Abstract:
The syntheses of 24‐methylidene[24‐14C]cholesterol (7a) and of 24‐methylidene[7‐3H]cholesterol (7b) from commercially available (20S)‐3‐oxopregn‐4‐ene‐20‐carbaldehyde (1) are described. The method also provides simple preparations of 3β‐acetoxy[24‐14C]chol‐5‐en‐24‐oic acid (4) and 24‐oxocholest‐5‐en‐3β‐yl acetate (6b). Copyright © 1990 Verlag GmbH & Co. KGaA, Weinheim
Registro:
Documento: |
Artículo
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Título: | Synthesis of 24‐Methylidene[24‐14C]‐ and 24‐Methylidene[7‐3H]cholesterol |
Autor: | Monteagudo, E.S.; Burton, G.; Gros, E.G. |
Filiación: | Departamanto de Química Orgánica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, 1428, Argentina
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Año: | 1990
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Volumen: | 73
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Número: | 8
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Página de inicio: | 2097
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Página de fin: | 2100
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DOI: |
http://dx.doi.org/10.1002/hlca.19900730805 |
Título revista: | Helvetica Chimica Acta
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Título revista abreviado: | Helv. Chim. Acta
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ISSN: | 0018019X
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0018019X_v73_n8_p2097_Monteagudo |
Referencias:
- Veleiro, A.S., Burton, G., Gros, E.G., (1985) Phytochemistry, 24, p. 2263
- Monteagudo, E.S., Veleiro, A.S., Burton, G., Gros, E.G., Biosynthesis of Withanolides in Acnistus breviflorus Chemical Degradation of 14C-Labelled Jaborosalactone A and Withaferin A (1987) Zeitschrift für Naturforschung B, 42, p. 1471
- Idler, D.R., Fagerlund, U.H.M., (1957) J. Am. Chem. Soc., 79, p. 1988
- Bottin, J., Fetizon, M., Synthèse du méthylène-24 cholestérol 28−14C (1971) Journal of Labelled Compounds, 7, p. 305
- Burton, G., Gros, E.G., (1976) J. Lab. Compds. Radiopharm., 13, p. 627
- Byon, C.Y., Gut, M., Lai, C.K., (1983) J. Lab. Compds. Radiopharm., 21, p. 65
- Riegel, B., Kaye, I.A., (1944) J. Am. Chem. Soc., 66, p. 723
- Nishikawa, O., Ishimaru, K., Tsuruta, H., Teijin Ltd., Jpn. Patent 79 36, 249; (1979) CA, 91, p. 141103b
- Lombardo, L., (1987) Org. Synth., 65, p. 81
- Sunggak, K., Yong, J.K., Kyo, H.A., (1983) Tetrahedron Lett., 24, p. 3369
- Tökés, L., Throop, L.J., (1972) Organic Reactions in Steroid Chemistry, 1, pp. 199-203. , J. Fried, J. A. Edwards, van Nostrand Reinhoid Co., New York
- Borch, R.F., Bernstein, M.D., Durst, H.D., (1971) J. Am. Chem. Soc., 93, p. 2897
- Isler, O., Gutmann, H., Montavon, M., Rügg, R., Ryser, G., Zeller, P., Synthesen in der Carotinoid-Reihe. 10. Mitteilung. Anwendung derWittig-Reaktion zur Synthese von Estern des Bixins und Crocetins (1957) Helvetica Chimica Acta, 40, p. 1242
- Bergmann, E.D., Solomonovici, A., (1976) Steroids, 27, p. 431
Citas:
---------- APA ----------
Monteagudo, E.S., Burton, G. & Gros, E.G.
(1990)
. Synthesis of 24‐Methylidene[24‐14C]‐ and 24‐Methylidene[7‐3H]cholesterol. Helvetica Chimica Acta, 73(8), 2097-2100.
http://dx.doi.org/10.1002/hlca.19900730805---------- CHICAGO ----------
Monteagudo, E.S., Burton, G., Gros, E.G.
"Synthesis of 24‐Methylidene[24‐14C]‐ and 24‐Methylidene[7‐3H]cholesterol"
. Helvetica Chimica Acta 73, no. 8
(1990) : 2097-2100.
http://dx.doi.org/10.1002/hlca.19900730805---------- MLA ----------
Monteagudo, E.S., Burton, G., Gros, E.G.
"Synthesis of 24‐Methylidene[24‐14C]‐ and 24‐Methylidene[7‐3H]cholesterol"
. Helvetica Chimica Acta, vol. 73, no. 8, 1990, pp. 2097-2100.
http://dx.doi.org/10.1002/hlca.19900730805---------- VANCOUVER ----------
Monteagudo, E.S., Burton, G., Gros, E.G. Synthesis of 24‐Methylidene[24‐14C]‐ and 24‐Methylidene[7‐3H]cholesterol. Helv. Chim. Acta. 1990;73(8):2097-2100.
http://dx.doi.org/10.1002/hlca.19900730805