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Abstract:

1. 1. The action of hexachlorobenzene (HCB) on hepatic ferrochelatase was investigated. 2. 2. A direct action of HCB, pentachlorophenol, porphyrins and haem on this enzyme activity was discarded. 3. 3. In HCB porphyric liver there is probably an activator tightly bound to the enzyme. 4. 4. Pyridoxal phosphate (PPL) may be a cofactor of ferrochelatase from both normal and porphyric rats. 5. 5. The PPL would be involved in the binding site of Fe2+ or at least in the approaching of Fe2+ to the active site of the enzyme. 6. 6. The differences found between normal and porphyric preparations could be attributed to conformational changes elicited by the HCB. © 1991.

Registro:

Documento: Artículo
Título:Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action
Autor:Ríos De Molina, M.D.C.; De Catabbi, S.B.; De Viale, L.C.S.M.
Filiación:Laboratories de Porfirias Experimentales y Metabolismo del Hemo, Departamento de Química Biologica, Faculted de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Núñez, 1428, Buenos Aires, Argentina [Tel. 782-0458]
Palabras clave:ferrochelatase; hexachlorobenzene; pyridoxal 5 phosphate; animal experiment; animal model; animal tissue; article; conformational transition; drug mechanism; drug toxicity; liver; nonhuman; oral drug administration; porphyria; rat; Animal; Binding Sites; Chromatography, Gel; Copper; Copper Sulfate; Female; Ferrochelatase; Heat; Heme; Hexachlorobenzene; Liver; Pentachlorophenol; Porphyria; Porphyrins; Protein Conformation; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Spectrophotometry; Support, Non-U.S. Gov't; Animalia
Año:1991
Volumen:23
Número:7-8
Página de inicio:669
Página de fin:673
DOI: http://dx.doi.org/10.1016/0020-711X(91)90036-M
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:Copper Sulfate, 7758-98-7; Copper, 7440-50-8; Ferrochelatase, EC 4.99.1.1; Heme, 14875-96-8; Hexachlorobenzene, 118-74-1; Pentachlorophenol, 87-86-5; Porphyrins; Pyridoxal Phosphate, 54-47-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v23_n7-8_p669_RiosDeMolina

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Citas:

---------- APA ----------
Ríos De Molina, M.D.C., De Catabbi, S.B. & De Viale, L.C.S.M. (1991) . Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action. International Journal of Biochemistry, 23(7-8), 669-673.
http://dx.doi.org/10.1016/0020-711X(91)90036-M
---------- CHICAGO ----------
Ríos De Molina, M.D.C., De Catabbi, S.B., De Viale, L.C.S.M. "Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action" . International Journal of Biochemistry 23, no. 7-8 (1991) : 669-673.
http://dx.doi.org/10.1016/0020-711X(91)90036-M
---------- MLA ----------
Ríos De Molina, M.D.C., De Catabbi, S.B., De Viale, L.C.S.M. "Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action" . International Journal of Biochemistry, vol. 23, no. 7-8, 1991, pp. 669-673.
http://dx.doi.org/10.1016/0020-711X(91)90036-M
---------- VANCOUVER ----------
Ríos De Molina, M.D.C., De Catabbi, S.B., De Viale, L.C.S.M. Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. mechanism of drug action. Int. J. Biochem. 1991;23(7-8):669-673.
http://dx.doi.org/10.1016/0020-711X(91)90036-M