Artículo

Moretti, M.B.; García, S.C.; Stella, C.; Ramos, E.; Batlle, A.M.d.C. "δ-Aminolevulinic acid transport in Saccharomyces cerevisiae" (1993) International Journal of Biochemistry. 25(12):1917-1924
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Abstract:

1. 1. This work represents the first approach to characterize the transport system of haem pathway precursors, such as δ-aminolevulinic acid (ALA), in two strains of Saccharomyces cerevisiae, a wild type, D27, and a HEM R+ mutant. 2. 2. ALA transport occurs unidirectionally by a sole active system with an apparent KM of 0.10 mM, at the optimum pH of 5.0. ALA uptake is influenced by both the carbon and nitrogen source; this suggests a rather complex regulation mechanism. 3. 3. This transport is not mediated by the general amino acid permease (GAP). 4. 4. ALA uptake is strongly inhibited by compounds harboring a methyl-amine terminus suggesting that this group is essential for ALA transport; however, the electric environment of the carboxylic group may be also important for the interaction between ALA and its transporter active site. 5. 5. We have found differences in ALA transport which would indicate a different regulation mechanism for this system in both strain cells. © 1993.

Registro:

Documento: Artículo
Título:δ-Aminolevulinic acid transport in Saccharomyces cerevisiae
Autor:Moretti, M.B.; García, S.C.; Stella, C.; Ramos, E.; Batlle, A.M.d.C.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET, F.C.E. y N., UBA), Ciudad Universitaria, Pabellon II, 2o Piso, 1428 Buenos Aires, Argentina
Departamento de Bioquímica (CONICET, Facultad de Medicina, UBA), Paraguay 2155, 5o Piso, 1121 Buenos Aires, Argentina
Palabras clave:Saccharomyces cerevisiae; Saccharomyces cerevisiae; aminolevulinic acid; article; nonhuman; Saccharomyces cerevisiae; transport kinetics
Año:1993
Volumen:25
Número:12
Página de inicio:1917
Página de fin:1924
DOI: http://dx.doi.org/10.1016/0020-711X(88)90325-4
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:aminolevulinic acid, 106-60-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v25_n12_p1917_Moretti

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Citas:

---------- APA ----------
Moretti, M.B., García, S.C., Stella, C., Ramos, E. & Batlle, A.M.d.C. (1993) . δ-Aminolevulinic acid transport in Saccharomyces cerevisiae. International Journal of Biochemistry, 25(12), 1917-1924.
http://dx.doi.org/10.1016/0020-711X(88)90325-4
---------- CHICAGO ----------
Moretti, M.B., García, S.C., Stella, C., Ramos, E., Batlle, A.M.d.C. "δ-Aminolevulinic acid transport in Saccharomyces cerevisiae" . International Journal of Biochemistry 25, no. 12 (1993) : 1917-1924.
http://dx.doi.org/10.1016/0020-711X(88)90325-4
---------- MLA ----------
Moretti, M.B., García, S.C., Stella, C., Ramos, E., Batlle, A.M.d.C. "δ-Aminolevulinic acid transport in Saccharomyces cerevisiae" . International Journal of Biochemistry, vol. 25, no. 12, 1993, pp. 1917-1924.
http://dx.doi.org/10.1016/0020-711X(88)90325-4
---------- VANCOUVER ----------
Moretti, M.B., García, S.C., Stella, C., Ramos, E., Batlle, A.M.d.C. δ-Aminolevulinic acid transport in Saccharomyces cerevisiae. Int. J. Biochem. 1993;25(12):1917-1924.
http://dx.doi.org/10.1016/0020-711X(88)90325-4