratase: its mechanism of action
Autor:Del C. Batlle, A.M.; Stella, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria Nunez, 1428 Buenos Aires, Argentina
Palabras clave:porphobilinogen synthase; nonbiological model; Histidine; Lysine; Macromolecular Systems; Models, Biological; Porphobilinogen; Porphobilinogen Synthase; Pyrroles; Sulfhydryl Compounds
Año:1978
Volumen:9
Número:12
Página de inicio:861
Página de fin:864
DOI: http://dx.doi.org/10.1016/0020-711X(78)90060-5
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:porphobilinogen synthase, 9036-37-7; Histidine, 71-00-1; Lysine, 56-87-1; Macromolecular Systems; Porphobilinogen Synthase, EC 4.2.1.24; Porphobilinogen, 487-90-1; Pyrroles; Sulfhydryl Compounds
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v9_n12_p861_DelCBatlle

Referencias:

  • Batlle, Del, Ferramola, Grinstein, Purification and general properties of delta aminolaevulic dehvdratase from cow liver (1967) Biochem. J., 104, pp. 244-249
  • Batlle, del, Ferramola, Grinstein, Delta aminolaevulinate dehydratase (cow liver) (1970) Methods in Enzymology, 17, pp. 216-220. , H. Tabor, C. Tabor, Academic Press, New York, Part A
  • Batlle, Del, Stella, Ferramola, Sopena, Wider De, Sancovich, Porphyrin biosynthesis—immobilized enzymes and ligands—X. A novel approach to the study of the relationship between the quaternary structure of aminolaevulinate dehydratase and its activity (1978) International Journal of Biochemistry, 9, pp. 401-406
  • Chech, Neilands, Zinc, an essential metal ion for beef liver δ-aminolevulinate dehydratase (1973) Biochemical and Biophysical Research Communications, 55, pp. 1060-1063
  • Nandi, Shemin, Delta aminolevulinic acid dehydratase of Rh. spheroides III. Mechanism of porpho-bilinogen synthesis (1968) J. biol. Chem, 243, pp. 1236-1242
  • Nandi, Baker-Cohen, Shemin, Delta aminolevulinic acid dehydratase of Rh. spheroides I Isolation and mechanism (1968) J. biol. Chem., 243, pp. 1224-1230
  • Shemin, 5-Aminolaevulinic acid dehydratase: structure, function and mechanism (1976) Phil. Trans. R. Soc. Lond. B., 273, pp. 109-115
  • Tsukamoto, Yoshinaga, Sano, Evidence for histidine as another functional group of δ-aminolevulinic acid dehydratase from beef liver (1975) Biochem. biophys. Res. Commun., 67, pp. 294-300

Citas:

---------- APA ----------
Del C. Batlle, A.M. & Stella, A.M. (1978) . Delta aminolaevulinate dehydratase: its mechanism of action. International Journal of Biochemistry, 9(12), 861-864.
http://dx.doi.org/10.1016/0020-711X(78)90060-5
---------- CHICAGO ----------
Del C. Batlle, A.M., Stella, A.M. "Delta aminolaevulinate dehydratase: its mechanism of action" . International Journal of Biochemistry 9, no. 12 (1978) : 861-864.
http://dx.doi.org/10.1016/0020-711X(78)90060-5
---------- MLA ----------
Del C. Batlle, A.M., Stella, A.M. "Delta aminolaevulinate dehydratase: its mechanism of action" . International Journal of Biochemistry, vol. 9, no. 12, 1978, pp. 861-864.
http://dx.doi.org/10.1016/0020-711X(78)90060-5
---------- VANCOUVER ----------
Del C. Batlle, A.M., Stella, A.M. Delta aminolaevulinate dehydratase: its mechanism of action. Int. J. Biochem. 1978;9(12):861-864.
http://dx.doi.org/10.1016/0020-711X(78)90060-5