Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

1. 1. Heptachlor and lindane are widespread chlorinated insecticides. But porphyrinogen carboxy-lyase seems to be a key enzyme in the porphyria produced by chlorinated compounds in mammals. It was then considered interesting to perform the present investigation, the purpose of which was to study: (a) the porphyrinogenic ability of heptachlor and lindane when they were administered in vivo to whole chick embryo and (b) the in vivo effect of heptachlor and lindane on porphyrinogen carboxy-lyase activity. 2. 2. The results obtained showed that both compounds produce a significant accumulation of hepatic porphyrins, that produced by lindane being greater than that produced by heptachlor. 3. 3. The effect of heptachlor and lindane administration on porphyrinogen carboxy-lyase was studied in embryos from New Hampshire and Leghorn strains and in New Hampshire 1-day old chicks. The influence of phenobarbital and SKF-525 A pretreatment on the response of porphyrinogen carboxy-lyase to these drugs was also studied in New Hampshire chick embryos. The results indicate that the drugs do not produce decreased enzyme activity in the New Hampshire embryos, while a decrease of enzyme activity in the White Leghorn embryos and in the New Hampshire new-born chicks was observed. Results from pretreatment assays suggest that the decrease of porphyrinogen carboxy-lyase activity seems to be associated with the formation of a drug metabolite. 4. 4. It is concluded that heptachlor and lindane are porphyrinogenic drugs and that the response of decarboxylating enzyme to them seems to be dependent on: (a) the strain, (b) the development of the animal and (c) the drug metabolization system; some of the lindane and heptachlor metabolites being responsible for hepatic porphyrinogen carboxy-lyase decrease. © 1980.

Registro:

Documento: Artículo
Título:Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane
Autor:Taira, M.C.; De Viale, L.C.S.M.
Filiación:Laboratorio de porfirinas, Departamento de Quimica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Núñez, 1428 Buenos Aires, Argentina
Palabras clave:heptachlor; lindane; porphyrin; Carboxy Lyases; carboxylyase; heptachlor; lindane; porphyrin; porphyrinogen; porphyrinogen carboxy lyase; porphyrinogen carboxy-lyase; proadifen; animal experiment; chicken; embryo; etiology; hepatic porphyria; human cell; liver; pollution; porphyrinogen carboxylase; preliminary communication; animal; article; chick embryo; drug effect; enzymology; metabolism; Animal; Carboxy-Lyases; Chick Embryo; Heptachlor; Lindane; Liver; Porphyrinogens; Porphyrins; Proadifen; Support, Non-U.S. Gov't
Año:1980
Volumen:12
Número:5-6
Página de inicio:1033
Página de fin:1038
DOI: http://dx.doi.org/10.1016/0020-711X(80)90207-4
Título revista:International Journal of Biochemistry
Título revista abreviado:Int. J. Biochem.
ISSN:0020711X
CODEN:IJBOB
CAS:heptachlor, 33442-83-0, 76-44-8; lindane, 58-89-9; porphyrin, 24869-67-8; carboxylyase, 9027-22-9; porphyrinogen, 4396-11-6; proadifen, 302-33-0, 62-68-0; Carboxy-Lyases, EC 4.1.1.; Heptachlor, 76-44-8; Lindane, 58-89-9; porphyrinogen carboxy-lyase, EC 4.1.1.-; Porphyrinogens; Porphyrins; Proadifen, 302-33-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v12_n5-6_p1033_Taira

Referencias:

  • Creighton, Marks, Drug-induced porphyrin biosynthesis. I. The effect of porphyria-inducing drug on N-demethylase activity of chick embryo liver (1969) Biochem. Pharmac., 18, pp. 2040-2045
  • De Matteis, Drugs and porphyria (1971) S. Afr. Med. J., 45, pp. 126-133
  • Granick, The induction in vitro of the synthesis of δ-aminolevulinic acid synthetase in chemical porphyria: A response to certain drugs, sex hormones and foreign chemicals (1966) J. biol. Chem., 241, pp. 1359-1375
  • Granick, Kappas, Steroid induction of porphyrin synthesis in liver cells culture. I. Structural basis and possible physiological role in the control of heme formation (1967) J. biol. Chem., 242, pp. 4587-4593
  • Jones, Sweeney, Association between induction of aryl hydrocarbon hydroxylase and depression of uroporphyrinogen decarboxylase activity (1977) Res. Commun. Chem. Path. Pharmac., 17, pp. 631-637
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Mauzerall, Granick, Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase (1958) J. biol. Chem., 232, pp. 1141-1162
  • Racz, Marks, Drug-induced porphyrin biosynthesis. II. Simple procedure for screening drugs for porphyria inducing activity (1969) Biochem. Pharmac., 18, pp. 2009-2018
  • Rifkind, Gillette, Song, Kappas, Drug stimulation of δ-aminolevulinic acid synthetase and cytochrome P-450 in vivo in chick embryo liver (1973) J. Pharmac. exp. Ther., 185, pp. 214-225
  • San Martin De Viale, Rios De Molina, Wainstok De Calmanovici, Tomio, Porphyrins and porphyrinogen carboxy-lase in hexachlorobenzene-induced porphyria (1977) Biochem. J., 168, pp. 393-400
  • San Martin De Viale, Viale, Nacht, Grinstein, Experimental porphyria induced in rats by hexachlorobenzene Study of the porphyrins excreted by urine (1970) Clinica Chimica Acta, 28, pp. 13-23
  • Simon, Siklosi, Experimentelles porphyria-modell mit hexachlorcyklohexan (1974) Z. Hautkr., 49, pp. 497-504
  • Simon, Siklosi, Effect of antimycotics on the porphyrin metabolism (1976) Mykosen, 19, pp. 98-104
  • Sinclair, Granick, Uroporphyrinogen formation induced by chlorinated hydrocarbons (lindane, polychlorinated biphyenyls, tetrachlorodibenzo-p-dioxin). Requirements for endogenous iron, protein synthesis and drug metabolizing activity (1974) Biochem. biophys. Res. Commun., 61, pp. 124-133
  • Snelson, The importance of chlorinated hydrocarbons in world agriculture (1977) Ecotoxicol. Envir. Safety, 1, pp. 17-32
  • Tomio, Garcia, San Martin De Viale, Grinstein, Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes—Purification and properties (1970) Biochim. biophys. Acta, 198, pp. 353-363
  • Wainstok De, San Martin De Viale, Effect of chlorophenols on porphyrin metabolism in rats and chick embryo (1980) Int. J. Biochem., 12, pp. 1039-1044

Citas:

---------- APA ----------
Taira, M.C. & De Viale, L.C.S.M. (1980) . Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane. International Journal of Biochemistry, 12(5-6), 1033-1038.
http://dx.doi.org/10.1016/0020-711X(80)90207-4
---------- CHICAGO ----------
Taira, M.C., De Viale, L.C.S.M. "Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane" . International Journal of Biochemistry 12, no. 5-6 (1980) : 1033-1038.
http://dx.doi.org/10.1016/0020-711X(80)90207-4
---------- MLA ----------
Taira, M.C., De Viale, L.C.S.M. "Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane" . International Journal of Biochemistry, vol. 12, no. 5-6, 1980, pp. 1033-1038.
http://dx.doi.org/10.1016/0020-711X(80)90207-4
---------- VANCOUVER ----------
Taira, M.C., De Viale, L.C.S.M. Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane. Int. J. Biochem. 1980;12(5-6):1033-1038.
http://dx.doi.org/10.1016/0020-711X(80)90207-4