Abstract:
1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986.
Registro:
Documento: |
Artículo
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Título: | Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins |
Autor: | Del C. Batlle, A.M.; De Salamanca, R.E.; Chinarro, S.; Afonso, S.G.; Stella, A.M. |
Filiación: | Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET-FCEN, UBA) Pabellón II, Ciudad Universitaria, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina Unidad de Porfirias, Hospital Clinico San Carlos, Universidad Complutense de Madrid, Spain
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Palabras clave: | porphyrin; uroporphyrinogen decarboxylase; blood and hemopoietic system; enzyme inactivation; erythrocyte; human; human cell; photoactivation; Carboxy-Lyases; Erythrocytes; Humans; Kinetics; Photolysis; Porphyrins; Thermodynamics; Ultraviolet Rays; Uroporphyrinogen Decarboxylase |
Año: | 1986
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Volumen: | 18
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Número: | 2
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Página de inicio: | 143
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Página de fin: | 147
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DOI: |
http://dx.doi.org/10.1016/0020-711X(86)90146-1 |
Título revista: | International Journal of Biochemistry
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Título revista abreviado: | Int. J. Biochem.
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ISSN: | 0020711X
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CODEN: | IJBOB
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CAS: | porphyrin, 24869-67-8; uroporphyrinogen decarboxylase, 9024-70-8; Carboxy-Lyases, 4.1.1.-; Porphyrins; Uroporphyrinogen Decarboxylase, 4.1.1.37
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PDF: | https://bibliotecadigital.exactas.uba.ar/download/paper/paper_0020711X_v18_n2_p143_DelCBatlle.pdf |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v18_n2_p143_DelCBatlle |
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Citas:
---------- APA ----------
Del C. Batlle, A.M., De Salamanca, R.E., Chinarro, S., Afonso, S.G. & Stella, A.M.
(1986)
. Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins. International Journal of Biochemistry, 18(2), 143-147.
http://dx.doi.org/10.1016/0020-711X(86)90146-1---------- CHICAGO ----------
Del C. Batlle, A.M., De Salamanca, R.E., Chinarro, S., Afonso, S.G., Stella, A.M.
"Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins"
. International Journal of Biochemistry 18, no. 2
(1986) : 143-147.
http://dx.doi.org/10.1016/0020-711X(86)90146-1---------- MLA ----------
Del C. Batlle, A.M., De Salamanca, R.E., Chinarro, S., Afonso, S.G., Stella, A.M.
"Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins"
. International Journal of Biochemistry, vol. 18, no. 2, 1986, pp. 143-147.
http://dx.doi.org/10.1016/0020-711X(86)90146-1---------- VANCOUVER ----------
Del C. Batlle, A.M., De Salamanca, R.E., Chinarro, S., Afonso, S.G., Stella, A.M. Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins. Int. J. Biochem. 1986;18(2):143-147.
http://dx.doi.org/10.1016/0020-711X(86)90146-1