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Abstract:

1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.

Registro:

Documento: Artículo
Título:Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
Autor:Rios de Molina del, M.C.; Wainstok de Calmanovici, R.; San Martin de Viale, L.C.
Filiación:Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez, 1428, Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez, 1428, Buenos Aires, Argentina
Palabras clave:hexachlorobenzene; uroporphyrinogen decarboxylase; animal model; liver; nonhuman; porphyria; rat; Animal; Carboxy-Lyases; Chlorobenzenes; Female; Hexachlorobenzene; Liver; Porphyria; Porphyrinogens; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Uroporphyrinogen Decarboxylase; Uroporphyrinogens
Año:1987
Volumen:19
Número:4
Página de inicio:365
Página de fin:372
DOI: http://dx.doi.org/10.1016/0020-711X(87)90010-3
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:hexachlorobenzene, 118-74-1, 55600-34-5; uroporphyrinogen decarboxylase, 9024-70-8; Carboxy-Lyases, EC 4.1.1.; Chlorobenzenes; Hexachlorobenzene, 118-74-1; Porphyrinogens; Uroporphyrinogen Decarboxylase, EC 4.1.1.37; Uroporphyrinogens
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_0020711X_v19_n4_p365_RiosdeMolinadel.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v19_n4_p365_RiosdeMolinadel

Referencias:

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Citas:

---------- APA ----------
Rios de Molina del, M.C., Wainstok de Calmanovici, R. & San Martin de Viale, L.C. (1987) . Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I. International Journal of Biochemistry, 19(4), 365-372.
http://dx.doi.org/10.1016/0020-711X(87)90010-3
---------- CHICAGO ----------
Rios de Molina del, M.C., Wainstok de Calmanovici, R., San Martin de Viale, L.C. "Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I" . International Journal of Biochemistry 19, no. 4 (1987) : 365-372.
http://dx.doi.org/10.1016/0020-711X(87)90010-3
---------- MLA ----------
Rios de Molina del, M.C., Wainstok de Calmanovici, R., San Martin de Viale, L.C. "Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I" . International Journal of Biochemistry, vol. 19, no. 4, 1987, pp. 365-372.
http://dx.doi.org/10.1016/0020-711X(87)90010-3
---------- VANCOUVER ----------
Rios de Molina del, M.C., Wainstok de Calmanovici, R., San Martin de Viale, L.C. Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I. Int. J. Biochem. 1987;19(4):365-372.
http://dx.doi.org/10.1016/0020-711X(87)90010-3