Cellular receptors to glucocorticoids and the effect of dexamethasone and corticosterone on 3H-uridine incorporation into the acid-insoluble fraction were studied in thymocytes from adrenalectomized-diabetic rats and adrenalectomized ones. An increase in the dissociation constant of the hormone-receptor plot was observed when adrenalectomized-diabetic animals were compared to adrenalectomized controls. Meanwhile decreasing concentrations of dexamethasone and corticosterone below receptors saturation, were less active as inhibitor of 3H-uridine incorporation into RNA by thymocytes from adrenalectomized-diabetic than from adrenalectomized ones.
| Documento: | Artículo |
| Título: | Modulation of glucocorticoid effect in thymus of adrenalectomized-diabetic rat |
| Autor: | Roldan, A.; Castillo, M.B. |
| Filiación: | Instituto de Biologia y Medicina Experimental, 1428 Buenos Aires, Argentina |
| Palabras clave: | corticosterone; dexamethasone; dexamethasone h 3; estradiol; glucocorticoid; progesterone; streptozocin; testosterone; unclassified drug; uridine h 3; adrenalectomy; animal model; article; diabetes mellitus; drug efficacy; endocrine system; nonhuman; rat; thymus; Animalia |
| Año: | 1984 |
| Volumen: | 16 |
| Número: | 1 |
| Página de inicio: | 17 |
| Página de fin: | 21 |
| DOI: | http://dx.doi.org/10.1055/s-2007-1014684 |
| Título revista: | Hormone and Metabolic Research |
| Título revista abreviado: | HORM. METAB. RES. |
| ISSN: | 00185043 |
| CODEN: | HMMRA |
| CAS: | corticosterone, 50-22-6; dexamethasone, 50-02-2; estradiol, 50-28-2; progesterone, 57-83-0; streptozocin, 18883-66-4; testosterone, 58-22-0 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00185043_v16_n1_p17_Roldan |
