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Abstract:

In the present report, we studied nucleotide variation in three gene regions of Drosophila melanogaster, spanning >5 kb and showing different degrees of association with the cosmopolitan inversion In(3L)Payne. The analysis of sequence variation in the regions surrounding the breakpoints and the heat shock 83 (Hsp83) gene locus, located close to the distal breakpoint, revealed the absence of shared polymorphisms and the presence of a number of fixed differences between arrangements, indicating absence of genetic exchange. In contrast, for the esterase-6 gene region, located in the center of the inversion, we observed the presence of shared polymorphisms between arrangements suggesting genetic exchange. In the regions close to the breakpoints, the common St arrangement is 10 times more polymorphic than inverted chromosomes. We propose that the lack of recombination between arrangements in these regions coupled with genetic hitchhiking is the best explanation for the low heterozygosity observed in inverted lines. Using the data for the breakpoints, we estimate that this inversion polymorphism is around 0.36 million yr old. Although it is widely accepted that inversions are examples of balanced polymorphisms, none of the current neutrality tests including our Monte Carlo simulations showed significant departure from neutral expectations.

Registro:

Documento: Artículo
Título:Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster
Autor:Hasson, E.; Eanes, W.F.
Filiación:Department of Ecology and Evolution, State University of New York, Stony Brook, NY 11794, United States
GIBE, Depto. de Ciencias Biológicas, Universidad de Buenos Aires, (1428), Buenos Aires, Argentina
Palabras clave:esterase; heat shock protein; article; chromosome breakage; chromosome inversion; drosophila melanogaster; gene rearrangement; genetic variability; nonhuman; priority journal; Animals; Carboxylesterase; Carboxylic Ester Hydrolases; Drosophila melanogaster; Drosophila Proteins; Genes, Insect; Heat-Shock Proteins; Inversion, Chromosome; Polymorphism, Genetic; Protozoan Proteins; Recombination, Genetic; Drosophila melanogaster; Melanogaster
Año:1996
Volumen:144
Número:4
Página de inicio:1565
Página de fin:1575
Título revista:Genetics
Título revista abreviado:GENETICS
ISSN:00166731
CODEN:GENTA
CAS:Carboxylesterase, EC 3.1.1.1; Carboxylic Ester Hydrolases, EC 3.1.1.-; Drosophila Proteins; Heat-Shock Proteins; Hsp83 protein, Drosophila; Protozoan Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166731_v144_n4_p1565_Hasson

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Citas:

---------- APA ----------
Hasson, E. & Eanes, W.F. (1996) . Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster. Genetics, 144(4), 1565-1575.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166731_v144_n4_p1565_Hasson [ ]
---------- CHICAGO ----------
Hasson, E., Eanes, W.F. "Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster" . Genetics 144, no. 4 (1996) : 1565-1575.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166731_v144_n4_p1565_Hasson [ ]
---------- MLA ----------
Hasson, E., Eanes, W.F. "Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster" . Genetics, vol. 144, no. 4, 1996, pp. 1565-1575.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166731_v144_n4_p1565_Hasson [ ]
---------- VANCOUVER ----------
Hasson, E., Eanes, W.F. Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster. GENETICS. 1996;144(4):1565-1575.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166731_v144_n4_p1565_Hasson [ ]