Artículo

La versión final de este artículo es de uso interno de la institución.
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA synthesis on basal conditions. Leuprolide acetate produced an increase in the percentage of apoptotic cells, and when these two factors were co-incubated, ANT blocked the apoptotic effect produced by LA. ©2006 by American Society for Reproductive Medicine.

Registro:

Documento: Artículo
Título:Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
Autor:Vitale, A.M.; Abramovich, D.; Peluffo, M.C.; Meresman, G.; Tesone, M.
Filiación:Instituto de Biología Y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científas Y Técnicas (CONICET), Facultad de Ciencias Exactas Y Naturales, Buenos Aires, Argentina
Instituto de Biología Y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:iturelix; leuprorelin; apoptosis; article; cell proliferation; DNA synthesis; drug antagonism; drug effect; granulosa cell; human; human cell; priority journal; Apoptosis; Cell Proliferation; Female; Gonadotropin-Releasing Hormone; Granulosa Cells; Humans; Leuprolide; Oligopeptides
Año:2006
Volumen:85
Número:4
Página de inicio:1064
Página de fin:1067
DOI: http://dx.doi.org/10.1016/j.fertnstert.2005.09.061
Título revista:Fertility and Sterility
Título revista abreviado:Fertil. Steril.
ISSN:00150282
CODEN:FESTA
CAS:iturelix, 112568-12-4; leuprorelin, 53714-56-0, 74381-53-6; Gonadotropin-Releasing Hormone, 33515-09-2; iturelix, 112568-12-4; Leuprolide, 53714-56-0; Oligopeptides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v85_n4_p1064_Vitale

Referencias:

  • Borm, G., Mannaerts, Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective, safe and convenient: Results of a controlled, randomized, multicentre trial (2000) Hum Reprod, 15, pp. 1490-1498. , The European Orgalutran Study Group B
  • Shapiro, D.B., An overview of GnRH antagonists in infertility treatments. Introduction (2003) Fertil Steril, 80 (1 SUPPL.), pp. 1-S7
  • Andreu, C., Parborell, F., Vanzulli, S., Chemes, H., Tesone, M., Regulation of follicular luteinization by a gonadotropin-releasing hormone agonist: Relationship between steroidogenesis and apoptosis (1998) Mol Reprod Dev, 51, pp. 287-294
  • Stojilkovic, S.S., Reinhart, J., Catt, K.J., Gonadotropin-releasing hormone receptors: Structure and signal transduction pathways (1994) Endocr Rev, 15, pp. 462-499
  • Hsueh, A.J., Jones, P.B., Extrapituitary actions of gonadotropin-releasing hormone (1981) Endocr Rev, 2, pp. 437-461
  • Behrman, H.R., Preston, S.L., Hall, A.K., Cellular mechanism of the antigonadotropic action of luteinizing hormone-releasing hormone in the corpus luteum (1980) Endocrinology, 107, pp. 656-664
  • Peng, C., Fan, N., Ligier, M., Vaananen, J., Leung, P.C., Expression and regulation of gonadotropin-releasing hormone (GnRH) receptor messenger ribonucleic acids in human granulosa-luteal cells (1994) Endocrinology, 135, pp. 1740-1746
  • Clayton, R.N., Harwood, J.P., Catt, K.J., Gonadotropin-releasing hormone analogue binds to luteal cells and inhibits progesterone production (1979) Nature, 282, pp. 90-92
  • Sridaran, R., Philip, G.H., Li, H., Culty, M., Liu, Z., Stocco, D.M., GnRH agonist treatment decreases progesterone synthesis, luteal peripheral benzodiazepine receptor mRNA, ligand binding and steroidogenic acute regulatory protein expression during pregnancy (1999) J Mol Endocrinol, 22, pp. 45-54
  • Hsueh, A.J., Adashi, E.Y., Jones, P.B., Welsh Jr., T.H., Hormonal regulation of the differentiation of cultured ovarian granulosa cells (1984) Endocr Rev, 5, pp. 76-127
  • Kitajima, Y., Endo, T., Manase, K., Nishikawa, A., Shibuya, M., Kudo, R., Gonadotropin-releasing hormone agonist administration reduced vascular endothelial growth factor (VEGF), VEGF receptors, and vascular permeability of the ovaries of hyperstimulated rats (2004) Fertil Steril, 81 (1 SUPPL.), pp. 842-849
  • Parborell, F., Dain, L., Tesone, M., Gonadotropin-releasing hormone agonist affects rat ovarian follicle development by interfering with FSH and growth factors on the prevention of apoptosis (2001) Mol Reprod Dev, 60, pp. 241-247
  • Parborell, F., Pecci, A., Gonzalez, O., Vitale, A., Tesone, M., Effects of a gonadotropin-releasing hormone agonist on rat ovarian follicle apoptosis: Regulation by EGF and the expression of Bcl-2-related genes (2002) Biol Reprod, 67, pp. 481-486
  • Irusta, G., Parborell, F., Peluffo, M., Manna, P.R., Gonzalez-Calvar, S.I., Calandra, R., Steroidogenic acute regulatory protein in ovarian follicles of gonadotropin-stimulated rats is regulated by a gonadotropin-releasing hormone agonist (2003) Biol Reprod, 68, pp. 1577-1583
  • Guerrero, H.E., Stein, P., Asch, R.H., De Fried, E.P., Tesone, M., Effect of a gonadotropin-releasing hormone agonist on luteinizing hormone receptors and steroidogenesis in ovarian cells (1993) Fertil Steril, 59, pp. 803-808
  • Dain, L.B., Bley, M.A., Baranao, J.L., Tesone, M., Evidence for the production of a growth-inhibitory factor by human granulosa-luteal cells (1993) Mol Reprod Dev, 36, pp. 159-163
  • Tilly, J.L., Billig, H., Kowalski, K.I., Hsueh, A.J., Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism (1992) Mol Endocrinol, 6, pp. 1942-1950
  • Abrams, J.M., White, K., Fessler, L.I., Steller, H., Programmed cell death during Drosophila embryogenesis (1993) Development, 117, pp. 29-43
  • Ortmann, O., Weiss, J.M., Diedrich, K., Embryo implantation and GnRH antagonists: Ovarian actions of GnRH antagonists (2001) Hum Reprod, 16, pp. 608-611
  • Parborell, F., Irusta, G., Vitale, A.M., Gonzalez, O., Pecci, A., Tesone, M., GnRH antagonist antide inhibits apoptosis of preovulatory follicle cells in rat ovary (2005) Biol Reprod, 72, pp. 659-666
  • Chun, S.Y., Eisenhauer, K.M., Minami, S., Billig, H., Perlas, E., Hsueh, J.W., Hormonal regulation of apoptosis in early antral follicles: Follicle-stimulating hormone as a major survival factor (1996) Endocrinology, 137, pp. 1447-1456
  • Tilly, J.L., Cell death and species propagation: Molecular and genetic aspects of apoptosis in the vertebrate female gonad (1998) When Cells Die: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death, pp. 431-452. , R.A. Lockshin Z. Zakeri J.L. Tilly Wiley-Liss New York
  • Birnbaumer, L., Shahabi, N., Rivier, J., Vale, W., Evidence for a physiological role of gonadotropin-releasing hormone (GnRH) or GnRH-like material in the ovary (1985) Endocrinology, 116, pp. 1367-1370
  • Ortmann, O., Diedrich, K., Pituitary and extrapituitary actions of gonadotrophin-releasing hormone and its analogues (1999) Hum Reprod, 14 (1 SUPPL.), pp. 194-206
  • Casper, R.F., Erickson, G.F., Rebar, R.W., Yen, S.S., The effect of luteinizing hormone-releasing factor and its agonist on cultured human granulosa cells (1982) Fertil Steril, 37, pp. 406-409
  • Lanzone, A., Panetta, V., Di Simone, N., Arno, E., Fulghesu, A.M., Caruso, A., Effect of gonadotrophin-releasing hormone and related analogue on human luteal cell function in vitro (1989) Hum Reprod, 4, pp. 906-909
  • Minaretzis, D., Jakubowski, M., Mortola, J.F., Pavlou, S.N., Gonadotropin-releasing hormone receptor gene expression in human ovary and granulosa-lutein cells (1995) J Clin Endocrinol Metab, 80, pp. 430-434
  • Lin, Y., Kahn, J.A., Hillensjo, T., Is there a difference in the function of granulosa-luteal cells in patients undergoing in-vitro fertilization either with gonadotrophin-releasing hormone agonist or gonadotrophin-releasing hormone antagonist? (1999) Hum Reprod, 14, pp. 885-888

Citas:

---------- APA ----------
Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G. & Tesone, M. (2006) . Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells. Fertility and Sterility, 85(4), 1064-1067.
http://dx.doi.org/10.1016/j.fertnstert.2005.09.061
---------- CHICAGO ----------
Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G., Tesone, M. "Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells" . Fertility and Sterility 85, no. 4 (2006) : 1064-1067.
http://dx.doi.org/10.1016/j.fertnstert.2005.09.061
---------- MLA ----------
Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G., Tesone, M. "Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells" . Fertility and Sterility, vol. 85, no. 4, 2006, pp. 1064-1067.
http://dx.doi.org/10.1016/j.fertnstert.2005.09.061
---------- VANCOUVER ----------
Vitale, A.M., Abramovich, D., Peluffo, M.C., Meresman, G., Tesone, M. Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells. Fertil. Steril. 2006;85(4):1064-1067.
http://dx.doi.org/10.1016/j.fertnstert.2005.09.061