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Abstract:

1. 1. Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of δ-aminolevulinate synthetase (ALA-S), cytochrome P-450 (cyt P-450) and cytochrome oxidase were determined in tumor (T) and liver of both normal mice (NM) and T bearing mice (TBM). 2. 2. Basal levels of ALA-S were nearly the same in either source. The amount of cyt P-450 was lower in TBM liver than in NM liver, and no detectable in T. While the basal activity of cytochrome oxidase in TBM liver and T were higher than those of NM liver. 3. 3. In AIA intoxicated animals there was a lower induction of ALA-S in liver of TBM than in NM liver. There was no induction in T ALA-S. The loss of cyt P-450 was less in TBM liver when compared with NM liver. 4. 4. The induction level of cyt P-450 after veronal administration was nearly the same in liver of both TBM and NM. 5. 5. We conclude that lower induction of liver ALA-S activity in TBM liver is due to correspondingly lower drug metabolism ability of TBM liver. Otherwise our results suggest that the control mechanism operating in T and probably in its original tissue are different from those described for normal liver. © 1990.

Registro:

Documento: Artículo
Título:Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase
Autor:Navone, N.M.; Polo, C.F.; Dinger, R.M.; Del C. Batlle, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) (CONICET, FCEN, DBA), Ciudad Universitaria, Pabellon 11, 2do Piso, 1428 Buenos Aires, Republica Argentina
Palabras clave:5 aminolevulinate synthase; allylisopropylacetamide; barbital; cytochrome c oxidase; cytochrome p450; animal cell; article; breast cancer; liver; mouse; nonhuman; 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animal; Barbital; Cytochrome P-450 Enzyme System; Cytochrome-c Oxidase; Enzyme Induction; Heme; Liver; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Support, Non-U.S. Gov't; Animalia
Año:1990
Volumen:22
Número:9
Página de inicio:1005
Página de fin:1008
DOI: http://dx.doi.org/10.1016/0020-711X(90)90207-J
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Allylisopropylacetamide, 299-78-5; Barbital, 57-44-3; Cytochrome P-450 Enzyme System, 9035-51-2; Cytochrome-c Oxidase, EC 1.9.3.1; Heme, 14875-96-8
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_0020711X_v22_n9_p1005_Navone.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v22_n9_p1005_Navone

Referencias:

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Citas:

---------- APA ----------
Navone, N.M., Polo, C.F., Dinger, R.M. & Del C. Batlle, A.M. (1990) . Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase. International Journal of Biochemistry, 22(9), 1005-1008.
http://dx.doi.org/10.1016/0020-711X(90)90207-J
---------- CHICAGO ----------
Navone, N.M., Polo, C.F., Dinger, R.M., Del C. Batlle, A.M. "Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase" . International Journal of Biochemistry 22, no. 9 (1990) : 1005-1008.
http://dx.doi.org/10.1016/0020-711X(90)90207-J
---------- MLA ----------
Navone, N.M., Polo, C.F., Dinger, R.M., Del C. Batlle, A.M. "Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase" . International Journal of Biochemistry, vol. 22, no. 9, 1990, pp. 1005-1008.
http://dx.doi.org/10.1016/0020-711X(90)90207-J
---------- VANCOUVER ----------
Navone, N.M., Polo, C.F., Dinger, R.M., Del C. Batlle, A.M. Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase. Int. J. Biochem. 1990;22(9):1005-1008.
http://dx.doi.org/10.1016/0020-711X(90)90207-J