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Abstract:

1. 1. The kinetic properties of the p-nitrophenylphosphatase (EC 3.1.3.1) from erythrocytes was investigated in DMD-patients and DMD-carriers. 2. 2. A different allosteric behaviour in the p-nitrophenylphosphatase from DMD-patients and DMD-carriers compared to controls is supported by the following finclings: (a) values of n altered in F- inhibition of (K+-activated p-nitrophenylphosphatase with Hill coefficients -1.5, -2.2 and -3.1; (b) heterotropic effect of increased concentration of Mg2+ on F- inhibition which is reverted by K+ in DMD-carriers and in control, but not in DMD-patients. 3. 3. Evidence is presented showing that in DMD-patients and in DMD-carriers the interaction membrane-enzyme is different from the corresponcling controls. © 1988.

Registro:

Documento: Artículo
Título:Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)
Autor:Goldemberg, A.L.; García, A.M.; Fernández, H.; Fortunato, M.; Sánchez, J.J.; Trucco, R.E.
Filiación:Facultad de Ciencias Exactas y Naturales, U.N. de Mar del Plata, Funes 3250, 7600 Mar del Plata, Argentina
Instituto National de Tecnología Industrial, Centro de Investigaciones de Tecnología Pesquera, Marcelo T. de Alvear 1168, 7600 Mar del PlataArgentina
Departamento de Enfermedades Neuromusculares, Hospital de Ninos Ricardo Gutiérrez, Gallo, 1330 Buenos Aires, Argentina
Palabras clave:alkaline phosphatase; allosterism; case report; duchenne muscular dystrophy; erythrocyte; heterozygote; human; human cell; 4-Nitrophenylphosphatase; Alkaline Phosphatase; Allosteric Regulation; Erythrocyte Membrane; Female; Fluorides; Heterozygote; Human; In Vitro; Kinetics; Magnesium; Male; Muscular Dystrophies; Phosphoric Monoester Hydrolases; Support, Non-U.S. Gov't
Año:1988
Volumen:20
Número:7
Página de inicio:703
Página de fin:706
DOI: http://dx.doi.org/10.1016/0020-711X(88)90165-6
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:alkaline phosphatase, 9001-78-9; 4-Nitrophenylphosphatase, EC 3.1.3.41; Alkaline Phosphatase, EC 3.1.3.1; Fluorides; Magnesium, 7439-95-4; Phosphoric Monoester Hydrolases, EC 3.1.3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v20_n7_p703_Goldemberg

Referencias:

  • Dodge, Mitchell, Hananhan, The preparation and chemical characteristic of hemoglobin-free ghosts of human erythrocytes (1963) Archs Biochem. Biophys., 100, pp. 119-130
  • Dun, Burghes, Dubowitz, Erythrocyte ghost Na+, K+-adenosine triphosphatase in Duchenne muscular dystrophy (1980) J. neurol. Sci., 46, pp. 209-213
  • Farías, Goldemberg, Trucco, The effect of fat deprivation on the allosteric inhibition by fluoride of the (Mg2+-ATPase and (Na+ + K+)-ATPase from rat erythrocytes (1970) Archives of Biochemistry and Biophysics, 139, pp. 38-44
  • Farias, Bloj, Morero, Siñeríz, Trucco, Regulation of allosteric membrane-bound enzymes through changes in membrane lipid composition (1975) Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 415, pp. 231-251
  • Farias, Membrane cooperative enzymes as a tool for the investigation of membrane structure and related phenomena (1980) Adv. Lipid Res., 17, pp. 251-282
  • Frass, Toifl, Leixnering, Adenine metabolism in erythrocytes of patients with Duchenne Muscular Dystrophy (1983) Eur. Neurol., 22, pp. 380-384
  • Garrahan, Pouchan, Rega, Potassium activated phosphatase from human red blood cells. The mechanism of potassium activation (1969) J. Physiol., Lond., 202, pp. 305-327
  • Goldemberg, Farias, Trucco, Allosteric changes of p-nitrophenylphosphatase from rat erythrocytes in fat deficiency (1972) J. biol. Chem., 247, pp. 4299-4304
  • Goldemberg, Casaro, Quiroga, Trucco, Alkaline phosphatase inhibition in copper-deficient and copper-sufficient cattle (Bos taurus) (1985) Comp. Biochem. Physiol., 81 B, pp. 535-537
  • Goldemberg, Sánchez, Garcia, Trucco, Fernández, Fortunato, Alkaline phosphatase of red blood cells in muscular dystrophy (1986) Medicina, B. Aires, 46, pp. 476-477
  • Kuby, Hamada, Nesset, Tyler, Ziter, Some enzymic studies on human Duchenne muscular dystrophy (1983) Biochemistry of Metabolic Processes, pp. 303-322. , D.L.F. Lennon, F.W. Stratman, R.N. Zahiten, Elsevier, New York
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Lyon, Sex chromatin and gene action in the mammalian X-chromosome (1962) Am. J. Hum. Genet., 14, pp. 135-148
  • Mawatari, Schonberg, Olarte, Biochemical abnormalities of erythrocyte membranes in Duchenne dystrophy. Adenosine triphosphatase and adenyl cyclase (1976) Archs Neurol., 33, pp. 489-493
  • Morero, Bloj, Farías, Trucco, The allosteric transitions from membrane-bound enzymes: behavior of erythrocyte acetylcholinesterase from fat-deficient rats (1972) Biochim. biophys. Acta, 282, pp. 157-165
  • Peter, Worstold, Pearson, Erythrocyte ghost adenosine triphosphatase (ATPase) in Duchenne dystrophy (1969) J. Lab. clin. Med., 74, pp. 103-107

Citas:

---------- APA ----------
Goldemberg, A.L., García, A.M., Fernández, H., Fortunato, M., Sánchez, J.J. & Trucco, R.E. (1988) . Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens). International Journal of Biochemistry, 20(7), 703-706.
http://dx.doi.org/10.1016/0020-711X(88)90165-6
---------- CHICAGO ----------
Goldemberg, A.L., García, A.M., Fernández, H., Fortunato, M., Sánchez, J.J., Trucco, R.E. "Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)" . International Journal of Biochemistry 20, no. 7 (1988) : 703-706.
http://dx.doi.org/10.1016/0020-711X(88)90165-6
---------- MLA ----------
Goldemberg, A.L., García, A.M., Fernández, H., Fortunato, M., Sánchez, J.J., Trucco, R.E. "Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)" . International Journal of Biochemistry, vol. 20, no. 7, 1988, pp. 703-706.
http://dx.doi.org/10.1016/0020-711X(88)90165-6
---------- VANCOUVER ----------
Goldemberg, A.L., García, A.M., Fernández, H., Fortunato, M., Sánchez, J.J., Trucco, R.E. Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens). Int. J. Biochem. 1988;20(7):703-706.
http://dx.doi.org/10.1016/0020-711X(88)90165-6