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Abstract:

Reared animals for edible or ornamental purposes are frequently exposed to high aggression and stressful situations. These factors generally arise from conspecifics in densely breeding conditions. In vertebrates, serotonin (5-HT) has been postulated as a key neuromodulator and neurotransmitter involved in aggression and stress. The essential amino acid l-tryptophan (trp) is crucial for the synthesis of 5-HT, and so, leaves a gateway for indirectly augmenting brain 5-HT levels by means of a trp-enriched diet. The cichlid fish Cichlasoma dimerus, locally known as chanchita, is an autochthonous, potentially ornamental species and a fruitful laboratory model which behavior and reproduction has been studied over the last 15 years. It presents complex social hierarchies, and great asymmetries between subordinate and dominant animals in respect to aggression, stress, and reproductive chance. The first aim of this work was to perform a morphological description of chanchita's brain serotonergic system, in both males and females. Then, we evaluated the effects of a trp-supplemented diet, given during 4 weeks, on brain serotonergic activity, stress and sexual steroid hormones, and growth in isolated specimens. Results showed that chanchita's brain serotonergic system is composed of several populations of neurons located in three main areas: pretectum, hypothalamus and raphe, with no clear differences between males and females at a morphological level. Animals fed with trp-enriched diets exhibited higher forebrain serotonergic activity and a significant reduction in their relative cortisol levels, with no effects on sexual steroid plasma levels or growth parameters. Thus, this study points to food trp enrichment as a "neurodietary'' method for elevating brain serotonergic activity and decreasing stress, without affecting growth or sex steroid hormone levels. © 2015 Elsevier Inc.

Registro:

Documento: Artículo
Título:Serotonergic outcome, stress and sexual steroid hormones, and growth in a South American cichlid fish fed with an l-tryptophan enriched diet
Autor:Morandini, L.; Ramallo, M.R.; Moreira, R.G.; Höcht, C.; Somoza, G.M.; Silva, A.; Pandolfi, M.
Filiación:Laboratorio de Neuroendocrinología y Comportamiento, DBBE e IBBEA-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Intendente Güirlades 2160, Ciudad Autónoma de Buenos Aires, C1428EHA, Argentina
Departamento de Fisiologia, Instituto de Biociências-USP, Rua do Matao, travessa 14, sala 220 CidadeUniversitaria, São Paulo, Brazil
Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, Buenos Aires, C1113AAD, Argentina
IIB-INTECH (CONICET-UNSAM), Av. Intendente Marino km 8.2 (B 7130IWA) Chascomús, Buenos Aires, Argentina
Unidad Bases Neurales de la Conducta, Instituto de Investigaciones Biológicas Clemente Estable, Ministerio de Educación y Cultura, Avda. Italia 3318, Montevideo, 11600, Uruguay
Laboratorio de Neurociencias, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo, 11400, Uruguay
Palabras clave:Cichlids; L-Tryptophan; Serotonin; Steroid hormones; Stress; hydrocortisone; sex hormone; tryptophan; hydrocortisone; serotonin; sex hormone; tryptophan; adult; animal cell; animal experiment; animal tissue; Article; brain nerve cell; Cichlasoma dimerus; cichlid; controlled study; diet supplementation; female; growth; hypothalamus; male; nonhuman; pretectum; priority journal; raphe nucleus; serotoninergic system; stress; aggression; animal; blood; brain; diet; drug effects; enzyme immunoassay; metabolism; physiology; sexual behavior; social dominance; Aggression; Animals; Brain; Cichlids; Diet; Female; Gonadal Steroid Hormones; Hierarchy, Social; Hydrocortisone; Immunoenzyme Techniques; Male; Serotonin; Sexual Behavior; Tryptophan
Año:2015
Volumen:223
Página de inicio:27
Página de fin:37
DOI: http://dx.doi.org/10.1016/j.ygcen.2015.10.005
Título revista:General and Comparative Endocrinology
Título revista abreviado:Gen. Comp. Endocrinol.
ISSN:00166480
CODEN:GCENA
CAS:hydrocortisone, 50-23-7; tryptophan, 6912-86-3, 73-22-3; serotonin, 50-67-9; Gonadal Steroid Hormones; Hydrocortisone; Serotonin; Tryptophan
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166480_v223_n_p27_Morandini

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Citas:

---------- APA ----------
Morandini, L., Ramallo, M.R., Moreira, R.G., Höcht, C., Somoza, G.M., Silva, A. & Pandolfi, M. (2015) . Serotonergic outcome, stress and sexual steroid hormones, and growth in a South American cichlid fish fed with an l-tryptophan enriched diet. General and Comparative Endocrinology, 223, 27-37.
http://dx.doi.org/10.1016/j.ygcen.2015.10.005
---------- CHICAGO ----------
Morandini, L., Ramallo, M.R., Moreira, R.G., Höcht, C., Somoza, G.M., Silva, A., et al. "Serotonergic outcome, stress and sexual steroid hormones, and growth in a South American cichlid fish fed with an l-tryptophan enriched diet" . General and Comparative Endocrinology 223 (2015) : 27-37.
http://dx.doi.org/10.1016/j.ygcen.2015.10.005
---------- MLA ----------
Morandini, L., Ramallo, M.R., Moreira, R.G., Höcht, C., Somoza, G.M., Silva, A., et al. "Serotonergic outcome, stress and sexual steroid hormones, and growth in a South American cichlid fish fed with an l-tryptophan enriched diet" . General and Comparative Endocrinology, vol. 223, 2015, pp. 27-37.
http://dx.doi.org/10.1016/j.ygcen.2015.10.005
---------- VANCOUVER ----------
Morandini, L., Ramallo, M.R., Moreira, R.G., Höcht, C., Somoza, G.M., Silva, A., et al. Serotonergic outcome, stress and sexual steroid hormones, and growth in a South American cichlid fish fed with an l-tryptophan enriched diet. Gen. Comp. Endocrinol. 2015;223:27-37.
http://dx.doi.org/10.1016/j.ygcen.2015.10.005