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Del C. Batlle, A.M.; Fukuda, H.; Parera, V.E.; Wider, E.; Stella, A.M. "In inherited porphyrias, lead intoxication is a toxogenetic disorder" (1987) International Journal of Biochemistry. 19(8):717-720
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Abstract:

1. 1. δ-Aminolevulinic acid dehydratase (ALA-D), blood lead and several enzymes and metabolites of the heme biosynthetic pathway were measured in a number of symptomatic porphyric patients, 22 with acute intermittent porphyria, three with hereditary hepatic coproporphyria, 10 with hereditary porphyria cutanea tarda, two with erythropoietic protoporphyria and two with congenital erythropoietic porphyria and in 84 lead intoxicated persons. 2. 2. In the 39 individuals suffering from the inherited porphyrias and in 32 lead poisoned patients with a 30-50% reduced deaminase, blood lead content was not sufficiently increased (average 28 μg%) to account for the greatly decreased activity of ALA-D (average 36% of controls). 3. 3. After a relatively trifling lead exposure they developed the signs of acute lead intoxication. 4. 4. A second group of lead intoxicated patients showing low ALA-D activity and corresponding high concentration of lead in blood, exhibited no other physiologic deviation in the enzymes and metabolites of porphyrin biosynthesis. 5. 5. Individuals with inherited porphyrias are ultrasensitive to low level lead exposure and that lead would also act as a triggering factor. In these patients, lead intoxication can be considered a toxogenetic disorder. 6. 6. An inversely linear correlation between ALA-D activity and blood lead content was obtained for both groups of lead intoxicated patients, however, a different constant (k) for each was obtained, which we have taken as a measure of lead toxogeneticity: k = 10 ± 1 for lead intoxicated individuals with otherwise normal heme metabolism and k = 5 ± 0.5 for lead intoxicated symptomatic porphyric patients. 7. 7. Determination of erythrocytic ALA-D, besides blood lead, will be a valuable indicator for preventive medical care for these patients, when they are expected to be exposed to lead either environmentally or in their professional life. © 1987.

Registro:

Documento: Artículo
Título:In inherited porphyrias, lead intoxication is a toxogenetic disorder
Autor:Del C. Batlle, A.M.; Fukuda, H.; Parera, V.E.; Wider, E.; Stella, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET, y Facultad de Ciencias E, C. Universitaria, Pab. II, 1428 Buenos Aires, Argentina
Palabras clave:lead; porphobilinogen synthase; acute intermittent porphyria; blood; blood and hemopoietic system; congenital disorder; congenital erythropoietic porphyria; erythropoietic protoporphyria; etiology; human; intoxication; lead poisoning; porphyria; porphyria cutanea tarda; priority journal; review; Heme; Humans; Lead; Lead Poisoning; Porphobilinogen Synthase; Porphyrias
Año:1987
Volumen:19
Número:8
Página de inicio:717
Página de fin:720
DOI: http://dx.doi.org/10.1016/0020-711X(87)90086-3
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:lead, 13966-28-4, 7439-92-1; porphobilinogen synthase, 9036-37-7; Heme, 14875-96-8; Lead, 7439-92-1; Porphobilinogen Synthase, 4.2.1.24
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v19_n8_p717_DelCBatlle

Referencias:

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  • Batlle A.M. del, Wider de Xifra, Stella, A simple method for measuring erythrocyte porphobilinogenase and its use in the diagnosis of acute intermittent porphyria (1978) Int. J. Biochem., 9, pp. 871-875
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Citas:

---------- APA ----------
Del C. Batlle, A.M., Fukuda, H., Parera, V.E., Wider, E. & Stella, A.M. (1987) . In inherited porphyrias, lead intoxication is a toxogenetic disorder. International Journal of Biochemistry, 19(8), 717-720.
http://dx.doi.org/10.1016/0020-711X(87)90086-3
---------- CHICAGO ----------
Del C. Batlle, A.M., Fukuda, H., Parera, V.E., Wider, E., Stella, A.M. "In inherited porphyrias, lead intoxication is a toxogenetic disorder" . International Journal of Biochemistry 19, no. 8 (1987) : 717-720.
http://dx.doi.org/10.1016/0020-711X(87)90086-3
---------- MLA ----------
Del C. Batlle, A.M., Fukuda, H., Parera, V.E., Wider, E., Stella, A.M. "In inherited porphyrias, lead intoxication is a toxogenetic disorder" . International Journal of Biochemistry, vol. 19, no. 8, 1987, pp. 717-720.
http://dx.doi.org/10.1016/0020-711X(87)90086-3
---------- VANCOUVER ----------
Del C. Batlle, A.M., Fukuda, H., Parera, V.E., Wider, E., Stella, A.M. In inherited porphyrias, lead intoxication is a toxogenetic disorder. Int. J. Biochem. 1987;19(8):717-720.
http://dx.doi.org/10.1016/0020-711X(87)90086-3