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Abstract:

1. 1. Porphyrin biosynthesis from 5-aminoevulinic acid (ALA) was investigated using the technique of tissue explant cultures, in both human breast cancer and its original normal tissue. 2. 2. The activity of ALA-dehydratase, porphobilinogenase and uroporphyrinogen decarboxylase was directly determined in both tumor and normal mammary tissues. 3. 3. Porphyrin synthesis capacity of human breast carcinoma was 20-fold enhanced, as compared with normal tissue, at least between the stages of porphobilinogen and coproporphyrinogen formation. 4. 4. The activity of the three enzymes examined was always lower in normal tissue than in tumoral tissue. 5. 5. Present findings show that porphyrin biosynthesis is increased in breast cancer tissue. © 1990.

Registro:

Documento: Artículo
Título:Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels
Autor:Navone, N.M.; Polo, C.F.; Frisardi, A.L.; Andrade, N.E.; del C. Baille, a.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) (CONICET-FCEN, UBA), Ciudad Universitaria, Pabellon 11, 2 do Piso, 1428 Buenos Aires, Argentina
Instituto Nacional de Oncología Angel H. Roffo, Avda San Martin 5481, 1417 Buenos Aires, Argentina
Palabras clave:porphobilinogen synthase; porphyrin; article; breast cancer; explant; heme synthesis; histology; human; human cell; priority journal; Adult; Aged; Ammonia-Lyases; Breast; Breast Neoplasms; Female; Heme; Human; Middle Age; Porphobilinogen Synthase; Support, Non-U.S. Gov't; Tissue Culture; Uroporphyrinogen Decarboxylase
Año:1990
Volumen:22
Número:12
Página de inicio:1407
Página de fin:1411
DOI: http://dx.doi.org/10.1016/0020-711X(90)90230-Z
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:Ammonia-Lyases, EC 4.3.1.; Heme, 14875-96-8; Porphobilinogen Synthase, EC 4.2.1.24; porphobilinogenase, EC 5.-; Uroporphyrinogen Decarboxylase, EC 4.1.1.37
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_0020711X_v22_n12_p1407_Navone.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v22_n12_p1407_Navone

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Citas:

---------- APA ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Andrade, N.E. & del C. Baille, a.M. (1990) . Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels. International Journal of Biochemistry, 22(12), 1407-1411.
http://dx.doi.org/10.1016/0020-711X(90)90230-Z
---------- CHICAGO ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Andrade, N.E., del C. Baille, a.M. "Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels" . International Journal of Biochemistry 22, no. 12 (1990) : 1407-1411.
http://dx.doi.org/10.1016/0020-711X(90)90230-Z
---------- MLA ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Andrade, N.E., del C. Baille, a.M. "Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels" . International Journal of Biochemistry, vol. 22, no. 12, 1990, pp. 1407-1411.
http://dx.doi.org/10.1016/0020-711X(90)90230-Z
---------- VANCOUVER ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Andrade, N.E., del C. Baille, a.M. Heme biosynthesis in human breast cancer-mimetic "in vitro" studies and some heme enzymic activity levels. Int. J. Biochem. 1990;22(12):1407-1411.
http://dx.doi.org/10.1016/0020-711X(90)90230-Z