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Abstract:

In this study we evaluated the relationship between nitric oxide (NO) and macrophage antiviral extrinsic activity. Macrophages activated by intraperitoneal injection of herpes simplex virus-2 (HSV-2), showed both extrinsic antiviral activity and high nitrite production in contrast to non-activated, resident macrophages. The extrinsic antiviral activity was observed in cultures of Vero cells infected with HSV-1 and HSV-2. The NO inhibitor N-monomethyl-L-arginine acetate (L-NMA) impaired the antiviral activity of HSV-elicited macrophages. The effect was dose dependent and correlated with a reduction of nitrite in the culture media. The effect of L-NMA was reversed by the addition of L-arginine. These data indicate that NO could be responsible for the described activity. Furthermore, L-NMA treatment resulted in the aggravation of HSV1-induced keratitis in the mouse model, supporting a defensive role of NO in the pathogenesis of HSV-1 corneal infection.

Registro:

Documento: Artículo
Título:Nitric oxide and macrophage antiviral extrinsic activity
Autor:Benencia, F.; Courreges, M.C.
Filiación:Laboratorio de Inmunoquímica, Depto. Quimica Biológica, Universidad de Buenos Aires, Pabellón 11, (1428) Buenos Aires, Argentina
Palabras clave:n(g) methylarginine; nitric oxide; animal cell; animal experiment; animal model; article; controlled study; female; herpes simplex keratitis; herpes simplex virus 1; herpes simplex virus 2; host resistance; immunoreactivity; infection resistance; macrophage activation; mouse; nonhuman; priority journal; signal transduction; Animals; Cercopithecus aethiops; Dose-Response Relationship, Drug; Female; Herpesvirus 1, Human; Herpesvirus 2, Human; Keratitis, Herpetic; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitrites; omega-N-Methylarginine; Vero Cells; Virus Replication
Año:1999
Volumen:98
Número:3
Página de inicio:363
Página de fin:370
DOI: http://dx.doi.org/10.1046/j.1365-2567.1999.00864.x
Título revista:Immunology
Título revista abreviado:Immunology
ISSN:00192805
CODEN:IMMUA
CAS:Nitric Oxide, 10102-43-9; Nitrites; omega-N-Methylarginine, 17035-90-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00192805_v98_n3_p363_Benencia

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Citas:

---------- APA ----------
Benencia, F. & Courreges, M.C. (1999) . Nitric oxide and macrophage antiviral extrinsic activity. Immunology, 98(3), 363-370.
http://dx.doi.org/10.1046/j.1365-2567.1999.00864.x
---------- CHICAGO ----------
Benencia, F., Courreges, M.C. "Nitric oxide and macrophage antiviral extrinsic activity" . Immunology 98, no. 3 (1999) : 363-370.
http://dx.doi.org/10.1046/j.1365-2567.1999.00864.x
---------- MLA ----------
Benencia, F., Courreges, M.C. "Nitric oxide and macrophage antiviral extrinsic activity" . Immunology, vol. 98, no. 3, 1999, pp. 363-370.
http://dx.doi.org/10.1046/j.1365-2567.1999.00864.x
---------- VANCOUVER ----------
Benencia, F., Courreges, M.C. Nitric oxide and macrophage antiviral extrinsic activity. Immunology. 1999;98(3):363-370.
http://dx.doi.org/10.1046/j.1365-2567.1999.00864.x