Abstract:
Carbon monoxide releasing molecules (CORMs) have important bactericidal, anti-inflammatory, neuroprotective, and antiapoptotic effects and can be used as tools for CO physiology experiments, including studies on vasodilation. In this context, a new class of CO releasing molecules, based on pentachlorocarbonyliridate(III) derivative have been recently reported. Although there is a growing interest in the characterization of protein-CORMs interactions, only limited structural information on CORM binding to protein and CO release has been available to date. Here, we report six different crystal structures describing events ranging from CORM entrance into the protein crystal up to the CO release and a biophysical characterization by isothermal titration calorimetry, Raman microspectroscopy, and molecular dynamics simulations of the complex between a pentachlorocarbonyliridate(III) derivative and hen egg white lysozyme, a model protein. Altogether, the data indicate the formation of a complex in which the ligand can bind to different sites of the protein surface and provide clues on the mechanism of adduct formation and CO release. © 2014 American Chemical Society.
Registro:
Documento: |
Artículo
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Título: | Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release |
Autor: | Petruk, A.A.; Vergara, A.; Marasco, D.; Bikiel, D.; Doctorovich, F.; Estrin, D.A.; Merlino, A. |
Filiación: | Departamento de Química Inorgánica, Analítica y Química Física, University of Buenos Aires, Ciudad Universitaria, Pab. 2, Buenos Aires, C1428EHA, Argentina Department of Chemical Sciences, University of Naples Federico II, via Cintia, Napoli, I-80126, Italy CNR Institute of Biostructures and Bioimages, Via Mezzocannone 16, Napoli, I-80100, Italy Department of Pharmacy, CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples Federico II, Via Mezzocannone, 16, Napoli, 80134, Italy
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Palabras clave: | carbon monoxide; hen egg lysozyme; iridium; lysozyme; organometallic compound; chemistry; metabolism; molecular dynamics; synthesis; Carbon Monoxide; Iridium; Molecular Dynamics Simulation; Muramidase; Organometallic Compounds |
Año: | 2014
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Volumen: | 53
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Número: | 19
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Página de inicio: | 10456
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Página de fin: | 10462
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DOI: |
http://dx.doi.org/10.1021/ic501498g |
Título revista: | Inorganic Chemistry
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Título revista abreviado: | Inorg. Chem.
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ISSN: | 00201669
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CODEN: | INOCA
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CAS: | carbon monoxide, 630-08-0; iridium, 13967-67-4, 7439-88-5; lysozyme, 9001-63-2; Carbon Monoxide; hen egg lysozyme; Iridium; Muramidase; Organometallic Compounds
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00201669_v53_n19_p10456_Petruk |
Referencias:
- Motterlini, R., Sawle, P., Hammad, J., Bains, S., Alberto, R., Foresti, R., Green, C.J., (2005) FASEB J., 19, pp. 284-286
- Johnson, T.R., Mann, B.E., Clark, J.E., Foresti, R., Green, C.J., Motterlini, R., (2003) Angew. Chem., Int. Ed., 42, pp. 3722-3729
- Motterlini, R., Clark, J.E., Foresti, R., Sarathchandra, P., Mann, B.E., Green, C.J., (2002) Circ. Res., 90, pp. 17-24
- Pizarro, M.D., Rodriguez, J.V., Mamprin, M.E., Fuller, B.J., Mann, B.E., Motterlini, R., Guibert, E.E., (2009) Cryo-biology, 58, pp. 248-255
- Desmard, M., Davidge, K.S., Bouvet, O., Morin, D., Roux, D., Foresti, R., Ricard, J.D., Boczkowski, J., (2009) FASEB J., 23, pp. 1023-1031
- Bani-Hani, M.G., Greenstein, D., Mann, B.E., Green, C.J., Motterlini, R., (2006) Pharmacol. Rep., 58, pp. 132-144
- Motterlini, R., Haas, B., Foresti, R., (2012) Med. Gas Res., 2, p. 28
- Schallner, N., Schwemmers, S., Schwer, C.I., Froehlich, C., Stoll, P., Humar, M., Pahl, H.L., Goebel, U., (2011) Eur. J. Pharmacol., 670, pp. 58-66
- Wilson, J.L., Jesse, H.E., Hughes, B.M., Lund, V., Naylor, K., Davidge, K.S., Cook, G.M., Poole, R.K., (2013) Antioxid. Redox Signal, 19, pp. 497-509
- Schwer, C.I., Mutschler, M., Stoll, P., Goebel, U., Humar, M., Hoetzel, A., Schmidt, R., (2010) Mol. Pharmacol., 77, pp. 660-669
- Mahan, V.L., (2012) Med. Gas Res., 2, p. 32
- Atkin, J., Williams, S., Sawle, P., Motterlini, R., Lynam, J.M., Fairlamb, I.J., (2009) Dalton Trans., 19, pp. 3653-3656
- Rudolf, P., Kanal, F., Gehrig, D., Niesel, J., Brixner, T., Schatzschneider, U., Nuernberger, P., (2013) J. Phys. Chem. Lett., 4, pp. 596-602
- Bikiel, D.E., Gonzalez Solveyra, E., Di Salvo, F., Milagre, H.M., Eberlin, M.N., Correa, R.S., Ellena, J., Doctorovic, F., (2011) Inorg. Chem., 50, pp. 2334-2345
- Boczkowski, J., Poderoso, J.J., Motterlini, R., (2006) Trends Biochem. Sci., 31, pp. 614-621
- Herrick, R.S., Ziegler, C.J., Leeper, T.C., (2014) J. Organomet. Chem., 751, pp. 90-110
- Santos-Silva, T., Mukhopadhyay, A., Seixas, J.D., Bernardes, G.J., Romao, C.C., Romao, M.J., (2011) J. Am. Chem. Soc., 133, pp. 1192-1195
- Santos-Silva, T., Mukhopadhyay, A., Seixas, J.D., Bernardes, G.J., Romao, C.C., Romao, M.J., (2011) Curr. Med. Chem., 18, pp. 3361-3366
- Santos, M.F.A., Seixas, J.D., Coelho, A., Mukhopadhyay, A., Reis, P.M., Romao, M.J., Romao, C.C., Santos-Silva, T., (2012) J. Inorg. Biochem., 117, pp. 285-291
- Seixas, J.D., Mukhopadhyay, A., Santos-Silva, T., Otterbein, L.E., Gallo, D.J., Rodrigues, S.S., Guerreiro, B.H., Romao, C.C., (2013) Dalton. Trans., 42, pp. 5985-5998
- Russo Krauss, I., Sica, F., Mattia, C.A., Merlino, A., (2012) Int. J. Mol. Sci., 13, pp. 3782-3800
- Minor, W., Cymborowski, M., Otwinowski, Z., Chruszcz, M., (2006) Acta Cryst. D, 62, pp. 859-866
- Brunger, T., Adams, P.D., Clore, G.M., Delano, W.L., Gros, P., Grosse-Kunstleve, R.W., Jiang, J.S., Warren, G.L., (1998) Acta Cryst. D, 54, pp. 905-921
- Vaney, M.C., Maignan, S., Ries-Kautt, M., Ducriux, A., (1996) Acta Cryst. D, 52, pp. 505-517
- Jones, T.A., Zou, J.Y., Cowan, S.W., Kjeldgaar, M., (1991) Acta Cryst. A, 47, pp. 110-119
- Laskowski, R.A., MacArthur, M.W., Moss, D.S., Thornton, J.M., (1993) J. Appl. Crystallogr., 26, pp. 283-291
- Hooft, R.W., Sander, C., Vriend, G., (1997) Comput. Appl. Biosci., 13, pp. 425-430
- Vergara, A., Merlino, A., Pizzo, E., D'Alessio, G., Mazzarella, L., (2008) Acta Cryst. D, 64, pp. 167-171
- Jorgensen, W.L., Chandrasekhar, J., Madura, J.D., Impey, R.W., Klein, M.L., (1983) J. Chem. Phys., 79, p. 926
- Luty, B.A., Tironi, I.G., (1995) Chem. Phys., 103, p. 3014
- Case, D.A., Darden, T.A., Cheatham, T.E., Simmerling, C.L., Wang, J., Duke, R.E., Luo, R., Kollman, P.A., (2008) Amber 10, , University of California: San Francisco
- Wang, J., Wolf, R.M., Caldwell, J.W., Kollman, P.A., Case, D.A., (2004) J. Comput. Chem., 25, pp. 1157-1174
- Rulisek, L., Ryde, U., (2006) J. Phys. Chem. B, 110, pp. 11511-11518
- Bayly, C.I., Cieplak, P., Cornell, W., Kollman, P.A., (1993) J. Phys. Chem. B, 97, pp. 10269-10280
- Cohen, J., Arkhipov, A., Braun, R., Schulten, K., (2006) Biophys. J., 91, pp. 1844-1857
- Forti, F., Boechi, L., Estrin, D.A., Marti, M.A., (2011) J. Comput. Chem., 32, pp. 2219-2231
- Boechi, L., Marti, M.A., Vergara, A., Sica, F., Mazzarella, L., Estrin, D.A., Merlino, A., (2011) IUBMB Life, 63, pp. 175-182
- Policar, C., Waern, J.B., Plamont, M.-A., Clede, S., Mayer, C., Prazeres, R., Ortega, J.-M., Dazzi, A., (2011) Angew. Chem., Int. Ed., 123, pp. 890-894
- Clede, S., Lambert, F., Sandt, C., Gueroui, Z., Refregiers, M., Plamont, M.-A., Dumas, P., Policar, C., (2012) Chem. Commun., 48, pp. 7729-7731
- Kong, K.V., Lam, Z., Lau, W.K.O., Leong, W.K., Olivo, M., (2013) J. Am. Chem. Soc., 135, pp. 18028-18031
- Meister, K., Niesel, J., Schatzschneider, U., Metzler-Nolte, N., Schmidt, D.A., Havenith, M., (2010) Angew. Chem., Int. Ed., 49, pp. 3310-3312
- Metrangolo, P., Resnati, G., (2001) Chemistry, 7, pp. 2511-2519
- Metrangolo, P., Neukirch, H., Pilati, T., Resnati, G., (2005) Acc. Chem. Res., 38, pp. 386-395
- Cavallo, G., Metrangolo, P., Pilati, T., Resnati, G., Sansotera, M., Terraneo, G., (2011) Chem. Soc. Rev., 39, pp. 3772-3783
Citas:
---------- APA ----------
Petruk, A.A., Vergara, A., Marasco, D., Bikiel, D., Doctorovich, F., Estrin, D.A. & Merlino, A.
(2014)
. Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release. Inorganic Chemistry, 53(19), 10456-10462.
http://dx.doi.org/10.1021/ic501498g---------- CHICAGO ----------
Petruk, A.A., Vergara, A., Marasco, D., Bikiel, D., Doctorovich, F., Estrin, D.A., et al.
"Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release"
. Inorganic Chemistry 53, no. 19
(2014) : 10456-10462.
http://dx.doi.org/10.1021/ic501498g---------- MLA ----------
Petruk, A.A., Vergara, A., Marasco, D., Bikiel, D., Doctorovich, F., Estrin, D.A., et al.
"Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release"
. Inorganic Chemistry, vol. 53, no. 19, 2014, pp. 10456-10462.
http://dx.doi.org/10.1021/ic501498g---------- VANCOUVER ----------
Petruk, A.A., Vergara, A., Marasco, D., Bikiel, D., Doctorovich, F., Estrin, D.A., et al. Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release. Inorg. Chem. 2014;53(19):10456-10462.
http://dx.doi.org/10.1021/ic501498g