Abstract:
1. 1. Porphyrin biosynthesis from 5-aminoevulinic acid (ALA) was investigated using the technique of tissue explant cultures, in both human breast cancer and its original normal tissue. 2. 2. The activity of ALA-dehydratase, porphobilinogenase and uroporphyrinogen decarboxylase was directly determined in both tumor and normal mammary tissues. 3. 3. Porphyrin synthesis capacity of human breast carcinoma was 20-fold enhanced, as compared with normal tissue, at least between the stages of porphobilinogen and coproporphyrinogen formation. 4. 4. The activity of the three enzymes examined was always lower in normal tissue than in tumoral tissue. 5. 5. Present findings show that porphyrin biosynthesis is increased in breast cancer tissue. © 1990.
Registro:
Documento: |
Artículo
|
Título: | Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels |
Autor: | Navone, N.M.; Polo, C.F.; Frisardi, A.L.; Andrade, N.E.; del C. Baille, a.M. |
Filiación: | Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) (CONICET-FCEN, UBA), Ciudad Universitaria, Pabellon 11, 2 do Piso, 1428 Buenos Aires, Argentina Instituto Nacional de Oncología Angel H. Roffo, Avda San Martin 5481, 1417 Buenos Aires, Argentina
|
Palabras clave: | porphobilinogen synthase; porphyrin; article; breast cancer; explant; heme synthesis; histology; human; human cell; priority journal; Adult; Aged; Ammonia-Lyases; Breast; Breast Neoplasms; Female; Heme; Human; Middle Age; Porphobilinogen Synthase; Support, Non-U.S. Gov't; Tissue Culture; Uroporphyrinogen Decarboxylase |
Año: | 1990
|
Volumen: | 22
|
Número: | 12
|
Página de inicio: | 1407
|
Página de fin: | 1411
|
DOI: |
http://dx.doi.org/10.1016/0020-711X(90)90230-Z |
Título revista: | International Journal of Biochemistry
|
Título revista abreviado: | Int. J. Biochem.
|
ISSN: | 0020711X
|
CODEN: | IJBOB
|
CAS: | Ammonia-Lyases, EC 4.3.1.; Heme, 14875-96-8; Porphobilinogen Synthase, EC 4.2.1.24; porphobilinogenase, EC 5.-; Uroporphyrinogen Decarboxylase, EC 4.1.1.37
|
PDF: | https://bibliotecadigital.exactas.uba.ar/download/paper/paper_0020711X_v22_n12_p1407_Navone.pdf |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v22_n12_p1407_Navone |
Referencias:
- Batlle, Ferramola, Orinstein, Purification and general properties of δ-aminolevulinate dehydratase from cow liver (1967) Biochem. J., 194, pp. 244-249
- Batlle, Wider de Xifra, Stella, A simple method for measuring erythrocyte porphobilinogenase and its use in the diagnosis of acute intermittent porphyria (1978) International Journal of Biochemistry, 9, pp. 871-875
- Bonkowsky, Tschudy, Collins, Doherty, Control of 5-aminolevulinic acid synthetase and tyrosine aminotransferase in tumors and livers of tumorbearing rats (1973) J. natn. Cancer Inst., 50, pp. 1215-1225
- Bugelski, Poter, Dougherty, Autoradiographic distribution of hematoporphyrin derivatives in normal and tumor tissue of the mouse (1981) Cancer Res, 41, pp. 4606-4612
- Buzaleh, Afonso, Polo, Navone, Bianchi, Schoua, Batlle, Vazquez, Induction of porphyrin biosynthesis in the non-animal model of tissue expiant cultures: prevention and reversal by the antimitotic colchicine (1988) ATLA, 16, pp. 137-144
- Denk, Abdelfattah-Gad, Eckerstorfer, Talcott, Microsomal mixed-function oxidase and activities of some related enzymes in hyperplastic nodules induced by long-term griseofulvin administration in mouse liver (1980) Cancer Res., 40, pp. 2568-2573
- Dougherty, Kaufman, Goldfarb, Weishaupt, Boyle, Mittelman, Photoradiation therapy for the treatment of malignant tumors (1978) Cancer Res., 38, pp. 2628-2635
- Dougherty, Lawrence, Kaufman, Boyle, Weishaupt, Goldfarb, Photoradiation in the treatment of recurrent breast carcinoma (1979) J. natn. Cancer Inst., 62, pp. 231-237
- Farber, Cellular biochemistry of the stepwise development of cancer with chemicals. GHA Clowes Memorial Lecture (1984) Cancer Res., 44, pp. 5463-5474
- Gomer, Dougherty, Determination of 3H- and 14C-hematoporphyrin derivative distribution in malignant and normal tissue (1979) Cancer Res., 39, pp. 146-151
- Gregorie, Horger, Ward, Green, Richards, Robertson, Stevenson, Hematoporphyrin derivative fluorescence in malignant neoplasms (1968) Ann. Surg, 167, pp. 820-828
- Jori, Reddi, Cozzani, Tomio, Controlled targeting of different subcellular sites by protoporphyrins in tumor-bearing mice (1986) Br, J. Cancer, 53, pp. 615-621
- Kessel, Transport and binding of hematoporphyrin derivative and related porphyrins by murine leukemia L 1210 cells (1981) Cancer Res., 41, pp. 1318-1323
- Lahav, Epstein, Schoenfeld, Shaklai, Atsmon, Increased porphobilinogen deaminase activity in patients with malignant lymphoproliferative diseases (1987) J. Am. Med. Assoc., 257, pp. 39-42
- Lipson, Baldes, Olsen, The use of derivative of hematoporphyrin in tumor detection (1961) J. naln. Cancer Inst., 26, pp. 1-12
- Lowry, Rosebrough, Farr, Randall, Protein measurement with the folin phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
- Navone, Frisardi, Resnik, Batlle, Polo, Porphyrin biosynthesis in human breast cancer. Preliminary mimetic in vitro studies (1988) Med. Sci. Res., 16, pp. 61-62
- Navone, Polo, Dinger, Batlle, Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice. 1. Effect of allylisopropylacetamide and veronal on °5-aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase (1990) Int. J. Biochem., 22, pp. 1005-1008
- Polo, Frisardi, Resnik, Shoua, Batlle, Factors influencing fluorescence spectra of free porphyrins (1988) Clin. Chem., 34, pp. 757-760
- Polo, Navone, Cirigliano, Garro, Rossetti, Wider, Un método para la medición de la actividad enzimática de la uroporfirinógeno decarboxilasa en sangre (1990) Acta Bioquim. Clin. Latinoamer., , (in press)
- Rasetti, Rubino, Drago, Ferrochelatase, ALA-dehydrase and ALA-synthetase activity in human tumor disease (1967) PanMinerva Med., 8, pp. 132-135
- Rassrnussen-Taxdall, Ward, Figge, Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrin (1955) Cancer, 8, pp. 78-81
- Sandberg, Romslo, Porphyrin-induced photodamage at the cellular and subcellular level as related to the solubility of the porphyrin (1981) Clinica chim. acta, 109, pp. 193-201
- Stout, Becker, Heme enzyme patterns in genetically and chemically induced mouse liver tumors (1986) Cancer Res., 46, pp. 2756-2759
- Stout, Becker, Heme enzyme patterns in rat liver nodules and tumors (1987) Cancer Res., 47, pp. 963-966
- Takaku, Wada, Heme synthesis in normal and leukemic leukocytes (1968) Cancer Res., 28, pp. 1250-1255
- Vázquez, Buzaleh, Navone, Polo, Schoua, Afonso, Batlle, Cultivo de explantes tisulares. II. Grado de lisis y su protección por el ácido δ-aminolevúlico (1986) An. Med. Inter. (Madrid), 111, pp. 258-262
- Vázquez, Afonso, Buzaleh, Navone, Polo, Schoua, Batlle, The effect of griseofulvin on heme pathway. Studies on tissue explant cultures (1987) Toxicology, 46, pp. 73-82
Citas:
---------- APA ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Andrade, N.E. & del C. Baille, a.M.
(1990)
. Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels. International Journal of Biochemistry, 22(12), 1407-1411.
http://dx.doi.org/10.1016/0020-711X(90)90230-Z---------- CHICAGO ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Andrade, N.E., del C. Baille, a.M.
"Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels"
. International Journal of Biochemistry 22, no. 12
(1990) : 1407-1411.
http://dx.doi.org/10.1016/0020-711X(90)90230-Z---------- MLA ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Andrade, N.E., del C. Baille, a.M.
"Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels"
. International Journal of Biochemistry, vol. 22, no. 12, 1990, pp. 1407-1411.
http://dx.doi.org/10.1016/0020-711X(90)90230-Z---------- VANCOUVER ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Andrade, N.E., del C. Baille, a.M. Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels. Int. J. Biochem. 1990;22(12):1407-1411.
http://dx.doi.org/10.1016/0020-711X(90)90230-Z