Abstract:
Several compounds, structurally related to the insect‐growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T. cruzi making them promising good candidates either for blood‐bank sterilization of Chagas'‐disease surveillance, while compounds 11, 12, 13, and 19 showed a moderate degree of activity. Copyright © 1995 Verlag GmbH & Co. KGaA, Weinheim
Registro:
Documento: |
Artículo
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Título: | Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb |
Autor: | Schvartzapel, A.J.; Fichera, L.; Esteva, M.; Rodriguez, J.B.; Gros, E.G. |
Filiación: | Departamento de Quimica Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Buenos Aires, Argentina Instituto Nacional de Investigación de la Enfermedad de Chagas ), Paseo Colón 568, 1063 Buenos Aires, Colón, Buenos Aires, Argentina
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Palabras clave: | carbamic acid derivative; fenoxycarb; insecticide; article; drug activity; drug design; drug synthesis; nonhuman; nuclear magnetic resonance; reaction analysis; trypanosoma cruzi |
Año: | 1995
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Volumen: | 78
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Número: | 5
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Página de inicio: | 1207
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Página de fin: | 1214
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DOI: |
http://dx.doi.org/10.1002/hlca.19950780513 |
Título revista: | Helvetica Chimica Acta
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Título revista abreviado: | Helv. Chim. Acta
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ISSN: | 0018019X
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0018019X_v78_n5_p1207_Schvartzapel |
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Citas:
---------- APA ----------
Schvartzapel, A.J., Fichera, L., Esteva, M., Rodriguez, J.B. & Gros, E.G.
(1995)
. Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb. Helvetica Chimica Acta, 78(5), 1207-1214.
http://dx.doi.org/10.1002/hlca.19950780513---------- CHICAGO ----------
Schvartzapel, A.J., Fichera, L., Esteva, M., Rodriguez, J.B., Gros, E.G.
"Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb"
. Helvetica Chimica Acta 78, no. 5
(1995) : 1207-1214.
http://dx.doi.org/10.1002/hlca.19950780513---------- MLA ----------
Schvartzapel, A.J., Fichera, L., Esteva, M., Rodriguez, J.B., Gros, E.G.
"Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb"
. Helvetica Chimica Acta, vol. 78, no. 5, 1995, pp. 1207-1214.
http://dx.doi.org/10.1002/hlca.19950780513---------- VANCOUVER ----------
Schvartzapel, A.J., Fichera, L., Esteva, M., Rodriguez, J.B., Gros, E.G. Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb. Helv. Chim. Acta. 1995;78(5):1207-1214.
http://dx.doi.org/10.1002/hlca.19950780513