Navegar

Colección

Datos Estadísticas

Artículo

Este artículo esta disponible en la web de forma gratuita y puede ser descargado en su versión final
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983.

Registro:

Documento: Artículo
Título:Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
Autor:Del C. Batlle, A.M.; Bustos, N.L.; Stella, A.M.; Wider, E.A.; Conti, H.A.; Mendez, A.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET y FCE y N. University of B. Aires), Ciudad Universitaria, Pabellon II, 1428 Buenos Aires, Argentine, Argentina
Unidad B-4 de Clinica Medica, Hospital Ramos Mejia, Gral. Urquiza 609, 1221 Buenos Aires, Argentine
Palabras clave:lead; porphobilinogen synthase; blood and hemopoietic system; case report; drug therapy; drug toxicity; enzyme therapy; erythrocyte ghost; human; intoxication; lead poisoning; porphyria; therapy; Adult; Coproporphyrins; Erythrocyte Membrane; Humans; Injections, Intravenous; Lead Poisoning; Male; Porphobilinogen Synthase; Porphyrins; Uroporphyrins
Año:1983
Volumen:15
Número:10
Página de inicio:1261
Página de fin:1265
DOI: http://dx.doi.org/10.1016/0020-711X(83)90216-1
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:lead, 13966-28-4, 7439-92-1; porphobilinogen synthase, 9036-37-7; Coproporphyrins; Porphobilinogen Synthase, 4.2.1.24; Porphyrins; Uroporphyrins
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_0020711X_v15_n10_p1261_DelCBatlle.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v15_n10_p1261_DelCBatlle

Referencias:

  • Batlle, Ferramola, Grinstein, Purification and general properties of delta aminolaevulic acid dehydratase from cow liver (1967) Biochem. J., 104, pp. 244-249
  • Beutler, Enzyme replacement therapy (1981) Trends biochem. Sci., 6, pp. 95-97
  • Beutler, Dale, Guinto, Kuhl, Enzyme replacement therapy in Gaucher's disease: Preliminary clinical trial of a new enzyme preparation (1977) Proc. natn. Acad. Sci. U.S.A., 74, pp. 4620-4623
  • Bjorksten, The crosslinking theory of aging (1968) J Am Geriatr Soc, 16, pp. 408-427
  • Bustos, Stella, Wider, Batlle, Studies on erythrocyte aminolaevulinate dehydratase I. Its purification and possible therapeutic applications (1980) Int. J. Biochem., 12, pp. 745-749
  • Bustos, Stella, Wider, Batlle, Enzyme replacement therapy in Porphyrias—III. Potential use of erythrocyte ghosts as carriers of α-aminolaevulinate dehydratase (1983) Int. J. Biochem., 15, pp. 447-452
  • Bustos, Stella, Wider, Batlle, (1983) Enzyme replacement therapy in Porphyrias V: In vivo correction of δ -aminolaevulinate dehydratase defective erythrocytes in lead intoxicated animals by enzyme-loaded erythrocyte ghosts, , n preparation
  • Egorova, Ivanov, Sanotskij, Specificity of the effect of lead on spermatogenesis (1966) Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv, 3, pp. 33-41. , A.A. Letavet, I.Y. Sanotskij, Meditsena, Moscow
  • Espinola, Wider, Stella, Batlli, Enzyme replacement therapy in Porphyrias—II. Entrapment of δ -aminolaevulinate dehydratase in liposomes (1983) Int. J. Biochem., 15, pp. 439-445
  • Ihler, Potential use of erythrocytes as carriers for enzymes and drugs (1979) Drug Carriers in Biology and Medicine, pp. 129-153. , G. Gregoriadis, Academic Press, New York
  • Kesten, Stella, Wider, Batlli, Effect of cadmium on porphyrin biosynthesis 1 (1980) Int. J. Biochem., 12, pp. 905-908
  • Lancranjean, Popescu, Gavanescu, Klepsch, Serbanescu, Reproduction ability of workmen occupationallv exposed to lead (1975) Archives of Environmental Health: An International Journal, 30, pp. 396-401
  • Mauzerall, Granick, The occurrence and determination of α-aminolaevulinic acid and porphobilinogen in urine (1976) J. biol. Chem., 219, pp. 435-446
  • Neshkou, The influence of chronic intoxications with leaded-gasoline on spermatogenesis and sexual functions in man (1971) Gig. Truda prof. Zabol., 15, pp. 45-49
  • Rimington, Quantitative determination of porphobilinogen and porphyrins in faeces and erythrocytes (1971) Ass. clin. Path-Broadsheet 70, , (Revised Broadsheet 36)
  • Ryman, Enzymes in therapy (1977) Inaug. Sci. Meet. Int. Soc. clin. Enzym., pp. 222-227. , London, Enzymes in Health and Disease, Karger, Basel, 1978

Citas:

---------- APA ----------
Del C. Batlle, A.M., Bustos, N.L., Stella, A.M., Wider, E.A., Conti, H.A. & Mendez, A. (1983) . Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts. International Journal of Biochemistry, 15(10), 1261-1265.
http://dx.doi.org/10.1016/0020-711X(83)90216-1
---------- CHICAGO ----------
Del C. Batlle, A.M., Bustos, N.L., Stella, A.M., Wider, E.A., Conti, H.A., Mendez, A. "Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts" . International Journal of Biochemistry 15, no. 10 (1983) : 1261-1265.
http://dx.doi.org/10.1016/0020-711X(83)90216-1
---------- MLA ----------
Del C. Batlle, A.M., Bustos, N.L., Stella, A.M., Wider, E.A., Conti, H.A., Mendez, A. "Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts" . International Journal of Biochemistry, vol. 15, no. 10, 1983, pp. 1261-1265.
http://dx.doi.org/10.1016/0020-711X(83)90216-1
---------- VANCOUVER ----------
Del C. Batlle, A.M., Bustos, N.L., Stella, A.M., Wider, E.A., Conti, H.A., Mendez, A. Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts. Int. J. Biochem. 1983;15(10):1261-1265.
http://dx.doi.org/10.1016/0020-711X(83)90216-1