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Abstract:

Autosomal STRs, Y-chromosome markers, and mitochondrial DNA sequences were investigated in six Mbyá-Guaraní villages (Fortín M'Bororé, Yryapu, Tabay, Kaaguy Poty, Jejy, and Yaboti), all of them settled within the province of Misiones, northeastern Argentina. One hundred twenty-one unrelated individuals were analyzed. The study involved typing fifteen autosomal STRs, nine Y-chromosome STRs, and four biallele loci in the nonrecombinant region of the Y chromosome, sequencing the mtDNA of hypervariable regions I and II, and detecting the 9-bp ins/del in region V of mtDNA. All autosomal STRs were in Hardy-Weinberg equilibrium. The four major native American mtDNA haplogroups were represented in the sample. Haplogroups A2 and D1 exhibited the highest frequencies (40.5% and 36.0%, respectively), and haplogroups B2 and C1 appeared to be less frequent (17.5% and 6.0%, respectively). The native American haplogroup Q1a3a was observed in a relevant proportion (88.8%). In addition, a nine-STR Y-chromosome haplotype (DYS19*13, DYS389I*14, DYS389II*31, DYS390*24, DYS391*11, DYS392*14, DYS393*11, DYS385A*14, DYS385B*16) exhibited a frequency of more than 36%. Our results indicate that the analyzed Argentinean Guaraní individuals are genetically more closely related to Guaraní from Brazil [genetic distance (.μ)2 = 0.48] than to other related tribes that are geographically closer. Statistical approaches based on autosomal data do not support the hypothesis of genetic drift previously proposed; however, this apparent discrepancy might be due to the lack of sensitivity of the autosomal markers used here. © 2010 Wayne State University Press.

Registro:

Documento: Artículo
Título:Genetic analysis of six communities of Mbyá-Guaraní inhabiting Northeastern Argentina by means of nuclear and mitochondrial polymorphic markers
Autor:Sala, A.; Argüelles, C.F.; Marino, M.E.; Bobillo, C.; Fenocchio, A.; Corach, D.
Filiación:Servicio de Huellas Digitales Geneticas y Catedra de Genetica y Biologia Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
Laboratorio de Citogenética y Genética Humana, Facultad de Ciencias Exactas,Químicas y Naturales, Universidad Nacional de Misiones, Misiones, Argentina
Laboratorio de Análisis de ADN, Facultad de Ciencias Médicas, Universidad de Cuyo, Mendoza, Argentina
Idioma: Inglés
Palabras clave:Autosomal STRs; Mbyá-Guaraní; mtDNA; Native South Amerindian; Y-chromosome STRs; microsatellite DNA; mitochondrial DNA; American Indian; Argentina; article; cell nucleus; female; genetics; human; male; population genetics; Y chromosome; Argentina; Cell Nucleus; Chromosomes, Human, Y; DNA, Mitochondrial; Female; Genetics, Population; Humans; Indians, North American; Male; Microsatellite Repeats
Año:2010
Volumen:82
Número:4
Página de inicio:433
Página de fin:456
Título revista:Human Biology
Título revista abreviado:Hum. Biol.
ISSN:00187143
CODEN:HUBIA
CAS:DNA, Mitochondrial
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00187143_v82_n4_p433_Sala

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Citas:

---------- APA ----------
Sala, A., Argüelles, C.F., Marino, M.E., Bobillo, C., Fenocchio, A. & Corach, D. (2010) . Genetic analysis of six communities of Mbyá-Guaraní inhabiting Northeastern Argentina by means of nuclear and mitochondrial polymorphic markers. Human Biology, 82(4), 433-456.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00187143_v82_n4_p433_Sala [ ]
---------- CHICAGO ----------
Sala, A., Argüelles, C.F., Marino, M.E., Bobillo, C., Fenocchio, A., Corach, D. "Genetic analysis of six communities of Mbyá-Guaraní inhabiting Northeastern Argentina by means of nuclear and mitochondrial polymorphic markers" . Human Biology 82, no. 4 (2010) : 433-456.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00187143_v82_n4_p433_Sala [ ]
---------- MLA ----------
Sala, A., Argüelles, C.F., Marino, M.E., Bobillo, C., Fenocchio, A., Corach, D. "Genetic analysis of six communities of Mbyá-Guaraní inhabiting Northeastern Argentina by means of nuclear and mitochondrial polymorphic markers" . Human Biology, vol. 82, no. 4, 2010, pp. 433-456.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00187143_v82_n4_p433_Sala [ ]
---------- VANCOUVER ----------
Sala, A., Argüelles, C.F., Marino, M.E., Bobillo, C., Fenocchio, A., Corach, D. Genetic analysis of six communities of Mbyá-Guaraní inhabiting Northeastern Argentina by means of nuclear and mitochondrial polymorphic markers. Hum. Biol. 2010;82(4):433-456.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00187143_v82_n4_p433_Sala [ ]