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Abstract:

1. 1. Studies were carried out in order to clarify if pentachlorophenol (PCP), one of the hexachlorobenzene (HCB) metabolites, produces disturbances similar to that of HCB in the porphyrin metabolism. PCP could be the drug through which the porphyrinogenic action of HCB is mediated. 2. 2. The action of technical and purified PCP on (a) the urinary excretion of ALA, PBG and porphyrins, (b) porphyrin accumulation in several tissues, (c) the activity of hepatic ALA-synthetase and Uro'gen decarboxylase has been studied in rats. The effect of purified drug on the porphyrin content and activity of the first enzyme was also investigated in chick embryos. 3. 3. The results obtained with technical PCP indicate that it produces: (a) marked increases in the excretion levels: porphyrins ≫ PBG ≫ ALA, the excretion peaks being at approx 15-16 weeks of treatment; (b) porphyrin accumulation in spleen, kidney and liver, in this order and being very marked in the latter at 970 μg/g; (c) increased ALA-synthetase (2.5 times) and a remarkable decrease (98%) in the porphyrinogen carboxy-lyase. 4. 4. Purified PCP does not significantly modify the parameters studied in rats. However, it does raise the levels of porphyrins and the activity of ALA-synthetase in the liver of 17-day-old chick embryo. 5. 5. The results obtained would indicate that in rats, only technical PCP is able to produce a definite and similar porphyria to that of HCB, while the purified drug does not. So, PCP alone does not seem to play an important role in the production mechanism of HCB porphyria. © 1980.

Registro:

Documento: Artículo
Título:Effect of chlorophenols on porphyrin metabolism in rats and chick embryo
Autor:De Calmanovici, R.W.; De Viale, L.C.S.M.
Filiación:Laboratorio de Porfirinas, Departmento de Quimica Biológica, Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, Ciudad Universitaria, Núñez, 1428 Buenos Aires, Argentina
Palabras clave:enzyme; pentachlorophenol; porphyrin; animal experiment; chicken; drug intoxication; drug urine level; embryo; intoxication; kidney; liver; oral drug administration; porphyria; preliminary communication; rat; spleen; 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animal; Chick Embryo; Chlorophenols; Female; Intestines; Kidney; Liver; Pentachlorophenol; Porphobilinogen; Porphyrins; Rats; Species Specificity; Spleen; Support, Non-U.S. Gov't
Año:1980
Volumen:12
Número:5-6
Página de inicio:1039
Página de fin:1044
DOI: http://dx.doi.org/10.1016/0020-711X(80)90208-6
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:pentachlorophenol, 87-86-5; porphyrin, 24869-67-8; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Aminolevulinic Acid, 106-60-5; Chlorophenols; Pentachlorophenol, 87-86-5; Porphobilinogen, 487-90-1; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v12_n5-6_p1039_DeCalmanovici

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Citas:

---------- APA ----------
De Calmanovici, R.W. & De Viale, L.C.S.M. (1980) . Effect of chlorophenols on porphyrin metabolism in rats and chick embryo. International Journal of Biochemistry, 12(5-6), 1039-1044.
http://dx.doi.org/10.1016/0020-711X(80)90208-6
---------- CHICAGO ----------
De Calmanovici, R.W., De Viale, L.C.S.M. "Effect of chlorophenols on porphyrin metabolism in rats and chick embryo" . International Journal of Biochemistry 12, no. 5-6 (1980) : 1039-1044.
http://dx.doi.org/10.1016/0020-711X(80)90208-6
---------- MLA ----------
De Calmanovici, R.W., De Viale, L.C.S.M. "Effect of chlorophenols on porphyrin metabolism in rats and chick embryo" . International Journal of Biochemistry, vol. 12, no. 5-6, 1980, pp. 1039-1044.
http://dx.doi.org/10.1016/0020-711X(80)90208-6
---------- VANCOUVER ----------
De Calmanovici, R.W., De Viale, L.C.S.M. Effect of chlorophenols on porphyrin metabolism in rats and chick embryo. Int. J. Biochem. 1980;12(5-6):1039-1044.
http://dx.doi.org/10.1016/0020-711X(80)90208-6