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Abstract:

1. 1. Five patients with chronic lead intoxication were treated with S-adenosyl-l-methionine (12 mg/kg body weight, daily), given intravenously, over a period of 22 days. 2. 2. A significant recovery of erythrocytic ALA-D was observed in all cases, after therapy. 3. 3. Blood lead content significantly pathologic at the beginning of SAM administration, rapidly decreased within 24-48 h of initiating treatment, reaching nearly control values at the end of the trial. 4. 4. A good correlation between recovery of ALA-D activity and decreased concentration of lead in RBC was found. 5. 5. GSH content in blood was diminished in lead poisoned patients, increasing to normal levels after SAM administration. 6. 6. Other biochemical parameters such as Deaminase activity in RBC, ALA, PBG, porphyrins and lead in urine and serum γ-GT were measured, showing no important deviations from control values before, during or after treatment. 7. 7. Both biochemical and clinical improvement was observed, indicating that SAM therapy is beneficial in the treatment of lead intoxication. No untoward signs were observed. 8. 8. The mechanism of action of SAM is not yet clear; however, a chelating effect could be excluded, and very likely its action can be attributed to glutathione availability. © 1985.

Registro:

Documento: Artículo
Título:Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy
Autor:Paredes, S.R.; de Geralnik, A.A.J.; Del C. Batlle, A.M.; Conti, H.A.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias CIPYP (Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET y Facultad de Ciencias Exactas y Naturales, Universidad de B. Aires, FCEN-UBA, C. Universitaria, Pab. II, 1428 Buenos Aires, Argentina
División B. Unidad 4, Clínica Médica, Hospital General de Agudos J.M. Ramos Mejía, Argentina
Palabras clave:glutathione; lead; porphobilinogen synthase; s adenosylmethionine; chelation; clinical article; drug therapy; human; intoxication; lead poisoning; therapy; Adult; Child; Child, Preschool; Erythrocytes; Female; gamma-Glutamyltransferase; Glutathione; Human; Hydroxymethylbilane Synthase; Lead; Lead Poisoning; Male; Porphobilinogen Synthase; Porphyrins; S-Adenosylmethionine; Support, Non-U.S. Gov't; Time Factors
Año:1985
Volumen:17
Número:5
Página de inicio:625
Página de fin:629
DOI: http://dx.doi.org/10.1016/0020-711X(85)90295-2
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:glutathione, 70-18-8; lead, 7439-92-1; porphobilinogen synthase, 9036-37-7; s adenosylmethionine, 29908-03-0, 485-80-3; gamma-Glutamyltransferase, EC 2.3.2.2; Glutathione, 70-18-8; Hydroxymethylbilane Synthase, EC 4.3.1.8; Lead, 7439-92-1; Porphobilinogen Synthase, EC 4.2.1.24; Porphyrins; S-Adenosylmethionine, 29908-03-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v17_n5_p625_Paredes

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Citas:

---------- APA ----------
Paredes, S.R., de Geralnik, A.A.J., Del C. Batlle, A.M. & Conti, H.A. (1985) . Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy. International Journal of Biochemistry, 17(5), 625-629.
http://dx.doi.org/10.1016/0020-711X(85)90295-2
---------- CHICAGO ----------
Paredes, S.R., de Geralnik, A.A.J., Del C. Batlle, A.M., Conti, H.A. "Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy" . International Journal of Biochemistry 17, no. 5 (1985) : 625-629.
http://dx.doi.org/10.1016/0020-711X(85)90295-2
---------- MLA ----------
Paredes, S.R., de Geralnik, A.A.J., Del C. Batlle, A.M., Conti, H.A. "Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy" . International Journal of Biochemistry, vol. 17, no. 5, 1985, pp. 625-629.
http://dx.doi.org/10.1016/0020-711X(85)90295-2
---------- VANCOUVER ----------
Paredes, S.R., de Geralnik, A.A.J., Del C. Batlle, A.M., Conti, H.A. Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy. Int. J. Biochem. 1985;17(5):625-629.
http://dx.doi.org/10.1016/0020-711X(85)90295-2