Artículo

Canosa, L.F.; Pozzi, A.G.; Somoza, G.M.; Ceballos, N.R. "Effects of mGnRH on testicular steroidogenesis in the toad Bufo arenarum" (2002) General and Comparative Endocrinology. 127(2):174-180
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Abstract:

GnRH controls vertebrate reproduction in several ways. This hormone not only affects the secretion of gonadotropins from the pituitary gland but also has a direct influence on several gonadal functions such as steroidogenesis, spermatogenesis, and spermiation. In the present paper we have studied the in vitro effects of GnRH on the testicular steroidogenesis of Bufo arenarum to ascertain the role of this peptide in the control of the steroidogenic pathway previously described in this species. It was found that GnRH is able to reduce basal as well as hCG-stimulated testosterone release, having an inhibitory effect on P450c17 activity. Thus, GnRH could be involved in the mechanism that regulates the metabolic change in the testicular steroidogenesis. Additionally, testicular GnRH binding site has been characterised, showing a Kd of 34 nM and a maximum binding of 4.7 pmol/mg protein. © 2002 Elsevier Science (USA). All rights reserved.

Registro:

Documento: Artículo
Título:Effects of mGnRH on testicular steroidogenesis in the toad Bufo arenarum
Autor:Canosa, L.F.; Pozzi, A.G.; Somoza, G.M.; Ceballos, N.R.
Filiación:Laboratorio De Endocrinología Comparada, Departamento De Ciencias Biológicas, Universidad De Buenos Aires, C1428EHA Buenos Aires, Argentina
Instituto Tecnológico De Chascomús, IIB/INTECH (CONICET-Universidad De San Martín), Provincia de Buenos Aires, Argentina
Palabras clave:Amphibian-testis; GnRH-receptor; Gonadotropin-releasing hormone; Steroidogenesis; Steroidogenic-enzyme; Toad; chorionic gonadotropin; cytochrome P450; gonadorelin; gonadotropin; protein; animal tissue; article; binding site; controlled study; enzyme activity; hormone action; hormone binding; hormone release; in vitro study; male; nonhuman; priority journal; protein binding; regulatory mechanism; steroidogenesis; testis; testosterone release; toad
Año:2002
Volumen:127
Número:2
Página de inicio:174
Página de fin:180
DOI: http://dx.doi.org/10.1016/S0016-6480(02)00044-8
Título revista:General and Comparative Endocrinology
Título revista abreviado:Gen. Comp. Endocrinol.
ISSN:00166480
CODEN:GCENA
CAS:chorionic gonadotropin, 9002-61-3; cytochrome P450, 9035-51-2; gonadorelin, 33515-09-2, 9034-40-6; gonadotropin, 63231-54-9; protein, 67254-75-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166480_v127_n2_p174_Canosa

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Citas:

---------- APA ----------
Canosa, L.F., Pozzi, A.G., Somoza, G.M. & Ceballos, N.R. (2002) . Effects of mGnRH on testicular steroidogenesis in the toad Bufo arenarum. General and Comparative Endocrinology, 127(2), 174-180.
http://dx.doi.org/10.1016/S0016-6480(02)00044-8
---------- CHICAGO ----------
Canosa, L.F., Pozzi, A.G., Somoza, G.M., Ceballos, N.R. "Effects of mGnRH on testicular steroidogenesis in the toad Bufo arenarum" . General and Comparative Endocrinology 127, no. 2 (2002) : 174-180.
http://dx.doi.org/10.1016/S0016-6480(02)00044-8
---------- MLA ----------
Canosa, L.F., Pozzi, A.G., Somoza, G.M., Ceballos, N.R. "Effects of mGnRH on testicular steroidogenesis in the toad Bufo arenarum" . General and Comparative Endocrinology, vol. 127, no. 2, 2002, pp. 174-180.
http://dx.doi.org/10.1016/S0016-6480(02)00044-8
---------- VANCOUVER ----------
Canosa, L.F., Pozzi, A.G., Somoza, G.M., Ceballos, N.R. Effects of mGnRH on testicular steroidogenesis in the toad Bufo arenarum. Gen. Comp. Endocrinol. 2002;127(2):174-180.
http://dx.doi.org/10.1016/S0016-6480(02)00044-8