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Abstract:

Carbon monoxide releasing molecules (CORMs) have important bactericidal, anti-inflammatory, neuroprotective, and antiapoptotic effects and can be used as tools for CO physiology experiments, including studies on vasodilation. In this context, a new class of CO releasing molecules, based on pentachlorocarbonyliridate(III) derivative have been recently reported. Although there is a growing interest in the characterization of protein-CORMs interactions, only limited structural information on CORM binding to protein and CO release has been available to date. Here, we report six different crystal structures describing events ranging from CORM entrance into the protein crystal up to the CO release and a biophysical characterization by isothermal titration calorimetry, Raman microspectroscopy, and molecular dynamics simulations of the complex between a pentachlorocarbonyliridate(III) derivative and hen egg white lysozyme, a model protein. Altogether, the data indicate the formation of a complex in which the ligand can bind to different sites of the protein surface and provide clues on the mechanism of adduct formation and CO release. © 2014 American Chemical Society.

Registro:

Documento: Artículo
Título:Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release
Autor:Petruk, A.A.; Vergara, A.; Marasco, D.; Bikiel, D.; Doctorovich, F.; Estrin, D.A.; Merlino, A.
Filiación:Departamento de Química Inorgánica, Analítica y Química Física, University of Buenos Aires, Ciudad Universitaria, Pab. 2, Buenos Aires, C1428EHA, Argentina
Department of Chemical Sciences, University of Naples Federico II, via Cintia, Napoli, I-80126, Italy
CNR Institute of Biostructures and Bioimages, Via Mezzocannone 16, Napoli, I-80100, Italy
Department of Pharmacy, CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples Federico II, Via Mezzocannone, 16, Napoli, 80134, Italy
Palabras clave:carbon monoxide; hen egg lysozyme; iridium; lysozyme; organometallic compound; chemistry; metabolism; molecular dynamics; synthesis; Carbon Monoxide; Iridium; Molecular Dynamics Simulation; Muramidase; Organometallic Compounds
Año:2014
Volumen:53
Número:19
Página de inicio:10456
Página de fin:10462
DOI: http://dx.doi.org/10.1021/ic501498g
Título revista:Inorganic Chemistry
Título revista abreviado:Inorg. Chem.
ISSN:00201669
CODEN:INOCA
CAS:carbon monoxide, 630-08-0; iridium, 13967-67-4, 7439-88-5; lysozyme, 9001-63-2; Carbon Monoxide; hen egg lysozyme; Iridium; Muramidase; Organometallic Compounds
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00201669_v53_n19_p10456_Petruk

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Citas:

---------- APA ----------
Petruk, A.A., Vergara, A., Marasco, D., Bikiel, D., Doctorovich, F., Estrin, D.A. & Merlino, A. (2014) . Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release. Inorganic Chemistry, 53(19), 10456-10462.
http://dx.doi.org/10.1021/ic501498g
---------- CHICAGO ----------
Petruk, A.A., Vergara, A., Marasco, D., Bikiel, D., Doctorovich, F., Estrin, D.A., et al. "Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release" . Inorganic Chemistry 53, no. 19 (2014) : 10456-10462.
http://dx.doi.org/10.1021/ic501498g
---------- MLA ----------
Petruk, A.A., Vergara, A., Marasco, D., Bikiel, D., Doctorovich, F., Estrin, D.A., et al. "Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release" . Inorganic Chemistry, vol. 53, no. 19, 2014, pp. 10456-10462.
http://dx.doi.org/10.1021/ic501498g
---------- VANCOUVER ----------
Petruk, A.A., Vergara, A., Marasco, D., Bikiel, D., Doctorovich, F., Estrin, D.A., et al. Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release. Inorg. Chem. 2014;53(19):10456-10462.
http://dx.doi.org/10.1021/ic501498g