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Abstract:

Objective: To analyze sperm performance in a group of patients with male immunologic infertility treated with IVF-ET. Design: Retrospective clinical study. Setting: Patients attending a private IVF clinic. Patient(s): The study group comprised seven men with significant levels of surface-bound antisperm antibodies treated in nine IVF cycles. The control group comprised nine couples with female tubal infertility and no indication of male factor infertility treated on the same cycle. Intervention(s): None. Main Outcome Measure(s): Fertilization rate, early embryonic development, implantation, and clinical pregnancy rate (PR). Result(s): Forty-six (44.2%) of 104 inseminated oocytes were fertilized in the study group compared with 65 (84.4%) of 77 in the control group, which was a significant difference. Surface-bound antisperm antibodies significantly inhibited early embryonic cleavage in the study group (13 [28.3%] of 46 embryos with at least 3 blastomeres) compared with the control group (41 [63.1%] of 65 embryos with at least 3 blastomeres). The percentage of good-quality embryos (grades 1 and 2) was similar in the study and control groups (71.7% and 78.5%, respectively). The percentage of poor-quality embryos (grade 4 and two pronuclei) was higher in the study group compared with the control group (13.9% versus 9.2%, respectively); however, the difference was not significant. The implantation rate and clinical PR were lower in the study group (3% and 11%, respectively) compared with the control group (9.5% and 44%, respectively), but the difference was not statistically significant. Conclusion(s): The fertilization rate and early embryonic cleavage of human embryos was found to be reduced significantly in patients with high levels of surface-bound antisperm antibodies. Moreover, embryonic quality and the PR may be compromised by the presence of significant levels of surface-bound antisperm antibodies.

Registro:

Documento: Artículo
Título:Male immunologic infertility: Sperm performance on in vitro fertilization
Autor:Vazquez-Levin, M.H.; Notrica, J.A.; De Fried, E.P.
Filiación:Inst. de Biologí/Med. Exp., Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Inst. de Biol./Medicina Experimental, Buenos Aires, Argentina
Palabras clave:Antisperm antibodies; Early embryonic development; Human embryos; Immunologic infertility; In vitro fertilization; Pregnancy rate; sperm antibody; adult; article; autoimmunity; controlled study; embryo development; female; female infertility; fertilization; fertilization in vitro; human; major clinical study; male; male infertility; nidation; pregnancy rate; priority journal; retrospective study; treatment outcome; Adult; Autoantibodies; Embryo Implantation; Embryonic and Fetal Development; Female; Fertilization; Fertilization in Vitro; Humans; Infertility, Male; Male; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Retrospective Studies; Spermatozoa
Año:1997
Volumen:68
Número:4
Página de inicio:675
Página de fin:681
DOI: http://dx.doi.org/10.1016/S0015-0282(97)00255-0
Título revista:Fertility and Sterility
Título revista abreviado:FERTIL. STERIL.
ISSN:00150282
CODEN:FESTA
CAS:Autoantibodies
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v68_n4_p675_VazquezLevin

Referencias:

  • Clarke, G.N., Elliott, P.J., Smaila, D., Detection of sperm antibodies in semen using the immunobead test: A survey of 813 consecutive patients (1985) Am J Reprod Immunol Microbiol, 7, pp. 118-123
  • Naz, R.K., Menge, A.C., Antisperm antibodies: Origin, regulation, and sperm reactivity in human infertility (1994) Fertil Steril, 61, pp. 1001-1013
  • Clarke, G.N., Lopata, A., McBain, J.C., Baker, H.W.G., Johnston, W.I.H., Effect of sperm antibodies in males in human in vitro fertilization (1985) Am J Reprod Immunol Microbiol, 8, pp. 62-66
  • Junk, S.M., Matson, P.L., Yovich, J.M., Bootsma, B., Yovich, J.L., The fertilization of human oocytes by spermatozoa from men with antispermatozoal antibodies in semen (1986) J In Vitro Fert Embryo Transf, 3, pp. 350-352
  • De Almeida, M., Gazagne, I., Jeulin, C., Herry, M., Belaisch-Allart, J., Frydman, R., Vitro processing of sperm with autoantibodies and in-vitro fertilization results (1989) Hum Reprod, 4, pp. 49-53
  • Bronson, R.A., Cooper, G.W., Rosenfeld, D.L., Sperm-specific isoantibodies and autoantibodies inhibit the binding of human sperm to human zona pellucida (1982) Fertil Steril, 38, pp. 724-729
  • Zouari, R., De Almeida, M., Effect of sperm associated antibodies on human sperm ability to bind to zona pellucida and to penetrate zona-free hamster oocytes (1993) J Reprod Immunol, 24, pp. 175-186
  • Zouari, R., De Almeida, M., Feneux, D., Effect of sperm-associated antibodies on the dynamics of sperm movement and on the acrosome reaction of human spermatozoa (1992) J Reprod Immunol, 22, pp. 59-72
  • Bronson, R.A., Cooper, G.W., Rosenfeld, D.L., Ability of antibody-bound human sperm to penetrate zona-free hamster ova in vitro (1982) Fertil Steril, 36, pp. 778-783
  • Naz, R.K., Effects of antisperm antibodies on early cleavage of fertilized ova (1992) Biol Reprod, 46, pp. 130-139
  • (1987) Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction. 2nd ed., , Cambridge: The Press Syndicate of the University of Cambridge
  • Kruger, T., Acosta, A., Simmons, K., Swanson, R.J., Matta, J.F., Oehninger, S., Predictive value of abnormal sperm morphology in in vitro fertilization (1988) Fertil Steril, 49, pp. 112-117
  • Veeck, L., (1986) Atlas of the Human Oocyte and Early Conceptus, , Baltimore: Williams & Wilkins
  • Lahteenmaki, A., Vitro fertilization in the presence of antisperm antibodies detected by the mixed antiglobulin reaction (MAR) and the tray agglutination test (1993) Hum Reprod, 8, pp. 84-88
  • Rajah, S.V., Parslow, J.M., Howell, R.J., Hendry, W.F., The effects on in-vitro fertilization of autoantibodies to spermatozoa in subfertile men (1993) Hum Reprod, 8, pp. 1079-1082
  • Zouari, R., De Almeida, M., Rodriguez, D., Jouannet, P., Localization of antibodies on spermatozoa and sperm movement characteristics are good predictors of in vitro fertilization success in cases of male autoimmune infertility (1993) Fertil Steril, 59, pp. 606-612
  • Clarke, G.N., Hyne, R.V., Du Plessis, Y., Johnston, W., Sperm antibodies and human in vitro fertilization (1988) Fertil Steril, 49, pp. 1018-1025
  • Franken, D., Windt, M.L., Oosthuizen, T., Kruger, T., Menkweld, K., Coddington, C., Assisted reproductive technologies may obviate apparent immunologic infertility (1991) Andrologia, 23, pp. 291-295
  • Ahmad, K., Naz, R.K., Effects of human antisperm antibodies on development of preimplantation embryos (1992) Arch Androl, 29, pp. 9-20
  • Mandelbaum, S.L., Diamond, M.P., Decherney, A.H., Relationship of antisperm antibodies to oocyte fertilization in in vitro fertilization-embryo transfer (1987) Fertil Steril, 47, pp. 644-651
  • Vazquez-Levin, M.H., Kaplan, P., Guzman, I., Grunfeld, L., Garrisi, G.J., Navot, D., The effect of female antisperm antibodies on in vitro fertilization, early embryonic development, and pregnancy outcome (1991) Fertil Steril, 56, pp. 84-88
  • O'Rand, M.G., The presence of sperm-specific surface isoantigens in the egg following fertilization (1977) J Exp Zool, 202, pp. 267-273
  • Nagy, Z.P., Verheyen, G., Liu, J., Joris, H., Janssenswillen, C., Wisanto, A., Results of 55 intracytoplasmic sperm injection cycles in the treatment of male-immunological infertility (1995) Hum Reprod, 10, pp. 1775-1780
  • Snow, K., Ball, G.D., Characterization of human sperm antigens and antisperm antibodies in infertile patients (1992) Fertil Steril, 58, pp. 1011-1019
  • Browning, H., Strome, S., A sperm-supplied factor required for embryogenesis in C. elegans (1996) Development, 122, pp. 391-404

Citas:

---------- APA ----------
Vazquez-Levin, M.H., Notrica, J.A. & De Fried, E.P. (1997) . Male immunologic infertility: Sperm performance on in vitro fertilization. Fertility and Sterility, 68(4), 675-681.
http://dx.doi.org/10.1016/S0015-0282(97)00255-0
---------- CHICAGO ----------
Vazquez-Levin, M.H., Notrica, J.A., De Fried, E.P. "Male immunologic infertility: Sperm performance on in vitro fertilization" . Fertility and Sterility 68, no. 4 (1997) : 675-681.
http://dx.doi.org/10.1016/S0015-0282(97)00255-0
---------- MLA ----------
Vazquez-Levin, M.H., Notrica, J.A., De Fried, E.P. "Male immunologic infertility: Sperm performance on in vitro fertilization" . Fertility and Sterility, vol. 68, no. 4, 1997, pp. 675-681.
http://dx.doi.org/10.1016/S0015-0282(97)00255-0
---------- VANCOUVER ----------
Vazquez-Levin, M.H., Notrica, J.A., De Fried, E.P. Male immunologic infertility: Sperm performance on in vitro fertilization. FERTIL. STERIL. 1997;68(4):675-681.
http://dx.doi.org/10.1016/S0015-0282(97)00255-0