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Eva Kesten, M.; Stella, A.M.; Eva Wider De Xifra, A.; Alcira Del Batlle, M.C. "Effect of cadmium on porphyrin biosynthesis-I" (1980) International Journal of Biochemistry. 12(5-6):905-908
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Abstract:

1. 1. Female Sprague-Dawley rats were exposed to Cd (50 ppm) administered in drinking water. 2. 2. The oral uptake of Cd did not alter δ-aminolevulinate and porphobilinogen urinary excretion nor the total content of daily porphyrin excretion in either urine or feces. 3. 3. A significant and consistent difference in the composition of porphyrin in feces between control and Cd-exposed rats was observed. In the latter group a constant increase of coproporphyrin and a concomitant decrease in protoporphyrin was found. 4. 4. After 94 days exposure, Cd levels in blood and urine were low, and very high in kidney and liver. In red cells the activity of ALA-D was 40% reduced, and only a 20% decrease was observed for PBGase and deaminase. In kidney and liver ALA-D, PBGase and deaminase activities were the same in both control and Cd-intoxicated rats. 5. 5. It is suggested that determination of the ratio protoporphyrin:coproporphyrin in feces and ALA-D activity in red cells might be a biological index of Cd intoxication. © 1980.

Registro:

Documento: Artículo
Título:Effect of cadmium on porphyrin biosynthesis-I
Autor:Eva Kesten, M.; Stella, A.M.; Eva Wider De Xifra, A.; Alcira Del Batlle, M.C.
Filiación:Centro de Investigaciones sobre Porfirinas (CIPYP), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, 4to Piso, Nuñez, 1428 Buenos Aires, Argentina
Cátedra de Toxicologia del Departamento de Quimica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, 4to Piso, Núñez, 1428 Buenos Aires, Argentina
Palabras clave:cadmium; porphyrin; animal experiment; blood; blood and hemopoietic system; heavy metal poisoning; kidney; liver; oral drug administration; preliminary communication; rat; Aminolevulinic Acid; Ammonia-Lyases; Animal; Cadmium; Cadmium Poisoning; Erythrocytes; Feces; Female; Kidney; Kinetics; Liver; Porphobilinogen; Porphobilinogen Synthase; Porphyrins; Rats; Support, Non-U.S. Gov't
Año:1980
Volumen:12
Número:5-6
Página de inicio:905
Página de fin:908
DOI: http://dx.doi.org/10.1016/0020-711X(80)90183-4
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:cadmium, 22537-48-0, 7440-43-9; porphyrin, 24869-67-8; Aminolevulinic Acid, 106-60-5; Ammonia-Lyases, EC 4.3.1.; Cadmium, 7440-43-9; Porphobilinogen Synthase, EC 4.2.1.24; Porphobilinogen, 487-90-1; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v12_n5-6_p905_EvaKesten

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Citas:

---------- APA ----------
Eva Kesten, M., Stella, A.M., Eva Wider De Xifra, A. & Alcira Del Batlle, M.C. (1980) . Effect of cadmium on porphyrin biosynthesis-I. International Journal of Biochemistry, 12(5-6), 905-908.
http://dx.doi.org/10.1016/0020-711X(80)90183-4
---------- CHICAGO ----------
Eva Kesten, M., Stella, A.M., Eva Wider De Xifra, A., Alcira Del Batlle, M.C. "Effect of cadmium on porphyrin biosynthesis-I" . International Journal of Biochemistry 12, no. 5-6 (1980) : 905-908.
http://dx.doi.org/10.1016/0020-711X(80)90183-4
---------- MLA ----------
Eva Kesten, M., Stella, A.M., Eva Wider De Xifra, A., Alcira Del Batlle, M.C. "Effect of cadmium on porphyrin biosynthesis-I" . International Journal of Biochemistry, vol. 12, no. 5-6, 1980, pp. 905-908.
http://dx.doi.org/10.1016/0020-711X(80)90183-4
---------- VANCOUVER ----------
Eva Kesten, M., Stella, A.M., Eva Wider De Xifra, A., Alcira Del Batlle, M.C. Effect of cadmium on porphyrin biosynthesis-I. Int. J. Biochem. 1980;12(5-6):905-908.
http://dx.doi.org/10.1016/0020-711X(80)90183-4