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Abstract:

Objective: To evaluate the effects of administering combination oral contraceptives (COCs) to patients with endometriosis on the regulation of cell growth in the eutopic endometrium. Design: Prospective study. Setting: Research institute and clinical fertility center. Patient(s): Thirteen women with untreated endometriosis and 13 controls. Intervention(s): Biopsy specimens of the eutopic endometrium were obtained from all subjects. Apoptosis, cell proliferation, and Bcl-2 and Bax expression were examined at the epithelial and stromal levels in the eutopic endometrium from patients with endometriosis before and after 30 days of daily exposure to COCs and from controls. Main Outcome Measure(s): Apoptotic cells were detected by using the dUTP nick-end labeling assay; Ki-67, Bcl-2, and Bax expressions were assessed by using immunohistochemical techniques. Result(s): After exposure to COCs, apoptosis was significantly increased in the eutopic endometrium compared with before COC administration, both at epithelial and stromal levels. Cell proliferation was significantly lowered by COCs. Conclusion(s): COCs showed a positive effect on patients with endometriosis by down-regulating cell proliferation and enhancing apoptosis in the eutopic endometrium. © 2002 by American Society for Reproductive Medicine.

Registro:

Documento: Artículo
Título:Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis
Autor:Meresman, G.F.; Augé, L.; Baraao, R.I.; Lombardi, E.; Tesone, M.; Sueldo, C.
Filiación:Instituto de Biología y Medicina Experimental (IBYME), Buenos Aires, Argentina
Instituto de Ginecología y Fertilidad (IFER), Buenos Aires, Argentina
Instituto de Bioloǵa y Medicina Experimental, Vuelta de Obligado 2490, Buenos Aires (1428), Argentina
Palabras clave:Apoptosis; Cell proliferation; Endometriosis; Eutopic endometrium; Oral contraceptives; deoxyuridinetriphosphate; Ki 67 antigen; oral contraceptive agent; phosphate; protein Bax; protein bcl 2; unclassified drug; apoptosis; article; cell assay; cell growth; cell proliferation; clinical article; clinical trial; controlled clinical trial; controlled study; down regulation; drug effect; drug exposure; endometriosis; endometrium biopsy; epithelium; female; growth regulation; human; immunohistochemistry; nick end labeling; priority journal; prospective study; protein analysis; protein expression; stroma; Apoptosis; bcl-2-Associated X Protein; Cell Division; Contraceptives, Oral; Endometriosis; Endometrium; Epithelial Cells; Female; Humans; Ki-67 Antigen; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reference Values; Stromal Cells
Año:2002
Volumen:77
Número:6
Página de inicio:1141
Página de fin:1147
DOI: http://dx.doi.org/10.1016/S0015-0282(02)03099-6
Título revista:Fertility and Sterility
Título revista abreviado:Fertil. Steril.
ISSN:00150282
CODEN:FESTA
CAS:BAX protein, human; bcl-2-Associated X Protein; Contraceptives, Oral; Ki-67 Antigen; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v77_n6_p1141_Meresman

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Citas:

---------- APA ----------
Meresman, G.F., Augé, L., Baraao, R.I., Lombardi, E., Tesone, M. & Sueldo, C. (2002) . Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis. Fertility and Sterility, 77(6), 1141-1147.
http://dx.doi.org/10.1016/S0015-0282(02)03099-6
---------- CHICAGO ----------
Meresman, G.F., Augé, L., Baraao, R.I., Lombardi, E., Tesone, M., Sueldo, C. "Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis" . Fertility and Sterility 77, no. 6 (2002) : 1141-1147.
http://dx.doi.org/10.1016/S0015-0282(02)03099-6
---------- MLA ----------
Meresman, G.F., Augé, L., Baraao, R.I., Lombardi, E., Tesone, M., Sueldo, C. "Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis" . Fertility and Sterility, vol. 77, no. 6, 2002, pp. 1141-1147.
http://dx.doi.org/10.1016/S0015-0282(02)03099-6
---------- VANCOUVER ----------
Meresman, G.F., Augé, L., Baraao, R.I., Lombardi, E., Tesone, M., Sueldo, C. Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis. Fertil. Steril. 2002;77(6):1141-1147.
http://dx.doi.org/10.1016/S0015-0282(02)03099-6