Abstract:
The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA synthesis on basal conditions. Leuprolide acetate produced an increase in the percentage of apoptotic cells, and when these two factors were co-incubated, ANT blocked the apoptotic effect produced by LA. ©2006 by American Society for Reproductive Medicine.
Registro:
Documento: |
Artículo
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Título: | Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells |
Autor: | Vitale, A.M.; Abramovich, D.; Peluffo, M.C.; Meresman, G.; Tesone, M. |
Filiación: | Instituto de Biología Y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científas Y Técnicas (CONICET), Facultad de Ciencias Exactas Y Naturales, Buenos Aires, Argentina Instituto de Biología Y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
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Palabras clave: | iturelix; leuprorelin; apoptosis; article; cell proliferation; DNA synthesis; drug antagonism; drug effect; granulosa cell; human; human cell; priority journal; Apoptosis; Cell Proliferation; Female; Gonadotropin-Releasing Hormone; Granulosa Cells; Humans; Leuprolide; Oligopeptides |
Año: | 2006
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Volumen: | 85
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Número: | 4
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Página de inicio: | 1064
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Página de fin: | 1067
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DOI: |
http://dx.doi.org/10.1016/j.fertnstert.2005.09.061 |
Título revista: | Fertility and Sterility
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Título revista abreviado: | Fertil. Steril.
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ISSN: | 00150282
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CODEN: | FESTA
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CAS: | iturelix, 112568-12-4; leuprorelin, 53714-56-0, 74381-53-6; Gonadotropin-Releasing Hormone, 33515-09-2; iturelix, 112568-12-4; Leuprolide, 53714-56-0; Oligopeptides
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v85_n4_p1064_Vitale |
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Citas:
---------- APA ----------
Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G. & Tesone, M.
(2006)
. Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells. Fertility and Sterility, 85(4), 1064-1067.
http://dx.doi.org/10.1016/j.fertnstert.2005.09.061---------- CHICAGO ----------
Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G., Tesone, M.
"Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells"
. Fertility and Sterility 85, no. 4
(2006) : 1064-1067.
http://dx.doi.org/10.1016/j.fertnstert.2005.09.061---------- MLA ----------
Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G., Tesone, M.
"Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells"
. Fertility and Sterility, vol. 85, no. 4, 2006, pp. 1064-1067.
http://dx.doi.org/10.1016/j.fertnstert.2005.09.061---------- VANCOUVER ----------
Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G., Tesone, M. Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells. Fertil. Steril. 2006;85(4):1064-1067.
http://dx.doi.org/10.1016/j.fertnstert.2005.09.061