Abstract:
Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect. © 2011 by American Society for Reproductive Medicine.
Registro:
Documento: |
Artículo
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Título: | Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice |
Autor: | Elia, E.M.; Pustovrh, C.; Amalfi, S.; Devoto, L.; Motta, A.B. |
Filiación: | CEFYBO, CONICET, Paraguay 2155, Buenos Aires, Argentina Instituto de Fisiología Biología Molecular y Neurociencia (IFIBYNE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Instituto de Investigaciones Materno Infantil, Hospital Clínico San Borja-Arriarán, Universidad de Chile, Santiago, Chile
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Palabras clave: | Lipoxygenases; metformin; peroxisome proliferator activated receptor gamma; polycystic ovary syndrome; uterus; arachidonate 12 lipoxygenase; metformin; peroxisome proliferator activated receptor gamma; animal experiment; animal model; animal tissue; article; controlled study; enzyme synthesis; female; gene expression; hyperandrogenism; mouse; nonhuman; prepuberty; priority journal; protein expression; rat; signal transduction; uterus |
Año: | 2011
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Volumen: | 95
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Número: | 8
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Página de inicio: | 2534
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Página de fin: | 2537.e1
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DOI: |
http://dx.doi.org/10.1016/j.fertnstert.2011.02.004 |
Título revista: | Fertility and Sterility
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Título revista abreviado: | Fertil. Steril.
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ISSN: | 00150282
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CODEN: | FESTA
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CAS: | arachidonate 12 lipoxygenase, 82391-43-3; metformin, 1115-70-4, 657-24-9
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v95_n8_p2534_Elia |
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Citas:
---------- APA ----------
Elia, E.M., Pustovrh, C., Amalfi, S., Devoto, L. & Motta, A.B.
(2011)
. Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice. Fertility and Sterility, 95(8), 2534-2537.e1.
http://dx.doi.org/10.1016/j.fertnstert.2011.02.004---------- CHICAGO ----------
Elia, E.M., Pustovrh, C., Amalfi, S., Devoto, L., Motta, A.B.
"Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice"
. Fertility and Sterility 95, no. 8
(2011) : 2534-2537.e1.
http://dx.doi.org/10.1016/j.fertnstert.2011.02.004---------- MLA ----------
Elia, E.M., Pustovrh, C., Amalfi, S., Devoto, L., Motta, A.B.
"Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice"
. Fertility and Sterility, vol. 95, no. 8, 2011, pp. 2534-2537.e1.
http://dx.doi.org/10.1016/j.fertnstert.2011.02.004---------- VANCOUVER ----------
Elia, E.M., Pustovrh, C., Amalfi, S., Devoto, L., Motta, A.B. Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice. Fertil. Steril. 2011;95(8):2534-2537.e1.
http://dx.doi.org/10.1016/j.fertnstert.2011.02.004